iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000005986.15	ENSMUST00000169192.7	ENSMUSP00000130995.1
ENSMUSG00000005986.15	ENSMUST00000056888.12	ENSMUSP00000053783.6
ENSMUSG00000005986.15	ENSMUST00000163858.7	ENSMUSP00000128932.1
ENSMUSG00000005986.15	ENSMUST00000166031.1	ENSMUSP00000130505.1
ENSMUSG00000005986.15	ENSMUST00000170283.1	ENSMUSP00000126349.1
ENSMUSG00000005986.15	ENSMUST00000167215.1	ENSMUSP00000128037.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UIM	92.40	0.00e+00	974.00	IUUC-Hsa-046696

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity).

Protein Sequence
(Fasta)

MAGLGPTFPL HRLVWANRHR ELEAALHSRK HDIEQEDPQG RTPLELAVTL GNLESVRVLL 60
RHNANVGKES HQGWAVLQEA VSTGDPEMVQ LVLQYRDFQR ATQRLAGIPE LLNKLRQAPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCTCCCTG CCGCCTTCGC TCTTGCTGCG GCGGCTTCTA GCAGGGGTCC GCGGGGCTGC 60
AGCGGGTGCG GCTGAGGTGC GGCTCAGAGC GGAGGAGCAG GGGACGTGCC AGGCGCAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR021832--ANKRD13
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR003903--UIM_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50330--UIM

Pfam

PF12796--Ank_2
PF11904--GPCR_chapero_1

SMART

SM00248--ANK
SM00726--UIM

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005770--C:late endosome
GO:0005886--C:plasma membrane

KEGG

mmu:68423

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001892	Ailuropoda melanoleuca	90.96	0.00e+00	927.00
IUUC-Aca-004711	Anolis carolinensis	72.24	0.00e+00	907.00
IUUC-Ame-011241	Astyanax mexicanus	63.55	0.00e+00	733.00
IUUC-Bta-013346	Bos taurus	93.35	0.00e+00	921.00
IUUC-Cja-019755	Callithrix jacchus	93.41	0.00e+00	828.00
IUUC-Cfa-020633	Canis familiaris	91.93	0.00e+00	989.00
IUUC-Cpo-021676	Cavia porcellus	91.91	0.00e+00	1056.00
IUUC-Csa-023215	Chlorocebus sabaeus	94.09	0.00e+00	807.00
IUUC-Dre-027486	Danio rerio	67.83	0.00e+00	815.00
IUUC-Dno-030054	Dasypus novemcinctus	85.26	0.00e+00	745.00
IUUC-Dor-030688	Dipodomys ordii	90.63	0.00e+00	796.00
IUUC-Dme-031648	Drosophila melanogaster	40.22	7.00e-138	484.00
IUUC-Eca-033452	Equus caballus	91.38	0.00e+00	961.00
IUUC-Fca-036526	Felis catus	91.53	0.00e+00	948.00
IUUC-Fal-036633	Ficedula albicollis	80.23	0.00e+00	831.00
IUUC-Gmo-038939	Gadus morhua	72.64	0.00e+00	730.00
IUUC-Gga-041273	Gallus gallus	80.39	0.00e+00	787.00
IUUC-Gac-042062	Gasterosteus aculeatus	68.58	0.00e+00	827.00
IUUC-Ggo-044997	Gorilla gorilla	93.17	0.00e+00	989.00
IUUC-Hsa-046696	Homo sapiens	92.98	0.00e+00	986.00
IUUC-Itr-048122	Ictidomys tridecemlineatus	94.88	0.00e+00	994.00
IUUC-Lch-049628	Latimeria chalumnae	67.18	0.00e+00	779.00
IUUC-Laf-053963	Loxodonta africana	87.55	0.00e+00	961.00
IUUC-Mcc-055559	Macaca mulatta	86.77	0.00e+00	858.00
IUUC-Meu-056015	Macropus eugenii	85.03	0.00e+00	764.00
IUUC-Mga-059736	Meleagris gallopavo	82.38	5.00e-180	623.00
IUUC-Mmr-060813	Microcebus murinus	93.17	0.00e+00	954.00
IUUC-Mpu-065797	Mustela putorius furo	90.93	0.00e+00	871.00
IUUC-Mlu-066928	Myotis lucifugus	90.34	0.00e+00	811.00
IUUC-Nle-069938	Nomascus leucogenys	93.36	0.00e+00	980.00
IUUC-Ont-071644	Oreochromis niloticus	70.78	0.00e+00	827.00
IUUC-Ola-087183	Oryzias latipes	70.93	0.00e+00	825.00
IUUC-Olu-087726	Ostreococcus lucimarinus	22.44	3.00e-14	72.80
IUUC-Oga-087944	Otolemur garnettii	90.36	0.00e+00	1026.00
IUUC-Oar-089889	Ovis aries	79.24	0.00e+00	884.00
IUUC-Ptr-091094	Pan troglodytes	92.98	0.00e+00	986.00
IUUC-Pan-092736	Papio anubis	93.55	0.00e+00	965.00
IUUC-Pma-094712	Petromyzon marinus	63.06	7.00e-119	420.00
IUUC-Pfo-096046	Poecilia formosa	67.25	0.00e+00	822.00
IUUC-Pab-097819	Pongo abelii	93.64	0.00e+00	802.00
IUUC-Pva-103123	Pteropus vampyrus	85.85	0.00e+00	805.00
IUUC-Rno-106043	Rattus norvegicus	98.35	0.00e+00	1038.00
IUUC-Ssc-115326	Sus scrofa	91.57	0.00e+00	981.00
IUUC-Tru-117688	Takifugu rubripes	70.38	0.00e+00	863.00
IUUC-Tni-120596	Tetraodon nigroviridis	70.22	0.00e+00	863.00
IUUC-Ttr-129074	Tursiops truncatus	89.75	0.00e+00	857.00
IUUC-Vpa-130380	Vicugna pacos	45.86	2.00e-105	375.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence