iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065679

Ensembl Protein ID

ENSMPUP00000019870.1

UniProt Accession

M3Z8F6; M3Z8F6_MUSPF

Genbank Protein ID

ENSMPUP00000019870

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEYP01105234

Gene Name

USP51

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000020001.1	ENSMPUT00000020153.1	ENSMPUP00000019870.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-89	299.8	355	697

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 355  GLINLGNTCFMNCIVQALTHIPLLKNFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 439
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k+                 s  +e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 440  DAHEFLIAILDVLHRHSKE----------------DSVVQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS 512
           *****************33................344556899*******************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 513  CATFGSqsperadstvsrddhipgipSLTDCLQWFTRPEYLGSSSKIKCSTCQSYQESTKQLTMKKLPIVACFHLKRF--EHVGKQRRK 599
           977666889999******************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           in+ ++fpleLd++pf++s++e+  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l   
   Q: 600  INTFISFPLELDMTPFLASTKESRMKegqpptdctsnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY-- 686
           *****************99555544467777777777**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 687  -SEGYLLFYHKQ 697
           .********985 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MAQVRDLPSG SLVRWSSGGG GGASPEEAAE KAGEMEKEAV GAAKACSGQG AEEMKLEPLQ 60
EHKPPPENLT WSDSGGDKNV FPSTPPRCYS SSSPLCPRRK PRPRPQPRAR SRGPPGLSAP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCCAAG TTCGGGACTT GCCCTCCGGC TCTTTGGTCC GCTGGAGCTC GGGAGGTGGG 60
GGAGGAGCCT CTCCCGAGGA GGCGGCTGAA AAGGCGGGGG AAATGGAGAA GGAGGCGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001480	Ailuropoda melanoleuca	95.83	0.00e+00	1018.00
IUUC-Bol-016509	Brassica oleracea	37.71	8.00e-75	275.00
IUUC-Cja-019402	Callithrix jacchus	91.98	0.00e+00	690.00
IUUC-Csa-023824	Chlorocebus sabaeus	93.55	0.00e+00	995.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	30.30	1.00e-55	211.00
IUUC-Eca-033872	Equus caballus	93.37	0.00e+00	994.00
IUUC-Fca-035534	Felis catus	92.28	0.00e+00	1024.00
IUUC-Ggo-045109	Gorilla gorilla	91.95	0.00e+00	962.00
IUUC-Hsa-045765	Homo sapiens	94.31	0.00e+00	1006.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	93.37	0.00e+00	942.00
IUUC-Mcc-055420	Macaca mulatta	93.58	0.00e+00	1002.00
IUUC-Mla-059185	Melampsora laricipopulina	33.71	2.00e-43	170.00
IUUC-Mmr-061690	Microcebus murinus	93.40	0.00e+00	1009.00
IUUC-Mmu-063435	Mus musculus	79.47	0.00e+00	820.00
IUUC-Mac-065419	Musa acuminata	33.67	6.00e-74	271.00
IUUC-Mlu-067084	Myotis lucifugus	93.58	0.00e+00	980.00
IUUC-Nle-069859	Nomascus leucogenys	94.12	0.00e+00	1004.00
IUUC-Ocu-074365	Oryctolagus cuniculus	83.78	0.00e+00	1009.00
IUUC-Ptr-091479	Pan troglodytes	94.12	0.00e+00	1006.00
IUUC-Pan-091707	Papio anubis	93.36	0.00e+00	993.00
IUUC-Pab-097894	Pongo abelii	94.15	0.00e+00	1008.00
IUUC-Rno-105644	Rattus norvegicus	81.13	0.00e+00	830.00
IUUC-Sar-113426	Sorex araneus	74.71	0.00e+00	865.00
IUUC-Ssc-115500	Sus scrofa	91.67	0.00e+00	972.00
IUUC-Tsy-119413	Tarsius syrichta	91.70	0.00e+00	956.00
IUUC-Tca-121154	Theobroma cacao	39.54	3.00e-91	329.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence