iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028344

UUCD1 version

UUC-DaR-00157

Ensembl Protein ID

ENSDARP00000131425.1

UniProt Accession

A0A0G2KGJ0; A0A0G2KGJ0_DANRE

Genbank Protein ID

ENSDARP00000131425

Protein Name

Kelch-like protein 12

Genbank Nucleotide ID

CABZ01087210

Gene Name

klhl12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000100631.1	ENSDART00000158788.1	ENSDARP00000131425.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.40e-18	66.7	29	92
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.10e-12	44.8	128	158

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +D++l v+g+ f+ah+ivLaa+S++F a+f++el e+  k+ v+i+++ ++ ++ ll+F+Yt ++
   Q: 29   CDITLRVEGTDFPAHRIVLAACSDYFCAMFTSELAEKG-KSFVDIQGLTASTMEILLDFVYTETV 92
           8***********************************98.***********************875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++Nclgi++fA++++c dL++aa+ f +khF
   Q: 128  PSNCLGIRDFAETHNCLDLMQAAELFSQKHF 158
           89****************************9 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MAPKDIMTNS HAKSILNAMN ALRKSNTLCD ITLRVEGTDF PAHRIVLAAC SDYFCAMFTS 60
ELAEKGKSFV DIQGLTASTM EILLDFVYTE TVLVTVENVQ ELLPAACLLQ LKGVKRACCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGGGGATG CGCGCACACG TGAGCGCTGC TCTTTTCATT GCTGGAGTGA AATTGAGTTT 60
ACACCTGCGA TGGTTTTCAT GTAAAGGGTG CAACAGATGT CCAAATAGAC CACCGTCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030134--C:ER to Golgi transport vesicle
GO:0000139--C:Golgi membrane
GO:0048208--P:COPII vesicle coating
GO:0006513--P:protein monoubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002301	Ailuropoda melanoleuca	88.20	4.00e-162	564.00
IUUC-Apl-003339	Anas platyrhynchos	88.26	5.00e-140	491.00
IUUC-Aca-004418	Anolis carolinensis	88.03	1.00e-164	572.00
IUUC-Ame-011906	Astyanax mexicanus	66.04	9.00e-113	400.00
IUUC-Bta-012979	Bos taurus	87.06	2.00e-164	572.00
IUUC-Bci-013669	Botrytis cinerea	37.14	5.00e-06	48.50
IUUC-Cja-019582	Callithrix jacchus	88.67	7.00e-167	580.00
IUUC-Cfa-020716	Canis familiaris	89.00	5.00e-167	581.00
IUUC-Cpo-022013	Cavia porcellus	88.67	4.00e-167	581.00
IUUC-Csa-023424	Chlorocebus sabaeus	88.67	3.00e-167	581.00
IUUC-Cho-024586	Choloepus hoffmanni	59.22	1.00e-99	357.00
IUUC-Dno-028854	Dasypus novemcinctus	89.00	1.00e-167	583.00
IUUC-Dor-030403	Dipodomys ordii	89.00	2.00e-167	582.00
IUUC-Ete-032963	Echinops telfairi	88.71	4.00e-132	464.00
IUUC-Eca-033282	Equus caballus	89.00	1.00e-167	583.00
IUUC-Fca-035487	Felis catus	89.00	1.00e-167	583.00
IUUC-Fal-037059	Ficedula albicollis	88.93	1.00e-163	569.00
IUUC-Gmo-039564	Gadus morhua	94.17	3.00e-177	614.00
IUUC-Gga-040629	Gallus gallus	88.60	2.00e-164	572.00
IUUC-Gac-042526	Gasterosteus aculeatus	95.15	6.00e-178	617.00
IUUC-Ggo-044839	Gorilla gorilla	88.67	4.00e-167	581.00
IUUC-Hsa-046742	Homo sapiens	88.67	4.00e-167	581.00
IUUC-Itr-048958	Ictidomys tridecemlineatus	89.00	1.00e-167	583.00
IUUC-Lch-049540	Latimeria chalumnae	87.70	4.00e-164	571.00
IUUC-Loc-051923	Lepisosteus oculatus	90.61	3.00e-169	588.00
IUUC-Laf-054370	Loxodonta africana	89.00	9.00e-168	583.00
IUUC-Mcc-054852	Macaca mulatta	88.67	4.00e-167	581.00
IUUC-Mga-059486	Meleagris gallopavo	84.77	7.00e-130	457.00
IUUC-Mmr-061777	Microcebus murinus	89.00	4.00e-167	581.00
IUUC-Mdo-061990	Monodelphis domestica	89.32	1.00e-167	583.00
IUUC-Mmu-064053	Mus musculus	88.67	4.00e-167	581.00
IUUC-Mpu-066623	Mustela putorius furo	89.00	1.00e-166	579.00
IUUC-Mlu-067648	Myotis lucifugus	88.67	1.00e-166	579.00
IUUC-Nle-069714	Nomascus leucogenys	88.35	1.00e-166	580.00
IUUC-Opr-071143	Ochotona princeps	89.32	1.00e-167	582.00
IUUC-Ont-071848	Oreochromis niloticus	96.44	2.00e-180	625.00
IUUC-Oan-073041	Ornithorhynchus anatinus	87.77	3.00e-146	511.00
IUUC-Ocu-074379	Oryctolagus cuniculus	89.00	5.00e-167	581.00
IUUC-Ola-087469	Oryzias latipes	96.76	0.00e+00	627.00
IUUC-Oga-088004	Otolemur garnettii	89.36	3.00e-125	441.00
IUUC-Oar-090144	Ovis aries	87.70	1.00e-164	573.00
IUUC-Ptr-091406	Pan troglodytes	88.67	4.00e-167	581.00
IUUC-Pan-092762	Papio anubis	88.67	4.00e-167	581.00
IUUC-Psi-093391	Pelodiscus sinensis	88.03	7.00e-165	573.00
IUUC-Pfo-096404	Poecilia formosa	96.12	5.00e-180	624.00
IUUC-Pab-098425	Pongo abelii	87.38	1.00e-163	569.00
IUUC-Pca-101093	Procavia capensis	88.97	8.00e-156	543.00
IUUC-Pva-102239	Pteropus vampyrus	87.32	2.00e-144	506.00
IUUC-Rno-104921	Rattus norvegicus	89.00	1.00e-167	583.00
IUUC-Sha-106625	Sarcophilus harrisii	89.32	3.00e-167	582.00
IUUC-Sar-113468	Sorex araneus	74.76	2.00e-133	469.00
IUUC-Ssc-116106	Sus scrofa	88.67	1.00e-166	579.00
IUUC-Tgu-117402	Taeniopygia guttata	80.00	3.00e-138	485.00
IUUC-Tru-117546	Takifugu rubripes	94.82	8.00e-177	613.00
IUUC-Tsy-118802	Tarsius syrichta	79.22	7.00e-142	497.00
IUUC-Tni-119999	Tetraodon nigroviridis	95.08	6.00e-174	604.00
IUUC-Tbe-127987	Tupaia belangeri	88.67	9.00e-167	580.00
IUUC-Ttr-128613	Tursiops truncatus	77.67	4.00e-140	491.00
IUUC-Xtr-132401	Xenopus tropicalis	87.70	6.00e-164	570.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence