iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004648

UUCD1 version

UUC-AnC-00962

Ensembl Protein ID

ENSACAP00000012288.2

UniProt Accession

H9GIZ7; H9GIZ7_ANOCA

Protein Name

Uncharacterized protein

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000012495.2	ENSACAT00000012540.2	ENSACAP00000012288.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.80e-44	150.8	81	273

Active Site

Position(s)	Description	Evidence
88	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
91	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
267		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          llg+f+d+s+sd
   Q: 81   YIRKTRPDGNCFYRAFGFShlealledgkelqrfkevaakskevlvsqgfteftiedfhntfmdlieqvekqttvseLLGSFNDQSTSD 169
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklv...epeakgeeihifaLaqiLsrpiivvdvdsleskvggillpllfpeek 118
           +lv++Lr+lts ylq+e++ff++fie+++ +kefcq+ +   +p++k    hi+aLaq+L+++i v+++d++e   gg+++p++fpe +
   Q: 170  YLVVYLRLLTSGYLQRENKFFEHFIEGGRSIKEFCQQYIwrwKPMCKESDHHIIALAQALNVSILVEYMDRGE---GGTTNPHVFPEGS 255
           ***********************************9764333899**6666*********************9...9************ PP
   S: 119  lkkpivLlYrsgHYdaLva 137
            +++++LlYr+gHYd+L++
   Q: 256  -EPKVYLLYRPGHYDILYK 273
           .****************96 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

LQAQELQQRG CEALFSSLSG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE KMELSVLYKE 60
YADDDHVYQQ KIKDLLKKYS YIRKTRPDGN CFYRAFGFSH LEALLEDGKE LQRFKEVAAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCAGGCCC AAGAGCTGCA GCAGAGGTGC GACTTCGGCA TTGCTGGCAA GCCTGTGTGT 60
GAGTGAGCAA ATGAGTGAGT GAGTGGGTAA ACGGTTCTGT TTTTCACGTA TATGTATATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	84.42	5.00e-135	473.00
IUUC-Apl-003233	Anas platyrhynchos	61.54	2.00e-19	86.30
IUUC-Aly-005710	Arabidopsis lyrata	38.85	4.00e-47	181.00
IUUC-Ath-007112	Arabidopsis thaliana	40.15	5.00e-46	177.00
IUUC-Afl-008439	Aspergillus flavus	44.44	1.00e-05	43.10
IUUC-Ame-010662	Astyanax mexicanus	81.71	1.00e-122	431.00
IUUC-Bta-013533	Bos taurus	87.74	2.00e-134	471.00
IUUC-Bol-016100	Brassica oleracea	40.60	1.00e-45	176.00
IUUC-Bra-017705	Brassica rapa	37.10	2.00e-39	156.00
IUUC-Cel-018295	Caenorhabditis elegans	32.77	1.00e-34	140.00
IUUC-Cja-019190	Callithrix jacchus	87.74	6.00e-135	473.00
IUUC-Cfa-020430	Canis familiaris	88.72	6.00e-135	473.00
IUUC-Cpo-022355	Cavia porcellus	88.12	2.00e-135	474.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	37.00	5.00e-41	160.00
IUUC-Csa-023286	Chlorocebus sabaeus	84.81	1.00e-132	465.00
IUUC-Cho-024411	Choloepus hoffmanni	43.18	3.00e-25	107.00
IUUC-Cin-025507	Ciona intestinalis	47.22	1.00e-46	179.00
IUUC-Csv-026273	Ciona savignyi	49.22	3.00e-66	244.00
IUUC-Dre-028315	Danio rerio	79.92	5.00e-118	416.00
IUUC-Dno-029165	Dasypus novemcinctus	87.68	1.00e-104	371.00
IUUC-Dor-030943	Dipodomys ordii	88.12	2.00e-135	474.00
IUUC-Dme-031922	Drosophila melanogaster	53.75	1.00e-72	265.00
IUUC-Ete-032296	Echinops telfairi	86.42	2.00e-79	288.00
IUUC-Eca-033695	Equus caballus	87.55	2.00e-133	467.00
IUUC-Eeu-034775	Erinaceus europaeus	43.61	3.00e-52	197.00
IUUC-Fca-036441	Felis catus	85.09	2.00e-135	474.00
IUUC-Gmo-038908	Gadus morhua	79.38	4.00e-119	420.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.12	2.00e-27	117.00
IUUC-Gga-040460	Gallus gallus	77.94	1.00e-125	442.00
IUUC-Gac-042417	Gasterosteus aculeatus	78.26	6.00e-116	409.00
IUUC-Gma-043712	Glycine max	40.07	5.00e-46	177.00
IUUC-Ggo-044552	Gorilla gorilla	87.65	4.00e-81	293.00
IUUC-Hsa-046766	Homo sapiens	87.74	4.00e-135	473.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	88.12	2.00e-135	474.00
IUUC-Lch-050602	Latimeria chalumnae	77.04	7.00e-113	399.00
IUUC-Loc-052003	Lepisosteus oculatus	43.86	3.00e-49	187.00
IUUC-Laf-053705	Loxodonta africana	88.12	2.00e-135	474.00
IUUC-Mcc-055745	Macaca mulatta	82.08	3.00e-131	460.00
IUUC-Meu-056569	Macropus eugenii	76.28	1.00e-117	415.00
IUUC-Mtr-057712	Medicago truncatula	41.18	3.00e-41	161.00
IUUC-Mvi-060358	Microbotryum violaceum	32.73	9.00e-14	70.50
IUUC-Mmr-061123	Microcebus murinus	86.88	1.00e-109	389.00
IUUC-Mdo-062613	Monodelphis domestica	76.28	4.00e-107	380.00
IUUC-Mmu-063658	Mus musculus	88.12	2.00e-135	474.00
IUUC-Mac-065274	Musa acuminata	36.76	4.00e-35	141.00
IUUC-Mpu-066172	Mustela putorius furo	87.74	4.00e-135	473.00
IUUC-Mlu-066966	Myotis lucifugus	88.12	1.00e-135	475.00
IUUC-Nle-069519	Nomascus leucogenys	77.37	1.00e-81	296.00
IUUC-Opr-070761	Ochotona princeps	38.61	1.00e-28	118.00
IUUC-Ont-071901	Oreochromis niloticus	78.35	7.00e-117	412.00
IUUC-Oan-072922	Ornithorhynchus anatinus	44.93	6.00e-55	206.00
IUUC-Ocu-074643	Oryctolagus cuniculus	46.26	2.00e-55	208.00
IUUC-Oni-082026	Oryza nivara	28.72	4.00e-11	62.80
IUUC-Oru-084761	Oryza rufipogon	28.72	4.00e-11	62.80
IUUC-Ola-087331	Oryzias latipes	80.11	1.00e-81	295.00
IUUC-Oga-088064	Otolemur garnettii	87.74	4.00e-135	473.00
IUUC-Oar-089251	Ovis aries	88.98	2.00e-132	464.00
IUUC-Ptr-091430	Pan troglodytes	87.74	8.00e-135	472.00
IUUC-Pan-091969	Papio anubis	44.49	2.00e-53	201.00
IUUC-Psi-093823	Pelodiscus sinensis	87.40	2.00e-134	471.00
IUUC-Pma-094366	Petromyzon marinus	72.11	4.00e-96	343.00
IUUC-Pfo-096734	Poecilia formosa	77.56	9.00e-108	382.00
IUUC-Pab-097919	Pongo abelii	86.43	8.00e-109	385.00
IUUC-Pop-099401	Populus trichocarpa	39.35	6.00e-44	170.00
IUUC-Pca-100252	Procavia capensis	38.95	2.00e-17	82.40
IUUC-Ppe-101977	Prunus persica	40.44	3.00e-46	179.00
IUUC-Pva-102499	Pteropus vampyrus	88.98	5.00e-134	469.00
IUUC-Pgr-103552	Puccinia graminis	30.67	8.60e-02	29.60
IUUC-Rno-105233	Rattus norvegicus	88.12	2.00e-135	474.00
IUUC-Sha-107081	Sarcophilus harrisii	87.36	5.00e-134	470.00
IUUC-Sly-111640	Solanum lycopersicum	40.81	6.00e-45	174.00
IUUC-Sar-113295	Sorex araneus	46.05	7.00e-53	199.00
IUUC-Ssc-116202	Sus scrofa	87.74	4.00e-135	473.00
IUUC-Tru-117664	Takifugu rubripes	74.63	8.00e-115	405.00
IUUC-Tni-120440	Tetraodon nigroviridis	35.93	4.00e-27	114.00
IUUC-Tca-121467	Theobroma cacao	39.64	1.00e-45	176.00
IUUC-Tbe-128116	Tupaia belangeri	86.59	1.00e-81	296.00
IUUC-Ttr-128622	Tursiops truncatus	87.36	8.00e-133	465.00
IUUC-Uma-129443	Ustilago maydis	27.84	3.00e-18	85.90
IUUC-Vvi-131389	Vitis vinifera	42.18	4.00e-48	184.00
IUUC-Xtr-131951	Xenopus tropicalis	41.67	6.00e-49	186.00
IUUC-Xma-134191	Xiphophorus maculatus	77.95	9.00e-109	385.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence