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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046953
UUCD1 version UUC-HoS-00308
Ensembl Protein ID ENSP00000339030.5
UniProt Accession Q96JP5; A6NHC4; A8MSG7; Q86V47; Q96JP4; Q96QA3; ZFP91_HUMAN
Genbank Protein ID BAB63373.1; BAB63374.1; EAW73811.1; AAH51743.1; AAL09963.1
Protein Name E3 ubiquitin-protein ligase ZFP91; RING-type E3 ubiquitin transferase ZFP91; Zinc finger protein 757; Zinc finger protein 91 homolog
Genbank Nucleotide ID AB056107; AB057443; AP001350; BC051743; AF310246
Gene Name ZFP91; ZNF757; FKSG11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000186660.14 ENST00000316059.6 ENSP00000339030.5
Annotation
Cancer Mutation
TCGAICGCCOSMICIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMPHOSIDABioGRID
mUbiSiDa
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 20682767
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
 Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
Protein Sequence
(Fasta)
MPGETEEPRP PEQQDQEGGE AAKAAPEEPQ QRPPEAVAAA PAGTTSSRVL RGGRDRGRAA 60
AAAAAAAVSR RRKAEYPRRR RSSPSARPPD VPGQQPQAAK SPSPVQGKKS PRLLCIEKVT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046953|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGTGGGGG GGGCGCCCTC GGAGCCGGGC GGAGGGGAGG GGGGAAAGAG GAGCGCAGGG 60
TGAGAGTGAG CCGCAGGCTT CGGGAGGCGA GGGGGCGGGG GGAGCAGCGC CGAGGCCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046953|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004039--Rubredoxin-type_fold
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
SMART

SM00355--ZnF_C2H2
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0070534--P:protein K63-linked ubiquitination
KEGG hsa:80829
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001568 Ailuropoda melanoleuca 95.87 6.00e-179 620.00
IUUC-Apl-003922 Anas platyrhynchos 89.35 4.00e-121 428.00
IUUC-Aca-004295 Anolis carolinensis 89.73 4.00e-133 468.00
IUUC-Ame-011459 Astyanax mexicanus 85.09 8.00e-81 295.00
IUUC-Bta-013396 Bos taurus 90.75 5.00e-164 570.00
IUUC-Cja-018863 Callithrix jacchus 99.17 0.00e+00 695.00
IUUC-Cpo-021683 Cavia porcellus 90.78 4.00e-177 614.00
IUUC-Csa-024073 Chlorocebus sabaeus 99.58 0.00e+00 689.00
IUUC-Cho-024818 Choloepus hoffmanni 82.93 9.00e-159 553.00
IUUC-Dre-028207 Danio rerio 84.00 1.00e-90 327.00
IUUC-Dno-029304 Dasypus novemcinctus 94.74 5.00e-168 584.00
IUUC-Dor-030107 Dipodomys ordii 80.30 5.00e-169 587.00
IUUC-Ete-032699 Echinops telfairi 92.47 5.00e-82 298.00
IUUC-Eca-034194 Equus caballus 95.64 0.00e+00 628.00
IUUC-Eeu-034581 Erinaceus europaeus 91.47 1.00e-160 559.00
IUUC-Fca-035744 Felis catus 96.57 5.00e-171 593.00
IUUC-Fal-037428 Ficedula albicollis 88.97 6.00e-120 424.00
IUUC-Gga-040268 Gallus gallus 89.45 1.00e-116 412.00
IUUC-Gac-042035 Gasterosteus aculeatus 86.70 1.00e-90 325.00
IUUC-Ggo-045144 Gorilla gorilla 90.64 0.00e+00 700.00
IUUC-Itr-048235 Ictidomys tridecemlineatus 90.62 5.00e-147 514.00
IUUC-Lch-049423 Latimeria chalumnae 67.87 1.00e-82 300.00
IUUC-Loc-052385 Lepisosteus oculatus 98.25 9.00e-93 333.00
IUUC-Laf-054089 Loxodonta africana 88.12 4.00e-174 604.00
IUUC-Mcc-055006 Macaca mulatta 99.79 0.00e+00 690.00
IUUC-Meu-056340 Macropus eugenii 90.39 4.00e-168 584.00
IUUC-Mga-059191 Meleagris gallopavo 90.11 2.00e-122 432.00
IUUC-Mmr-061320 Microcebus murinus 95.87 1.00e-167 582.00
IUUC-Mdo-062414 Monodelphis domestica 89.70 8.00e-163 566.00
IUUC-Mmu-063454 Mus musculus 88.85 2.00e-165 575.00
IUUC-Mpu-066297 Mustela putorius furo 96.66 0.00e+00 656.00
IUUC-Mlu-067775 Myotis lucifugus 93.91 8.00e-170 590.00
IUUC-Nle-069237 Nomascus leucogenys 100.00 2.00e-179 622.00
IUUC-Opr-070296 Ochotona princeps 98.48 7.00e-135 473.00
IUUC-Ont-071269 Oreochromis niloticus 96.03 1.00e-87 316.00
IUUC-Oan-073394 Ornithorhynchus anatinus 87.02 7.00e-114 403.00
IUUC-Ocu-073924 Oryctolagus cuniculus 95.88 3.00e-171 595.00
IUUC-Ola-087465 Oryzias latipes 95.97 7.00e-87 313.00
IUUC-Oga-087989 Otolemur garnettii 95.02 0.00e+00 629.00
IUUC-Oar-089920 Ovis aries 83.49 5.00e-138 484.00
IUUC-Ptr-090723 Pan troglodytes 100.00 0.00e+00 691.00
IUUC-Pan-092137 Papio anubis 99.79 0.00e+00 689.00
IUUC-Psi-093233 Pelodiscus sinensis 80.23 6.00e-109 387.00
IUUC-Pfo-096965 Poecilia formosa 95.15 5.00e-91 328.00
IUUC-Pca-100601 Procavia capensis 95.41 0.00e+00 631.00
IUUC-Pva-103026 Pteropus vampyrus 94.51 4.00e-134 471.00
IUUC-Rno-105705 Rattus norvegicus 88.79 3.00e-176 611.00
IUUC-Sha-107207 Sarcophilus harrisii 92.22 3.00e-170 591.00
IUUC-Sar-113184 Sorex araneus 80.09 7.00e-172 596.00
IUUC-Ssc-115994 Sus scrofa 96.34 3.00e-170 591.00
IUUC-Tgu-117118 Taeniopygia guttata 87.50 2.00e-116 412.00
IUUC-Tru-118573 Takifugu rubripes 95.30 2.00e-87 316.00
IUUC-Tsy-119070 Tarsius syrichta 95.19 4.00e-169 587.00
IUUC-Tni-119814 Tetraodon nigroviridis 95.30 3.00e-87 315.00
IUUC-Tbe-127969 Tupaia belangeri 82.15 3.00e-154 538.00
IUUC-Ttr-128207 Tursiops truncatus 88.70 6.00e-164 570.00
IUUC-Vpa-130522 Vicugna pacos 95.84 7.00e-171 593.00
IUUC-Xtr-131894 Xenopus tropicalis 72.27 4.00e-90 323.00
Created Date 25-Jun-2017

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