iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066565

Ensembl Protein ID

ENSMPUP00000004846.1

UniProt Accession

M3Y0J5; M3Y0J5_MUSPF

Genbank Protein ID

ENSMPUP00000004846

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01017736

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000004886.1	ENSMPUT00000004930.1	ENSMPUP00000004846.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-11	43.9	422	473

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++lydy+++ +de ++   d+++ i  e  degW++g    +g  GlfP+n+v+ l
   Q: 422  IALYDYQGEGSDEISFDPDDIITDI--EMVDEGWWRG--RCHGHFGLFPANYVKLL 473
           79**********************9..9*********..8*************977 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 60
VSEEHDSLKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAAGT CTGTAGTAGG GCATGATGTA TCTGTTTCCG TGGAGACCCA GGGTGATGAC 60
TGGGATACAG ACCCTGACTT TGTGGTGAGT TTGGGAATAG CTTTGCTTGC TTGGAAAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	91.49	0.00e+00	765.00
IUUC-Bta-012591	Bos taurus	86.60	0.00e+00	657.00
IUUC-Cja-019982	Callithrix jacchus	85.18	0.00e+00	661.00
IUUC-Cfa-020262	Canis familiaris	89.75	0.00e+00	714.00
IUUC-Cpo-021362	Cavia porcellus	84.21	0.00e+00	639.00
IUUC-Csa-023911	Chlorocebus sabaeus	87.61	0.00e+00	676.00
IUUC-Dor-030437	Dipodomys ordii	73.22	2.00e-161	561.00
IUUC-Ete-033160	Echinops telfairi	73.29	2.00e-145	508.00
IUUC-Eca-033269	Equus caballus	86.56	0.00e+00	716.00
IUUC-Eeu-035032	Erinaceus europaeus	73.16	3.00e-117	415.00
IUUC-Fca-035999	Felis catus	86.17	0.00e+00	777.00
IUUC-Ggo-044505	Gorilla gorilla	81.20	0.00e+00	658.00
IUUC-Hsa-046728	Homo sapiens	89.55	1.00e-160	559.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	66.91	5.00e-167	580.00
IUUC-Laf-054202	Loxodonta africana	80.94	0.00e+00	664.00
IUUC-Mcc-055824	Macaca mulatta	87.39	0.00e+00	675.00
IUUC-Mmr-061281	Microcebus murinus	74.48	1.00e-158	552.00
IUUC-Mdo-062515	Monodelphis domestica	67.83	3.00e-147	514.00
IUUC-Mmu-064341	Mus musculus	79.59	0.00e+00	655.00
IUUC-Mlu-066942	Myotis lucifugus	81.31	0.00e+00	672.00
IUUC-Nle-069436	Nomascus leucogenys	87.58	0.00e+00	675.00
IUUC-Opr-070288	Ochotona princeps	78.03	4.00e-162	564.00
IUUC-Ocu-074686	Oryctolagus cuniculus	78.89	2.00e-167	582.00
IUUC-Ola-086894	Oryzias latipes	59.44	1.00e-93	337.00
IUUC-Oga-088585	Otolemur garnettii	78.81	0.00e+00	645.00
IUUC-Oar-089686	Ovis aries	85.80	0.00e+00	692.00
IUUC-Ptr-090461	Pan troglodytes	90.40	3.00e-162	565.00
IUUC-Pan-091887	Papio anubis	88.03	0.00e+00	675.00
IUUC-Psi-093785	Pelodiscus sinensis	69.61	9.00e-113	400.00
IUUC-Pab-098222	Pongo abelii	88.03	0.00e+00	676.00
IUUC-Pca-100668	Procavia capensis	82.25	0.00e+00	662.00
IUUC-Pva-102767	Pteropus vampyrus	73.39	3.00e-167	581.00
IUUC-Rno-106001	Rattus norvegicus	81.04	0.00e+00	655.00
IUUC-Spo-108101	Schizosaccharomyces pombe	54.55	5.00e-15	76.60
IUUC-Sar-113338	Sorex araneus	75.49	1.00e-164	572.00
IUUC-Ssc-116027	Sus scrofa	85.60	0.00e+00	702.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence