iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000006556.4	ENSCAFT00000049144.2	ENSCAFP00000036296.1
ENSCAFG00000006556.4	ENSCAFT00000010576.4	ENSCAFP00000009806.3
ENSCAFG00000006556.4	ENSCAFT00000044849.1	ENSCAFP00000035974.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-62	204.5	749	784
UBD/Beta-Prp	8.10e-114	380.1	677	938

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+++ +
   Q: 749  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDVKSAN 784
           8***********777****************98765 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdk 108
           ++++at s d+++k+w+  tg l++ + +h+++v+++ f +++   +l+t+s+D ++k+wdl++ +c  t+ gh++sv  ++fsp+++ 
   Q: 677  DRFIATCSVDKKVKIWNSMTGGLVHVYDEHSEQVNCCHFTNNSHylLLATASSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL 765
           7899**************************************999999***************************************** PP
   S: 109  lvsGshdrtirvwdletgqclee............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvys 185
           l+s s+d t+++wd+++  + ++            +++  + +v c +++ dg  ++ +++ +++ l+d+ tg ll +   gh++ ++ 
   Q: 766  LASCSADGTLKLWDVKSANERKSinvkqfflnseePQEDMEVIVKCCSWSADGTRIMVAAK-NKIFLFDIHTGGLLAEIHTGHHSTIQY 853
           *******************99999**********99999999***********66665554.5799*************888******* PP
   S: 186  lsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav 272
            +f+++    v +     v+lw++ +   v  ++gh ++v +v fsp++  +++ s+D++ir+W +++   ++++ l  ++ i v +
   Q: 854  CDFSPQNHLAVVALSQCCVELWNMDSCLKVADCRGHLSWVHCVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAIVL--KQEIDVVF 938
           *****8766666667779**********************************************7666555555544..33444444 PP

Organism

Canis familiaris

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QYREALEKDI KTSYIMDRMI NDGVLTISEE EKVKNEPTQQ QRAALLIKTI 60
LKKDNYSYIS FYNALIHEGY KDLAALLHSG IPVISSSNGG KDSVGGITSH VKTVLCEGGV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAACTCCAT GACCAGTGTG GGGTTTGAAC TCATGACCCT GAGATCAAGA GTCACATGCT 60
CTATTAACTG AGCCAGCTGG GTACCCCTCT TAACTCTTTT TGTGGATATT TTTGCCTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR024977--Apc4_WD40_dom
IPR001315--CARD
IPR003143--Cyt_cd1_C
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	92.87	0.00e+00	2353.00
IUUC-Apl-004201	Anas platyrhynchos	67.41	0.00e+00	1697.00
IUUC-Aca-004638	Anolis carolinensis	66.22	0.00e+00	1690.00
IUUC-Ani-009285	Aspergillus nidulans	25.65	1.00e-67	251.00
IUUC-Ame-011062	Astyanax mexicanus	52.08	0.00e+00	1298.00
IUUC-Bta-012865	Bos taurus	86.45	0.00e+00	2220.00
IUUC-Cja-018815	Callithrix jacchus	76.54	0.00e+00	1899.00
IUUC-Cpo-021524	Cavia porcellus	83.68	0.00e+00	2117.00
IUUC-Csa-023861	Chlorocebus sabaeus	86.69	0.00e+00	2184.00
IUUC-Cho-024484	Choloepus hoffmanni	81.46	0.00e+00	1221.00
IUUC-Dre-028006	Danio rerio	50.84	0.00e+00	1194.00
IUUC-Dno-029591	Dasypus novemcinctus	87.24	0.00e+00	2238.00
IUUC-Dor-030237	Dipodomys ordii	76.69	0.00e+00	1079.00
IUUC-Ete-032620	Echinops telfairi	76.91	0.00e+00	971.00
IUUC-Eca-033569	Equus caballus	87.24	0.00e+00	2214.00
IUUC-Eeu-035354	Erinaceus europaeus	67.84	0.00e+00	628.00
IUUC-Fca-036337	Felis catus	90.81	0.00e+00	2330.00
IUUC-Fal-037077	Ficedula albicollis	67.27	0.00e+00	1693.00
IUUC-Gmo-039687	Gadus morhua	48.03	0.00e+00	833.00
IUUC-Ggr-039828	Gaeumannomyces graminis	22.84	1.00e-38	156.00
IUUC-Gga-040299	Gallus gallus	66.06	0.00e+00	1706.00
IUUC-Gac-041762	Gasterosteus aculeatus	49.38	0.00e+00	1204.00
IUUC-Ggo-045563	Gorilla gorilla	87.08	0.00e+00	2197.00
IUUC-Hsa-046771	Homo sapiens	86.69	0.00e+00	2191.00
IUUC-Lch-050200	Latimeria chalumnae	61.93	0.00e+00	1529.00
IUUC-Loc-052090	Lepisosteus oculatus	56.51	0.00e+00	1404.00
IUUC-Laf-053861	Loxodonta africana	85.83	0.00e+00	2191.00
IUUC-Mcc-055543	Macaca mulatta	87.40	0.00e+00	2201.00
IUUC-Meu-056688	Macropus eugenii	76.21	0.00e+00	1919.00
IUUC-Mga-059243	Meleagris gallopavo	66.64	0.00e+00	1727.00
IUUC-Mmr-061134	Microcebus murinus	80.78	0.00e+00	1853.00
IUUC-Mdo-062913	Monodelphis domestica	75.10	0.00e+00	1922.00
IUUC-Mmu-063811	Mus musculus	82.49	0.00e+00	2128.00
IUUC-Mpu-066780	Mustela putorius furo	92.23	0.00e+00	2289.00
IUUC-Mlu-067276	Myotis lucifugus	86.14	0.00e+00	2205.00
IUUC-Nle-069129	Nomascus leucogenys	86.61	0.00e+00	2186.00
IUUC-Opr-071007	Ochotona princeps	65.08	0.00e+00	988.00
IUUC-Ont-071348	Oreochromis niloticus	52.32	0.00e+00	1318.00
IUUC-Oan-072717	Ornithorhynchus anatinus	77.31	0.00e+00	1989.00
IUUC-Ocu-074286	Oryctolagus cuniculus	85.81	0.00e+00	1850.00
IUUC-Ola-086895	Oryzias latipes	48.16	0.00e+00	1102.00
IUUC-Oga-088678	Otolemur garnettii	85.97	0.00e+00	2179.00
IUUC-Oar-089359	Ovis aries	85.90	0.00e+00	2189.00
IUUC-Ptr-091062	Pan troglodytes	86.69	0.00e+00	2192.00
IUUC-Pan-092528	Papio anubis	84.84	0.00e+00	1237.00
IUUC-Psi-093430	Pelodiscus sinensis	71.30	0.00e+00	1818.00
IUUC-Pma-094690	Petromyzon marinus	38.38	9.00e-146	510.00
IUUC-Pfo-097204	Poecilia formosa	51.41	0.00e+00	1266.00
IUUC-Pab-097690	Pongo abelii	87.16	0.00e+00	2197.00
IUUC-Pca-100778	Procavia capensis	69.29	0.00e+00	1060.00
IUUC-Pva-102870	Pteropus vampyrus	85.06	0.00e+00	1995.00
IUUC-Rno-104889	Rattus norvegicus	82.49	0.00e+00	2097.00
IUUC-Sha-107465	Sarcophilus harrisii	75.32	0.00e+00	1960.00
IUUC-Sar-113268	Sorex araneus	90.03	0.00e+00	668.00
IUUC-Ssc-115654	Sus scrofa	86.13	0.00e+00	2212.00
IUUC-Tgu-117302	Taeniopygia guttata	67.59	0.00e+00	1713.00
IUUC-Tru-118363	Takifugu rubripes	51.37	0.00e+00	1290.00
IUUC-Tsy-119007	Tarsius syrichta	81.93	0.00e+00	2066.00
IUUC-Tni-120910	Tetraodon nigroviridis	49.96	0.00e+00	1219.00
IUUC-Tbe-127413	Tupaia belangeri	72.77	0.00e+00	1283.00
IUUC-Ttr-129213	Tursiops truncatus	80.98	0.00e+00	2021.00
IUUC-Vpa-130146	Vicugna pacos	81.90	0.00e+00	1528.00
IUUC-Xtr-132559	Xenopus tropicalis	58.74	0.00e+00	1445.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence