iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062923

UUCD1 version

UUC-MoD-00639

Ensembl Protein ID

ENSMODP00000018764.3

UniProt Accession

F7BXS6; F7BXS6_MONDO

Protein Name

Uncharacterized protein

Gene Name

KLHL3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000014989.3	ENSMODT00000019101.3	ENSMODP00000018764.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.60e-22	77.8	50	116
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.40e-11	42.7	149	180

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv++v +++e++ah++vLaa+S++F a+f+++++esk  +++eikdv+ + ++ l++++Yt +++ +
   Q: 50   CDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESK-AKKIEIKDVDGQTLSKLIDYIYTAEIEVT 116
           8*************************************.************************99876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           + Nclgi++fAd ++c++L ++a+ ++++hF+
   Q: 149  PTNCLGIRAFADVHTCTELLQQANAYAEQHFP 180
           78*****************************6 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MEGESIKPSS QSLVEGEDEE KDQKTITVNP AHMGKAFKVM NELRSKQLLC DVMIVAEDVE 60
IEAHRVVLAA CSPYFCAMFT GDMSESKAKK IEIKDVDGQT LSKLIDYIYT AEIEVTEENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATATTTGGT CTATATTTAC AGGGATAGTA TTATTTATTG TCTATTTTTG TTTCATGTTG 60
CTCCCTGGTA TCTCAGCCTC AAAATGATTC TTCTCTGTCA TTCTGGAAAC TTTTCATGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0072156--P:distal tubule morphogenesis
GO:0050801--P:ion homeostasis
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0070294--P:renal sodium ion absorption

KEGG

mdo:100013485

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001632	Ailuropoda melanoleuca	96.93	0.00e+00	1158.00
IUUC-Apl-003965	Anas platyrhynchos	94.85	0.00e+00	1110.00
IUUC-Aca-004912	Anolis carolinensis	93.70	0.00e+00	1097.00
IUUC-Ate-010500	Aspergillus terreus	25.56	1.00e-19	90.90
IUUC-Ame-010670	Astyanax mexicanus	79.56	0.00e+00	947.00
IUUC-Bta-013354	Bos taurus	97.44	0.00e+00	1165.00
IUUC-Bra-017771	Brassica rapa	29.82	7.00e-13	69.70
IUUC-Cel-018136	Caenorhabditis elegans	42.93	9.00e-132	464.00
IUUC-Cja-019183	Callithrix jacchus	93.21	0.00e+00	1019.00
IUUC-Cfa-020465	Canis familiaris	95.88	0.00e+00	1140.00
IUUC-Cpo-022115	Cavia porcellus	97.09	0.00e+00	1164.00
IUUC-Csa-024219	Chlorocebus sabaeus	97.44	0.00e+00	1172.00
IUUC-Csv-026032	Ciona savignyi	60.27	0.00e+00	703.00
IUUC-Cgl-026620	Colletotrichum gloeosporioides	30.74	4.00e-25	108.00
IUUC-Dre-028524	Danio rerio	74.60	0.00e+00	949.00
IUUC-Dno-029075	Dasypus novemcinctus	98.93	0.00e+00	1140.00
IUUC-Dor-030156	Dipodomys ordii	80.20	0.00e+00	939.00
IUUC-Ete-033064	Echinops telfairi	82.08	0.00e+00	852.00
IUUC-Eca-033887	Equus caballus	96.25	0.00e+00	1157.00
IUUC-Eeu-035244	Erinaceus europaeus	77.68	0.00e+00	918.00
IUUC-Fca-035375	Felis catus	96.76	0.00e+00	1153.00
IUUC-Fal-037119	Ficedula albicollis	96.58	0.00e+00	1075.00
IUUC-Fso-038219	Fusarium solani	40.32	2.00e-10	57.00
IUUC-Gga-041094	Gallus gallus	95.98	0.00e+00	1105.00
IUUC-Gac-042585	Gasterosteus aculeatus	79.26	0.00e+00	914.00
IUUC-Ggo-045485	Gorilla gorilla	96.78	0.00e+00	1162.00
IUUC-Hsa-046717	Homo sapiens	97.27	0.00e+00	1171.00
IUUC-Itr-048605	Ictidomys tridecemlineatus	96.74	0.00e+00	1159.00
IUUC-Lch-050246	Latimeria chalumnae	87.69	0.00e+00	1013.00
IUUC-Laf-053700	Loxodonta africana	97.06	0.00e+00	1144.00
IUUC-Mcc-054732	Macaca mulatta	98.81	0.00e+00	1018.00
IUUC-Mga-059994	Meleagris gallopavo	95.45	0.00e+00	1000.00
IUUC-Mmu-063842	Mus musculus	95.90	0.00e+00	1152.00
IUUC-Mpu-066380	Mustela putorius furo	96.59	0.00e+00	1161.00
IUUC-Mlu-067922	Myotis lucifugus	96.71	0.00e+00	1138.00
IUUC-Nle-069761	Nomascus leucogenys	97.27	0.00e+00	1172.00
IUUC-Opr-070287	Ochotona princeps	88.42	0.00e+00	1034.00
IUUC-Ont-071654	Oreochromis niloticus	79.14	0.00e+00	957.00
IUUC-Ocu-074957	Oryctolagus cuniculus	96.07	0.00e+00	1144.00
IUUC-Ola-086853	Oryzias latipes	77.61	0.00e+00	912.00
IUUC-Oga-088559	Otolemur garnettii	96.26	0.00e+00	1154.00
IUUC-Oar-089925	Ovis aries	97.28	0.00e+00	1172.00
IUUC-Ptr-091487	Pan troglodytes	97.27	0.00e+00	1171.00
IUUC-Pan-091705	Papio anubis	97.44	0.00e+00	1172.00
IUUC-Psi-093478	Pelodiscus sinensis	92.19	0.00e+00	1060.00
IUUC-Pfo-097450	Poecilia formosa	79.31	0.00e+00	902.00
IUUC-Pab-097618	Pongo abelii	97.44	0.00e+00	1174.00
IUUC-Pca-100739	Procavia capensis	88.53	0.00e+00	657.00
IUUC-Sha-106935	Sarcophilus harrisii	99.73	0.00e+00	760.00
IUUC-Ssc-115599	Sus scrofa	97.42	0.00e+00	1161.00
IUUC-Tgu-117001	Taeniopygia guttata	95.40	0.00e+00	1087.00
IUUC-Tru-118078	Takifugu rubripes	78.28	0.00e+00	952.00
IUUC-Tsy-119161	Tarsius syrichta	84.91	0.00e+00	894.00
IUUC-Tni-120888	Tetraodon nigroviridis	76.43	0.00e+00	892.00
IUUC-Tbe-127285	Tupaia belangeri	82.93	0.00e+00	672.00
IUUC-Ttr-128884	Tursiops truncatus	80.59	6.00e-149	520.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence