iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	TRANSFAC	miRNAMap
RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.20e-32	113.5	283	410

Active Site

Position(s)	Description	Evidence
290	N/A	{ECO:0000250}
293	Nucleophile	ECO:0000250}
404		{ECO:0000250}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfdddslsdalveaLreltseylqkesdffsefieekedekefcqklvepeakgeeihifaLaqiLs 90
           ++ ++ +DGnCL+rAvs++   v++d+s    l+++Lre+t +y++++ d+fs++ie+  d+ ef+  ++++ a+++  ++ a+ q+L+
   Q: 283  YRFHIIPDGNCLYRAVSKT---VYGDQS----LHRELREQTVHYIADHLDHFSPLIEG--DVGEFIIAAAQDGAWAGYPELLAMGQMLN 362
           78899**************...******....**************************..9**************************** PP
   S: 91   rpiivvdvdsleskvggillpllfpeeklkkpivLlY.rsgHYdaLva 137
           ++i++++  +les++ ++++++l pe++l+++i+L++ ++gHYda+++
   Q: 363  VNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWlSNGHYDAVFD 410
           *********************************************986 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin.

Protein Sequence
(Fasta)

MQLYSSVCTH YPAGTPGPTA AAPPATAAAA FKVSLQSASP AAAAPEPDTG ERPPAAATEP 60
REAAAAAAMP AFSACFERSG SAAAPPGACS KPPLPPHFTS TAHIAVRALG AERLLLPPPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGCGGGCGG GCGGCGCTCG TCTGAGCGGG CAGCTCCTCC AACCGTCCCC AGCGGCCGGC 60
GCGGGGCACA GCTGCGCCAG CGTCCTACGC CCGAGTCCCC GGCCGAGCGC GCGCCCTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0070536--P:protein K63-linked deubiquitination

KEGG

mmu:71198

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003381	Anas platyrhynchos	86.13	9.00e-91	325.00
IUUC-Aca-004882	Anolis carolinensis	68.88	2.00e-78	285.00
IUUC-Ame-011068	Astyanax mexicanus	75.52	2.00e-90	326.00
IUUC-Bta-013311	Bos taurus	96.12	3.00e-120	425.00
IUUC-Cel-018389	Caenorhabditis elegans	38.75	6.00e-10	60.10
IUUC-Cja-019570	Callithrix jacchus	78.30	1.00e-147	516.00
IUUC-Cfa-021137	Canis familiaris	96.98	2.00e-118	418.00
IUUC-Csa-024211	Chlorocebus sabaeus	70.82	3.00e-146	511.00
IUUC-Dre-028539	Danio rerio	77.60	5.00e-93	334.00
IUUC-Fal-037563	Ficedula albicollis	85.57	2.00e-101	361.00
IUUC-Gmo-039313	Gadus morhua	66.49	5.00e-77	280.00
IUUC-Gga-040877	Gallus gallus	85.05	6.00e-101	360.00
IUUC-Gac-042036	Gasterosteus aculeatus	66.05	1.00e-85	308.00
IUUC-Ggo-045008	Gorilla gorilla	73.27	3.00e-143	501.00
IUUC-Hsa-045990	Homo sapiens	71.84	9.00e-144	503.00
IUUC-Lch-049775	Latimeria chalumnae	78.57	9.00e-97	347.00
IUUC-Loc-052017	Lepisosteus oculatus	76.10	5.00e-95	341.00
IUUC-Laf-053375	Loxodonta africana	70.94	8.00e-143	499.00
IUUC-Mcc-055248	Macaca mulatta	74.34	2.00e-147	515.00
IUUC-Mla-058976	Melampsora laricipopulina	38.89	5.00e-09	54.30
IUUC-Mga-059968	Meleagris gallopavo	86.42	4.00e-84	303.00
IUUC-Mmr-061376	Microcebus murinus	76.44	1.00e-71	263.00
IUUC-Mdo-062375	Monodelphis domestica	66.57	5.00e-122	431.00
IUUC-Oan-073325	Ornithorhynchus anatinus	82.65	8.00e-100	356.00
IUUC-Oga-087994	Otolemur garnettii	75.70	2.00e-146	512.00
IUUC-Oar-089449	Ovis aries	84.67	8.00e-123	432.00
IUUC-Ptr-090831	Pan troglodytes	71.98	1.00e-143	503.00
IUUC-Pan-091895	Papio anubis	70.61	1.00e-145	509.00
IUUC-Psi-093538	Pelodiscus sinensis	82.50	4.00e-100	357.00
IUUC-Pfo-097114	Poecilia formosa	76.29	2.00e-92	332.00
IUUC-Pab-098228	Pongo abelii	98.83	6.00e-104	369.00
IUUC-Rno-105089	Rattus norvegicus	91.96	2.00e-152	531.00
IUUC-Tgu-117161	Taeniopygia guttata	85.20	4.00e-102	363.00
IUUC-Tru-117642	Takifugu rubripes	72.82	1.00e-87	315.00
IUUC-Tsy-119310	Tarsius syrichta	91.86	4.00e-123	434.00
IUUC-Tni-120672	Tetraodon nigroviridis	71.08	4.00e-85	306.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence