iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001480

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ACTA01085048

Gene Name

USP51; PANDA_022094

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000019294.1	ENSAMET00000021108.1	ENSAMEP00000020339.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.60e-89	298.7	356	698

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 356  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFNAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 440
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k        ++           +e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 441  DAHEFLIAILDVLHRHSKD-------DS---------IGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS 513
           *****************22.......11.........12346899******************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e l ++ k++c++c+++qe+ k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 514  CATFSSqsperadstvsrddhipgipSLTDCLQWFTRPEYLGSNSKIKCSSCQSYQESIKQLTMKKLPVVACFHLKRF--EHVGKQRRK 600
           9876669999********************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           in+ ++fpleLd++pf++s++e+  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l   
   Q: 601  INTFISFPLELDMTPFLASTKESRMKegqpqtdctsnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY-- 687
           *****************99555544467777777777**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 688  -SEGYLLFYHKQ 698
           .********985 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MAQVRETSLP SGSLVRWSSG SGGGASPEEA AEKAGEMEKE AVGAAKACSG LGAEEMKLDP 60
LQEHKPAPEN LTWSDGGGDN KVLPSTPPRC YSSSSPLCPR RKPRPRPQPR ARSRGPPGLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCCAAG TTCGGGAAAC TTCCTTGCCC TCCGGCTCTT TGGTCCGCTG GAGCTCGGGA 60
AGTGGGGGAG GAGCCTCTCC CGAGGAGGCG GCTGAAAAGG CGGGGGAAAT GGAGAAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

aml:100470910

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ang-009694	Aspergillus niger	31.46	2.00e-57	216.00
IUUC-Bol-016509	Brassica oleracea	38.35	5.00e-75	275.00
IUUC-Bra-016962	Brassica rapa	37.86	9.00e-74	270.00
IUUC-Csa-023824	Chlorocebus sabaeus	92.78	0.00e+00	989.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	29.98	4.00e-55	209.00
IUUC-Eca-033872	Equus caballus	92.42	0.00e+00	985.00
IUUC-Fca-035534	Felis catus	91.65	0.00e+00	1019.00
IUUC-Gma-043469	Glycine max	35.00	3.00e-89	322.00
IUUC-Ggo-045109	Gorilla gorilla	91.55	0.00e+00	958.00
IUUC-Hsa-045765	Homo sapiens	93.55	0.00e+00	994.00
IUUC-Hvu-047739	Hordeum vulgare	38.57	2.00e-69	255.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	91.67	0.00e+00	936.00
IUUC-Mcc-055420	Macaca mulatta	92.82	0.00e+00	996.00
IUUC-Mla-059185	Melampsora laricipopulina	32.87	2.00e-41	163.00
IUUC-Mmr-061690	Microcebus murinus	92.83	0.00e+00	1003.00
IUUC-Mmu-063435	Mus musculus	79.10	0.00e+00	817.00
IUUC-Mac-065419	Musa acuminata	34.48	1.00e-75	276.00
IUUC-Mpu-065679	Mustela putorius furo	93.04	0.00e+00	1080.00
IUUC-Mlu-067084	Myotis lucifugus	91.11	0.00e+00	973.00
IUUC-Nle-069859	Nomascus leucogenys	93.36	0.00e+00	993.00
IUUC-Ocu-074365	Oryctolagus cuniculus	85.03	0.00e+00	1020.00
IUUC-Ptr-091479	Pan troglodytes	86.78	0.00e+00	1071.00
IUUC-Pan-091707	Papio anubis	92.59	0.00e+00	986.00
IUUC-Pab-097894	Pongo abelii	93.40	0.00e+00	998.00
IUUC-Rno-105644	Rattus norvegicus	80.38	0.00e+00	825.00
IUUC-Sar-113426	Sorex araneus	80.80	0.00e+00	814.00
IUUC-Ssc-115500	Sus scrofa	90.72	0.00e+00	966.00
IUUC-Tsy-119413	Tarsius syrichta	90.94	0.00e+00	954.00
IUUC-Tca-121154	Theobroma cacao	38.84	3.00e-92	332.00
IUUC-Vda-129829	Verticillium dahliae	34.53	2.00e-35	142.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence