• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105930
UUCD1 version UUC-RaN-00876
Ensembl Protein ID ENSRNOP00000012984.5
UniProt Accession Q5XIN1; MDM4_RAT
Genbank Protein ID AAH83647.1
Protein Name Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4
Genbank Nucleotide ID BC083647
Gene Name Mdm4; Mdmx
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000009696.6 ENSRNOT00000012984.5 ENSRNOP00000012984.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 83.94 0.00e+00 741.00 IUUC-Hsa-046950
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity).
 Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity).
Protein Sequence
(Fasta)
MTSHSTSAQC SASDSACRIS SEQINQQVRP KLQLLKILQA AGAQGEVFTM KEVMHYLGQY 60
IMVKQLYDQQ EQHLVYCGGD LLGDLLGCQS FSVKDPSPLY DMLRKNLVTS ASVNTDAAQT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105930|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGTGCAGG CCTTAGGACC TTCAACTGCC ACCCCTCCCC CAGCTAGGAG GGGGGAGCGA 60
CTCATGGAGC GGCCGTAAGG TGTGGCGGTG GGGTCTGGTC CGCGGGGTGC GGGGAGGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105930|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015458--MDM4
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2
Pfam

PF02201--SWIB
PF00641--zf-RanBP
Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0071456--P:cellular response to hypoxia
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0045023--P:G0 to G1 transition
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0042177--P:negative regulation of protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006461--P:protein complex assembly
GO:0050821--P:protein stabilization
KEGG rno:304798
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001467 Ailuropoda melanoleuca 83.77 0.00e+00 719.00
IUUC-Apl-003800 Anas platyrhynchos 60.85 3.00e-153 535.00
IUUC-Aca-004608 Anolis carolinensis 57.35 2.00e-136 479.00
IUUC-Ame-010869 Astyanax mexicanus 46.67 7.00e-104 370.00
IUUC-Bta-013287 Bos taurus 81.10 0.00e+00 770.00
IUUC-Cja-019305 Callithrix jacchus 82.52 0.00e+00 736.00
IUUC-Cfa-020393 Canis familiaris 83.16 0.00e+00 736.00
IUUC-Cpo-022166 Cavia porcellus 81.97 0.00e+00 688.00
IUUC-Csa-023654 Chlorocebus sabaeus 83.54 0.00e+00 719.00
IUUC-Cho-024403 Choloepus hoffmanni 81.27 1.00e-113 403.00
IUUC-Dre-027754 Danio rerio 46.84 1.00e-111 396.00
IUUC-Dno-029630 Dasypus novemcinctus 80.53 0.00e+00 745.00
IUUC-Dor-031064 Dipodomys ordii 65.17 1.00e-177 615.00
IUUC-Ete-032901 Echinops telfairi 72.82 0.00e+00 689.00
IUUC-Eca-034234 Equus caballus 84.35 0.00e+00 828.00
IUUC-Eeu-035015 Erinaceus europaeus 75.53 2.00e-80 293.00
IUUC-Fca-036587 Felis catus 83.54 0.00e+00 760.00
IUUC-Fal-036906 Ficedula albicollis 52.75 2.00e-131 462.00
IUUC-Gmo-038646 Gadus morhua 44.94 7.00e-100 357.00
IUUC-Gga-040124 Gallus gallus 58.65 2.00e-113 402.00
IUUC-Gac-042397 Gasterosteus aculeatus 45.90 2.00e-109 389.00
IUUC-Ggo-045505 Gorilla gorilla 83.74 0.00e+00 733.00
IUUC-Hsa-046950 Homo sapiens 83.94 0.00e+00 738.00
IUUC-Itr-048886 Ictidomys tridecemlineatus 81.71 0.00e+00 741.00
IUUC-Lch-050141 Latimeria chalumnae 52.48 2.00e-120 426.00
IUUC-Loc-051921 Lepisosteus oculatus 48.11 4.00e-112 398.00
IUUC-Laf-054281 Loxodonta africana 78.25 0.00e+00 704.00
IUUC-Mcc-055462 Macaca mulatta 80.28 0.00e+00 676.00
IUUC-Meu-056294 Macropus eugenii 70.93 3.00e-145 508.00
IUUC-Mga-059924 Meleagris gallopavo 60.12 2.00e-165 575.00
IUUC-Mmr-061428 Microcebus murinus 83.54 0.00e+00 790.00
IUUC-Mdo-062643 Monodelphis domestica 72.43 0.00e+00 694.00
IUUC-Mmu-063229 Mus musculus 94.90 0.00e+00 909.00
IUUC-Mpu-065782 Mustela putorius furo 82.59 0.00e+00 723.00
IUUC-Mlu-068105 Myotis lucifugus 75.20 0.00e+00 717.00
IUUC-Nle-069549 Nomascus leucogenys 83.94 0.00e+00 736.00
IUUC-Opr-070568 Ochotona princeps 82.37 0.00e+00 707.00
IUUC-Ont-072276 Oreochromis niloticus 47.71 9.00e-120 423.00
IUUC-Oan-072787 Ornithorhynchus anatinus 69.72 0.00e+00 640.00
IUUC-Ocu-074912 Oryctolagus cuniculus 82.93 0.00e+00 749.00
IUUC-Ola-087037 Oryzias latipes 45.34 2.00e-97 349.00
IUUC-Oga-088953 Otolemur garnettii 82.06 0.00e+00 743.00
IUUC-Oar-089202 Ovis aries 81.10 0.00e+00 776.00
IUUC-Ptr-090964 Pan troglodytes 83.74 0.00e+00 735.00
IUUC-Pan-091975 Papio anubis 83.74 0.00e+00 737.00
IUUC-Psi-093558 Pelodiscus sinensis 61.10 6.00e-157 546.00
IUUC-Pfo-096454 Poecilia formosa 48.39 6.00e-114 404.00
IUUC-Pab-098123 Pongo abelii 83.54 0.00e+00 737.00
IUUC-Pca-101112 Procavia capensis 71.95 0.00e+00 655.00
IUUC-Pva-103098 Pteropus vampyrus 75.41 0.00e+00 708.00
IUUC-Sha-107512 Sarcophilus harrisii 71.54 3.00e-179 621.00
IUUC-Sar-113584 Sorex araneus 74.13 0.00e+00 645.00
IUUC-Tgu-116766 Taeniopygia guttata 56.11 3.00e-101 361.00
IUUC-Tru-117829 Takifugu rubripes 47.37 3.00e-114 405.00
IUUC-Tsy-119268 Tarsius syrichta 71.14 3.00e-176 611.00
IUUC-Tni-120204 Tetraodon nigroviridis 47.06 7.00e-109 387.00
IUUC-Tbe-127840 Tupaia belangeri 78.57 3.00e-116 411.00
IUUC-Ttr-128863 Tursiops truncatus 80.89 0.00e+00 744.00
IUUC-Vpa-130718 Vicugna pacos 82.58 0.00e+00 723.00
IUUC-Xtr-132320 Xenopus tropicalis 46.97 2.00e-89 322.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved