iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000070950.9	ENST00000427329.5	ENSP00000412054.1
ENSG00000070950.9	ENST00000264926.6	ENSP00000264926.2
ENSG00000070950.9	ENST00000415439.5	ENSP00000402049.1
ENSG00000070950.9	ENST00000418463.5	ENSP00000397852.1
ENSG00000070950.9	ENST00000421052.5	ENSP00000399620.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20675655; 21355096; 19635810; 19228710
UBD/ZnF/UBZ	UBZ	10908344; 18363965; 22742833

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.11	14.7	25	63
UBD/ZnF/UBZ	6.10e-07	31.2	201	224

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC+e f    ++ +C H ++  C+ k+       s + +CP+C
   Q: 25   CGICFEYFNIAMIIPQCSHNYCSLCIRKF------LSYKTQCPTC 63
           9*******88555555**********999......777888**** PP

UBD/ZnF/UBZ

   S: 1    llvCPvCqkmvdqtdfeeHlDeCl 24
           ++ CPvC+  ++++++++HlD+Cl
   Q: 201  KVDCPVCGVNIPESHINKHLDSCL 224
           689********************8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.

Protein Sequence
(Fasta)

MDSLAESRWP PGLAVMKTID DLLRCGICFE YFNIAMIIPQ CSHNYCSLCI RKFLSYKTQC 60
PTCCVTVTEP DLKNNRILDE LVKSLNFARN HLLQFALESP AKSPASSSSK NLAVKVYTPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAAAACTTC TGTTCAGAGC AAGGACGGAT AGTCACTGCG ATTAGGGTGG GCGACCCGGA 60
GGGGGGTCAT GAGCCTGGAC CTTGACAGAT CTGGTGAGGT CTGGATTTGG TTTGATTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02037--SAP

SMART

SM00184--RING
SM00513--SAP
SM00734--ZnF_Rad18

Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0042405--C:nuclear inclusion body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0005657--C:replication fork
GO:0035861--C:site of double-strand break
GO:0003684--F:damaged DNA binding
GO:0042802--F:identical protein binding
GO:0031593--F:polyubiquitin binding
GO:0032403--F:protein complex binding
GO:0043142--F:single-stranded DNA-dependent ATPase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000403--F:Y-form DNA binding
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0006281--P:DNA repair
GO:0060548--P:negative regulation of cell death
GO:0051984--P:positive regulation of chromosome segregation
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0009411--P:response to UV

KEGG

hsa:56852

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002086	Ailuropoda melanoleuca	72.46	0.00e+00	702.00
IUUC-Apl-003657	Anas platyrhynchos	59.20	2.00e-104	373.00
IUUC-Aca-005369	Anolis carolinensis	72.54	3.00e-59	220.00
IUUC-Ago-007876	Ashbya gossypii	32.91	1.00e-09	57.80
IUUC-Acl-008246	Aspergillus clavatus	27.97	2.00e-28	119.00
IUUC-Afl-008666	Aspergillus flavus	30.81	6.00e-15	75.50
IUUC-Afu-009052	Aspergillus fumigatus	27.84	1.00e-26	114.00
IUUC-Ani-009488	Aspergillus nidulans	27.15	1.00e-32	134.00
IUUC-Ang-009681	Aspergillus niger	24.24	3.00e-27	116.00
IUUC-Aor-010037	Aspergillus oryzae	27.70	2.00e-26	113.00
IUUC-Ate-010516	Aspergillus terreus	36.90	1.00e-12	66.60
IUUC-Ame-010630	Astyanax mexicanus	43.92	8.00e-76	277.00
IUUC-Bgr-012178	Blumeria graminis	30.29	4.00e-17	82.40
IUUC-Bta-012976	Bos taurus	75.60	2.00e-171	595.00
IUUC-Bci-013680	Botrytis cinerea	30.81	4.00e-16	79.30
IUUC-Cja-019453	Callithrix jacchus	91.20	0.00e+00	825.00
IUUC-Cfa-020856	Canis familiaris	82.54	0.00e+00	712.00
IUUC-Cpo-021950	Cavia porcellus	77.71	0.00e+00	679.00
IUUC-Csa-023997	Chlorocebus sabaeus	94.06	0.00e+00	838.00
IUUC-Cho-024771	Choloepus hoffmanni	80.86	5.00e-93	335.00
IUUC-Cgl-026668	Colletotrichum gloeosporioides	27.53	2.00e-16	80.90
IUUC-Cme-027202	Cyanidioschyzon merolae	32.94	2.00e-12	67.00
IUUC-Dre-028479	Danio rerio	46.13	1.00e-70	259.00
IUUC-Dno-028943	Dasypus novemcinctus	80.68	0.00e+00	684.00
IUUC-Dor-031046	Dipodomys ordii	69.85	7.00e-142	497.00
IUUC-Dse-031235	Dothistroma septosporum	26.73	2.00e-13	70.90
IUUC-Ete-032503	Echinops telfairi	67.95	2.00e-138	485.00
IUUC-Eca-033725	Equus caballus	85.86	0.00e+00	734.00
IUUC-Eeu-034573	Erinaceus europaeus	57.21	1.00e-116	413.00
IUUC-Fca-036495	Felis catus	73.56	0.00e+00	635.00
IUUC-Fal-036791	Ficedula albicollis	50.99	2.00e-93	336.00
IUUC-Fox-037868	Fusarium oxysporum	35.71	2.00e-12	67.00
IUUC-Fso-038144	Fusarium solani	31.55	3.00e-16	79.30
IUUC-Gmo-039152	Gadus morhua	45.40	2.00e-65	243.00
IUUC-Ggr-039737	Gaeumannomyces graminis	28.96	1.00e-14	74.30
IUUC-Gga-040788	Gallus gallus	55.73	2.00e-104	372.00
IUUC-Gac-041993	Gasterosteus aculeatus	43.81	7.00e-77	281.00
IUUC-Ggo-044889	Gorilla gorilla	97.79	0.00e+00	865.00
IUUC-Itr-048998	Ictidomys tridecemlineatus	80.56	0.00e+00	704.00
IUUC-Kpa-049300	Komagataella pastoris	36.00	2.00e-08	53.10
IUUC-Lch-050172	Latimeria chalumnae	53.25	3.00e-70	258.00
IUUC-Loc-052609	Lepisosteus oculatus	50.41	6.00e-85	308.00
IUUC-Laf-053889	Loxodonta africana	72.99	8.00e-159	553.00
IUUC-Mcc-055853	Macaca mulatta	95.77	0.00e+00	841.00
IUUC-Meu-056866	Macropus eugenii	54.09	1.00e-81	296.00
IUUC-Mor-057071	Magnaporthe oryzae	28.45	4.00e-31	129.00
IUUC-Mpo-057628	Magnaporthe poae	27.13	5.00e-14	72.40
IUUC-Mla-058953	Melampsora laricipopulina	24.51	2.00e-17	84.00
IUUC-Mga-059687	Meleagris gallopavo	52.81	8.00e-103	367.00
IUUC-Mvi-060412	Microbotryum violaceum	33.75	6.00e-11	62.40
IUUC-Mmr-061563	Microcebus murinus	84.43	0.00e+00	738.00
IUUC-Mdo-062655	Monodelphis domestica	60.39	5.00e-128	451.00
IUUC-Mmu-063647	Mus musculus	63.86	6.00e-161	560.00
IUUC-Mpu-065778	Mustela putorius furo	82.67	0.00e+00	741.00
IUUC-Mlu-068205	Myotis lucifugus	79.41	0.00e+00	639.00
IUUC-Nfi-068501	Neosartorya fischeri	25.57	1.00e-26	114.00
IUUC-Ncr-068917	Neurospora crassa	27.18	2.00e-17	84.30
IUUC-Nle-068990	Nomascus leucogenys	97.58	0.00e+00	859.00
IUUC-Opr-071146	Ochotona princeps	73.59	5.00e-175	607.00
IUUC-Ont-071835	Oreochromis niloticus	45.88	6.00e-73	268.00
IUUC-Oan-072827	Ornithorhynchus anatinus	40.16	2.00e-44	172.00
IUUC-Ocu-073986	Oryctolagus cuniculus	77.89	0.00e+00	650.00
IUUC-Ola-086997	Oryzias latipes	42.90	4.00e-64	238.00
IUUC-Olu-087771	Ostreococcus lucimarinus	34.12	2.00e-10	60.80
IUUC-Oga-088092	Otolemur garnettii	84.77	0.00e+00	758.00
IUUC-Oar-089651	Ovis aries	81.07	0.00e+00	657.00
IUUC-Ptr-091103	Pan troglodytes	98.59	0.00e+00	872.00
IUUC-Pan-092478	Papio anubis	94.06	0.00e+00	840.00
IUUC-Psi-093356	Pelodiscus sinensis	51.98	3.00e-119	422.00
IUUC-Pfo-096663	Poecilia formosa	42.41	6.00e-61	228.00
IUUC-Pab-098515	Pongo abelii	98.18	0.00e+00	864.00
IUUC-Pca-100588	Procavia capensis	63.40	5.00e-130	457.00
IUUC-Pva-102377	Pteropus vampyrus	84.85	0.00e+00	741.00
IUUC-Pgr-103556	Puccinia graminis	23.75	1.00e-15	78.20
IUUC-Pte-104362	Pyrenophora teres	27.35	2.00e-12	67.40
IUUC-Pyt-104823	Pyrenophora triticirepentis	28.05	7.00e-13	68.60
IUUC-Rno-105866	Rattus norvegicus	76.00	2.00e-174	605.00
IUUC-Sce-106454	Saccharomyces cerevisiae	36.00	7.00e-11	62.00
IUUC-Sha-107515	Sarcophilus harrisii	59.64	3.00e-120	425.00
IUUC-Sja-107689	Schizosaccharomyces japonicus	27.39	1.00e-13	70.90
IUUC-Spo-108248	Schizosaccharomyces pombe	42.50	5.00e-14	72.00
IUUC-Ssl-108430	Sclerotinia sclerotiorum	26.22	5.00e-16	79.30
IUUC-Sre-115123	Sporisorium reilianum	24.56	2.00e-12	67.00
IUUC-Ssc-115992	Sus scrofa	79.80	3.00e-152	531.00
IUUC-Tgu-117286	Taeniopygia guttata	53.63	8.00e-99	353.00
IUUC-Tru-117959	Takifugu rubripes	45.00	1.00e-67	250.00
IUUC-Tsy-119286	Tarsius syrichta	62.50	4.00e-149	521.00
IUUC-Tni-120570	Tetraodon nigroviridis	47.74	2.00e-73	269.00
IUUC-Tre-121893	Trichoderma reesei	26.44	5.00e-14	72.40
IUUC-Tvi-122405	Trichoderma virens	24.25	2.00e-25	110.00
IUUC-Tbe-127758	Tupaia belangeri	78.70	4.00e-84	305.00
IUUC-Ttr-128841	Tursiops truncatus	83.84	0.00e+00	716.00
IUUC-Vda-130021	Verticillium dahliae	28.32	6.00e-17	81.30
IUUC-Vpa-130169	Vicugna pacos	76.11	3.00e-155	541.00
IUUC-Xtr-132308	Xenopus tropicalis	51.47	5.00e-101	360.00
IUUC-Xma-133868	Xiphophorus maculatus	41.44	8.00e-64	237.00
IUUC-Yli-134474	Yarrowia lipolytica	32.52	1.00e-15	77.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence