iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15258615
ULD/UDP/UFD/UBX	UBX	15258615

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.00016	20.2	6	41
ULD/UDP/UFD/UBX	6.60e-17	60.3	346	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 4    edkleqlve.MGFdreealqaLraannnleaAveyLl 39
            + ++q+++ ++ + + a+q L + +++l++A++ ++
   Q: 6    DETIQQFMAlTNVSHNIAVQYLSE-FGDLNEALNSYY 41
           689*********************.*********987 PP

ULD/UDP/UFD/UBX

   S: 3    teqatlqiRlpdGkrlvrkFpssttleqiyqfve.yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           ++ + +qiR+++Gkr v +++s++t++ +y++v+ ++++++s +F+L+ +fP ++++++e   tl++a+L++s ++++
   Q: 346  QGDTSIQIRYANGKREVLHCNSTDTVKFLYEHVTsNANTDPSRNFTLNYAFPIKPISNDET--TLKDADLLNSVVVQR 421
           6799*********************************************************..***********9986 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Direct or indirect positive regulator of GLC7 activity.

Protein Sequence
(Fasta)

MAEIPDETIQ QFMALTNVSH NIAVQYLSEF GDLNEALNSY YASQTDDQKD RREEAHWNRQ 60
QEKALKQEAF STNSSNKAIN TEHVGGLCPK PGSSQGSNEY LKRKGSTSPE PTKGSSRSGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAA TACCTGATGA AACCATCCAG CAGTTCATGG CATTGACCAA TGTGTCGCAT 60
AACATAGCCG TTCAATATCT CTCTGAATTT GGAGATTTAA ATGAAGCACT AAATTCCTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR012989--SEP_domain
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS51399--SEP
PS50033--UBX

Pfam

PF08059--SEP
PF00789--UBX

SMART

SM00553--SEP
SM00166--UBX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019888--F:protein phosphatase regulator activity
GO:0043130--F:ubiquitin binding
GO:0030437--P:ascospore formation
GO:0000045--P:autophagosome assembly
GO:0005977--P:glycogen metabolic process
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0031468--P:nuclear envelope reassembly
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0031134--P:sister chromatid biorientation
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YBL058W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000550	Aegilops tauschii	30.55	9.00e-20	88.20
IUUC-Aml-001919	Ailuropoda melanoleuca	31.37	4.00e-31	126.00
IUUC-Atr-002543	Amborella trichopoda	29.53	1.00e-24	104.00
IUUC-Apl-003388	Anas platyrhynchos	32.56	6.00e-35	139.00
IUUC-Aca-005210	Anolis carolinensis	30.79	8.00e-33	132.00
IUUC-Aly-005499	Arabidopsis lyrata	27.21	7.00e-20	89.00
IUUC-Ath-007064	Arabidopsis thaliana	29.93	6.00e-23	99.40
IUUC-Ago-007933	Ashbya gossypii	57.98	3.00e-85	306.00
IUUC-Acl-008176	Aspergillus clavatus	37.94	4.00e-39	153.00
IUUC-Afl-008553	Aspergillus flavus	33.57	7.00e-28	115.00
IUUC-Afu-008919	Aspergillus fumigatus	35.38	1.00e-35	141.00
IUUC-Ani-009398	Aspergillus nidulans	37.77	3.00e-37	147.00
IUUC-Ang-009594	Aspergillus niger	34.88	1.00e-33	135.00
IUUC-Aor-010016	Aspergillus oryzae	33.69	4.00e-28	116.00
IUUC-Ate-010455	Aspergillus terreus	35.71	3.00e-33	133.00
IUUC-Ame-011089	Astyanax mexicanus	31.25	3.00e-29	120.00
IUUC-Bgr-012256	Blumeria graminis	28.47	8.00e-31	125.00
IUUC-Bta-012898	Bos taurus	31.58	1.00e-31	128.00
IUUC-Bdi-014746	Brachypodium distachyon	29.82	3.00e-25	107.00
IUUC-Bol-016465	Brassica oleracea	28.98	5.00e-21	92.80
IUUC-Bra-017637	Brassica rapa	29.24	1.00e-22	99.00
IUUC-Cel-018169	Caenorhabditis elegans	29.49	3.00e-17	80.10
IUUC-Cja-018993	Callithrix jacchus	31.25	2.00e-31	127.00
IUUC-Cfa-020958	Canis familiaris	31.25	1.00e-31	128.00
IUUC-Cpo-021417	Cavia porcellus	30.56	1.00e-32	131.00
IUUC-Csa-023244	Chlorocebus sabaeus	30.79	3.00e-32	130.00
IUUC-Cho-024683	Choloepus hoffmanni	33.16	6.00e-12	62.40
IUUC-Cin-025686	Ciona intestinalis	32.13	4.00e-29	120.00
IUUC-Csv-025945	Ciona savignyi	29.79	1.00e-27	115.00
IUUC-Cgl-026628	Colletotrichum gloeosporioides	32.16	3.00e-16	77.40
IUUC-Cne-026798	Cryptococcus neoformans	37.75	3.00e-32	130.00
IUUC-Cme-027347	Cyanidioschyzon merolae	28.71	7.00e-22	95.90
IUUC-Dre-028748	Danio rerio	30.43	7.00e-30	122.00
IUUC-Dno-029977	Dasypus novemcinctus	31.70	2.00e-31	127.00
IUUC-Dor-030203	Dipodomys ordii	31.92	2.00e-31	127.00
IUUC-Dse-031256	Dothistroma septosporum	33.44	5.00e-35	139.00
IUUC-Dme-031878	Drosophila melanogaster	29.79	2.00e-20	91.70
IUUC-Ete-032997	Echinops telfairi	31.48	2.00e-31	127.00
IUUC-Eca-034132	Equus caballus	31.15	2.00e-31	127.00
IUUC-Eeu-035097	Erinaceus europaeus	48.48	3.00e-04	37.70
IUUC-Fca-036037	Felis catus	31.27	7.00e-31	125.00
IUUC-Fal-037100	Ficedula albicollis	31.79	4.00e-34	136.00
IUUC-Fox-037690	Fusarium oxysporum	52.94	2.00e-04	36.60
IUUC-Fso-038190	Fusarium solani	29.55	5.00e-25	106.00
IUUC-Gmo-039429	Gadus morhua	30.71	5.00e-28	116.00
IUUC-Ggr-039971	Gaeumannomyces graminis	23.85	2.00e-09	55.10
IUUC-Gga-040864	Gallus gallus	31.56	4.00e-33	133.00
IUUC-Gac-041589	Gasterosteus aculeatus	30.82	2.00e-27	114.00
IUUC-Gma-043511	Glycine max	30.27	2.00e-23	100.00
IUUC-Ggo-044601	Gorilla gorilla	31.25	2.00e-31	127.00
IUUC-Hsa-045773	Homo sapiens	31.13	2.00e-32	130.00
IUUC-Hvu-047203	Hordeum vulgare	28.82	4.00e-19	86.30
IUUC-Itr-047949	Ictidomys tridecemlineatus	32.03	2.00e-31	127.00
IUUC-Kpa-049322	Komagataella pastoris	44.48	3.00e-55	206.00
IUUC-Lch-050161	Latimeria chalumnae	32.00	2.00e-34	137.00
IUUC-Lpe-051122	Leersia perrieri	28.72	3.00e-23	100.00
IUUC-Loc-052555	Lepisosteus oculatus	29.90	2.00e-29	120.00
IUUC-Lma-053319	Leptosphaeria maculans	33.80	8.00e-33	132.00
IUUC-Laf-054237	Loxodonta africana	31.70	3.00e-32	130.00
IUUC-Mcc-055472	Macaca mulatta	31.25	2.00e-31	127.00
IUUC-Meu-056093	Macropus eugenii	31.95	1.00e-18	85.10
IUUC-Mor-057220	Magnaporthe oryzae	33.33	2.00e-31	128.00
IUUC-Mpo-057595	Magnaporthe poae	26.13	8.00e-11	59.30
IUUC-Mtr-057665	Medicago truncatula	31.44	3.00e-25	106.00
IUUC-Mla-059077	Melampsora laricipopulina	30.96	2.00e-32	131.00
IUUC-Mga-059836	Meleagris gallopavo	31.79	1.00e-33	135.00
IUUC-Mvi-060292	Microbotryum violaceum	32.59	4.00e-31	127.00
IUUC-Mmr-060897	Microcebus murinus	30.92	6.00e-31	125.00
IUUC-Mdo-062066	Monodelphis domestica	31.58	8.00e-31	125.00
IUUC-Mmu-063686	Mus musculus	31.70	2.00e-30	124.00
IUUC-Mac-065403	Musa acuminata	28.67	9.00e-24	102.00
IUUC-Mpu-065688	Mustela putorius furo	31.25	1.00e-31	128.00
IUUC-Mlu-067566	Myotis lucifugus	30.69	7.00e-31	125.00
IUUC-Nfi-068609	Neosartorya fischeri	35.38	2.00e-35	140.00
IUUC-Ncr-068786	Neurospora crassa	33.68	6.00e-30	122.00
IUUC-Nle-069169	Nomascus leucogenys	31.02	3.00e-32	130.00
IUUC-Opr-070979	Ochotona princeps	33.55	3.00e-31	127.00
IUUC-Ont-071803	Oreochromis niloticus	31.67	4.00e-31	126.00
IUUC-Oan-073007	Ornithorhynchus anatinus	27.94	5.00e-27	112.00
IUUC-Ocu-074276	Oryctolagus cuniculus	31.13	3.00e-32	130.00
IUUC-Oba-075011	Oryza barthii	32.87	8.00e-24	102.00
IUUC-Obr-076164	Oryza brachyantha	32.06	3.00e-15	73.20
IUUC-Ogl-077805	Oryza glaberrima	32.87	8.00e-24	102.00
IUUC-Ogu-078942	Oryza glumaepatula	32.86	1.00e-23	102.00
IUUC-Oin-079497	Oryza indica	31.80	6.00e-20	89.40
IUUC-Olo-080254	Oryza longistaminata	34.39	1.00e-17	82.00
IUUC-Ome-081766	Oryza meridionalis	27.56	3.00e-20	92.00
IUUC-Oni-082258	Oryza nivara	32.87	8.00e-24	102.00
IUUC-Opu-083365	Oryza punctata	28.27	4.00e-21	93.60
IUUC-Oru-084748	Oryza rufipogon	32.86	1.00e-23	102.00
IUUC-Osa-085359	Oryza sativa	32.87	8.00e-24	102.00
IUUC-Ola-086761	Oryzias latipes	32.26	8.00e-29	119.00
IUUC-Olu-087598	Ostreococcus lucimarinus	29.59	3.00e-21	93.60
IUUC-Oga-088533	Otolemur garnettii	31.13	2.00e-32	130.00
IUUC-Oar-089450	Ovis aries	31.58	1.00e-31	128.00
IUUC-Ptr-090926	Pan troglodytes	31.13	2.00e-32	130.00
IUUC-Pan-092100	Papio anubis	31.13	2.00e-32	131.00
IUUC-Psi-093446	Pelodiscus sinensis	30.62	3.00e-30	123.00
IUUC-Pma-094475	Petromyzon marinus	29.14	1.00e-28	117.00
IUUC-Pno-094769	Phaeosphaeria nodorum	34.60	7.00e-37	145.00
IUUC-Ppa-095833	Physcomitrella patens	30.67	1.00e-24	105.00
IUUC-Pfo-096193	Poecilia formosa	32.03	2.00e-30	124.00
IUUC-Pab-097971	Pongo abelii	31.13	2.00e-32	130.00
IUUC-Pop-099170	Populus trichocarpa	31.46	1.00e-26	111.00
IUUC-Pca-100390	Procavia capensis	30.65	1.00e-16	77.80
IUUC-Ppe-101417	Prunus persica	30.58	4.00e-25	107.00
IUUC-Pva-102504	Pteropus vampyrus	31.37	1.00e-30	125.00
IUUC-Pgr-103447	Puccinia graminis	31.86	2.00e-30	125.00
IUUC-Ptt-103729	Puccinia triticina	31.65	1.00e-33	135.00
IUUC-Pte-104083	Pyrenophora teres	35.47	1.00e-36	145.00
IUUC-Pyt-104504	Pyrenophora triticirepentis	34.46	9.00e-29	119.00
IUUC-Rno-105448	Rattus norvegicus	31.58	3.00e-31	127.00
IUUC-Sha-106777	Sarcophilus harrisii	26.27	6.00e-06	42.00
IUUC-Sja-107717	Schizosaccharomyces japonicus	37.24	1.00e-38	151.00
IUUC-Spo-108358	Schizosaccharomyces pombe	35.38	2.00e-36	144.00
IUUC-Smo-109535	Selaginella moellendorffii	31.48	1.00e-22	98.20
IUUC-Sit-110328	Setaria italica	31.49	2.00e-24	104.00
IUUC-Sly-111203	Solanum lycopersicum	31.67	5.00e-25	105.00
IUUC-Stu-112828	Solanum tuberosum	30.11	7.00e-21	92.00
IUUC-Sar-113445	Sorex araneus	31.12	3.00e-14	70.50
IUUC-Sbi-114513	Sorghum bicolor	31.45	6.00e-26	109.00
IUUC-Sre-115176	Sporisorium reilianum	31.90	1.00e-32	132.00
IUUC-Ssc-116008	Sus scrofa	31.58	9.00e-32	128.00
IUUC-Tgu-117238	Taeniopygia guttata	31.91	3.00e-34	136.00
IUUC-Tru-118521	Takifugu rubripes	30.90	2.00e-33	134.00
IUUC-Tsy-119015	Tarsius syrichta	29.91	3.00e-25	107.00
IUUC-Tni-119705	Tetraodon nigroviridis	30.00	1.00e-32	131.00
IUUC-Tca-121370	Theobroma cacao	26.04	9.00e-17	79.30
IUUC-Tre-121941	Trichoderma reesei	29.03	2.00e-26	110.00
IUUC-Tvi-122602	Trichoderma virens	31.49	1.00e-23	102.00
IUUC-Tae-123686	Triticum aestivum	30.28	1.00e-22	98.20
IUUC-Tur-126464	Triticum urartu	28.50	1.00e-17	81.30
IUUC-Tme-127193	Tuber melanosporum	37.80	5.00e-43	166.00
IUUC-Tbe-127716	Tupaia belangeri	32.57	4.00e-30	122.00
IUUC-Ttr-128262	Tursiops truncatus	30.26	3.00e-30	123.00
IUUC-Uma-129600	Ustilago maydis	31.63	6.00e-31	126.00
IUUC-Vda-129743	Verticillium dahliae	29.47	2.00e-24	104.00
IUUC-Vpa-130155	Vicugna pacos	28.72	2.00e-25	107.00
IUUC-Vvi-131338	Vitis vinifera	30.56	2.00e-22	97.40
IUUC-Xtr-132381	Xenopus tropicalis	30.69	1.00e-17	80.90
IUUC-Xma-133944	Xiphophorus maculatus	32.03	2.00e-30	124.00
IUUC-Yli-134604	Yarrowia lipolytica	37.09	1.00e-32	132.00
IUUC-Zma-135541	Zea mays	29.93	5.00e-22	96.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence