iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088939

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03021621

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000013720.2	ENSOGAT00000013727.2	ENSOGAP00000012296.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-63	213.6	172	657

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 172  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 259
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l
   Q: 260  DSQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 328
           **********************33..................123456788999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 329  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 406
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 407  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddigasstasssgpsqtlpstte 495
           ****8888888888888888888888888888888888888888888888888877777777777777777777777777766665555 PP
   S: 268  peekqke.................................................................................. 274
           +     +                                                                                  
   Q: 496  Q-----Qgapselpstspasvtaissrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrti 579
           0.....14555555555555666666666666666666666666666666666666666777777777777777777778888888888 PP
   S: 275  ..........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                     ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 580  elmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHHESrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 657
           8888888888**************************966667***************99997779************6 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

IRIERGLKQM GASVFNSKHQ QTFLNQLREI TGINDTQILQ QALKDSNGNL ELAVAFLTAK 60
NAKTPQQEET TYYQTALPGN DRYISVGSQA DTNVIDLTGD DKDDLQRAIA LSLAESSRAF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTAGGATAG AAAGAGGGCT GAAGCAAATG GGGGCAAGTG GTCTGTTCAA TTTAGAATCC 60
TTTATGACTG TCACGTTGGA GAGCAGAGCA GTCCTCTTTC TTCCTTGAAA ATCTTAGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	92.74	0.00e+00	1959.00
IUUC-Apl-004030	Anas platyrhynchos	82.83	0.00e+00	1826.00
IUUC-Aca-004753	Anolis carolinensis	65.11	0.00e+00	1010.00
IUUC-Ani-009503	Aspergillus nidulans	33.02	6.00e-11	63.50
IUUC-Ame-010624	Astyanax mexicanus	70.14	0.00e+00	1089.00
IUUC-Bta-013166	Bos taurus	96.92	0.00e+00	1979.00
IUUC-Cel-018346	Caenorhabditis elegans	28.10	4.00e-29	124.00
IUUC-Cja-019150	Callithrix jacchus	95.40	0.00e+00	1408.00
IUUC-Cfa-020649	Canis familiaris	94.49	0.00e+00	1420.00
IUUC-Cpo-021807	Cavia porcellus	91.93	0.00e+00	2041.00
IUUC-Csa-023388	Chlorocebus sabaeus	96.86	0.00e+00	1436.00
IUUC-Cho-024343	Choloepus hoffmanni	82.14	0.00e+00	987.00
IUUC-Cin-025302	Ciona intestinalis	37.56	3.00e-95	342.00
IUUC-Csv-025911	Ciona savignyi	35.06	1.00e-131	464.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	53.19	5.00e-10	60.50
IUUC-Dre-028016	Danio rerio	76.79	0.00e+00	1174.00
IUUC-Dno-029495	Dasypus novemcinctus	91.46	0.00e+00	1422.00
IUUC-Dor-030948	Dipodomys ordii	81.37	0.00e+00	1439.00
IUUC-Fca-035876	Felis catus	96.83	0.00e+00	2001.00
IUUC-Fal-036762	Ficedula albicollis	85.45	0.00e+00	1122.00
IUUC-Gmo-039490	Gadus morhua	71.89	0.00e+00	1521.00
IUUC-Gga-040817	Gallus gallus	85.99	0.00e+00	1354.00
IUUC-Gac-042473	Gasterosteus aculeatus	72.16	0.00e+00	1563.00
IUUC-Ggo-044939	Gorilla gorilla	91.38	0.00e+00	1905.00
IUUC-Hsa-046204	Homo sapiens	95.94	0.00e+00	1971.00
IUUC-Kpa-049349	Komagataella pastoris	28.12	3.00e-10	61.60
IUUC-Lch-049572	Latimeria chalumnae	79.48	0.00e+00	1227.00
IUUC-Loc-052070	Lepisosteus oculatus	75.46	0.00e+00	1200.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	5.00e-12	67.40
IUUC-Laf-054426	Loxodonta africana	96.17	0.00e+00	1843.00
IUUC-Mcc-055858	Macaca mulatta	95.27	0.00e+00	1440.00
IUUC-Mga-059808	Meleagris gallopavo	85.89	0.00e+00	1841.00
IUUC-Mmr-060987	Microcebus murinus	96.54	0.00e+00	1432.00
IUUC-Mmu-064245	Mus musculus	92.07	0.00e+00	1972.00
IUUC-Mpu-066304	Mustela putorius furo	95.69	0.00e+00	1416.00
IUUC-Mlu-067139	Myotis lucifugus	95.58	0.00e+00	2014.00
IUUC-Nle-069075	Nomascus leucogenys	95.85	0.00e+00	1965.00
IUUC-Ont-072150	Oreochromis niloticus	75.16	0.00e+00	1179.00
IUUC-Oan-073054	Ornithorhynchus anatinus	78.88	0.00e+00	1701.00
IUUC-Ocu-074102	Oryctolagus cuniculus	91.97	0.00e+00	1415.00
IUUC-Ola-086529	Oryzias latipes	69.13	0.00e+00	1490.00
IUUC-Oar-090266	Ovis aries	96.34	0.00e+00	1421.00
IUUC-Ptr-090546	Pan troglodytes	95.75	0.00e+00	1967.00
IUUC-Pan-092311	Papio anubis	95.14	0.00e+00	1439.00
IUUC-Psi-093459	Pelodiscus sinensis	90.06	0.00e+00	1164.00
IUUC-Pfo-096726	Poecilia formosa	75.03	0.00e+00	1171.00
IUUC-Pab-097608	Pongo abelii	94.22	0.00e+00	1949.00
IUUC-Pca-100718	Procavia capensis	91.15	0.00e+00	1237.00
IUUC-Pva-103150	Pteropus vampyrus	91.87	0.00e+00	1479.00
IUUC-Rno-105727	Rattus norvegicus	92.63	0.00e+00	1931.00
IUUC-Sha-107051	Sarcophilus harrisii	88.55	0.00e+00	1861.00
IUUC-Sar-113097	Sorex araneus	86.66	0.00e+00	1834.00
IUUC-Sre-115145	Sporisorium reilianum	31.73	1.00e-08	56.60
IUUC-Ssc-115877	Sus scrofa	94.70	0.00e+00	1966.00
IUUC-Tgu-117473	Taeniopygia guttata	79.25	0.00e+00	1697.00
IUUC-Tru-118135	Takifugu rubripes	67.10	0.00e+00	1402.00
IUUC-Tsy-119471	Tarsius syrichta	89.50	0.00e+00	1793.00
IUUC-Tni-120139	Tetraodon nigroviridis	68.11	0.00e+00	1323.00
IUUC-Tbe-127549	Tupaia belangeri	89.92	0.00e+00	1882.00
IUUC-Ttr-128896	Tursiops truncatus	89.75	0.00e+00	1886.00
IUUC-Uma-129338	Ustilago maydis	24.34	2.00e-12	68.90
IUUC-Vda-129742	Verticillium dahliae	23.02	2.00e-11	65.10
IUUC-Vpa-130500	Vicugna pacos	93.30	0.00e+00	1320.00
IUUC-Xtr-132896	Xenopus tropicalis	80.84	0.00e+00	1738.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence