iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106848

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01217831

Gene Name

UBE2K

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000007839.1	ENSSHAT00000009126.1	ENSSHAP00000009051.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.70e-44	151.1	21	146
UBD/Alpha-Helix/UBA	5.10e-11	42.5	161	199

Active Site

Position(s)	Description	Evidence
92	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 11   kdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsv 98
           k+++++i++++vde ++te++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+ilk  ++W +a+++
   Q: 21   KTSKNQIKVDLVDE-NFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDILK--DQWAAAMTL 106
           456789********.9***************************************************99********9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 107  RTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 146
           *************************************986 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+e+l++MGFdr++++ aL + ++++e A+e+Ll+
   Q: 161  EYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLS 199
           6789*********************************97 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

WAELLFNSPS PNFLNILKNF KTSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 60
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGCTGAGC TCCTCTTCAA CTCACCCTCA CCCAACTTCT TAAACATACT AAAGAAATAA 60
ATCACTTTTT ATTTGGCATA AAATTTATGT TTTTGAAAAG GGTTGTAAAA CTTCATTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0032433--C:filopodium tip
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0035458--P:cellular response to interferon-beta
GO:0010994--P:free ubiquitin chain polymerization
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0070936--P:protein K48-linked ubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004122	Anas platyrhynchos	99.43	1.00e-94	338.00
IUUC-Aca-004565	Anolis carolinensis	99.46	1.00e-99	355.00
IUUC-Cho-024276	Choloepus hoffmanni	96.60	3.00e-73	266.00
IUUC-Dno-029169	Dasypus novemcinctus	96.28	4.00e-98	350.00
IUUC-Eeu-035103	Erinaceus europaeus	73.44	6.00e-49	185.00
IUUC-Lch-050588	Latimeria chalumnae	68.72	8.00e-76	276.00
IUUC-Laf-053688	Loxodonta africana	100.00	2.00e-97	347.00
IUUC-Mga-059254	Meleagris gallopavo	99.44	2.00e-97	347.00
IUUC-Mlu-067682	Myotis lucifugus	100.00	2.00e-99	353.00
IUUC-Nle-069712	Nomascus leucogenys	99.45	3.00e-98	350.00
IUUC-Oan-073058	Ornithorhynchus anatinus	100.00	3.00e-78	283.00
IUUC-Olu-087846	Ostreococcus lucimarinus	48.86	6.00e-41	159.00
IUUC-Oga-088897	Otolemur garnettii	98.38	5.00e-98	349.00
IUUC-Oar-089673	Ovis aries	97.85	2.00e-99	354.00
IUUC-Pan-092034	Papio anubis	98.90	9.00e-98	348.00
IUUC-Sar-113285	Sorex araneus	84.36	7.00e-76	275.00
IUUC-Tgu-117427	Taeniopygia guttata	100.00	1.00e-97	348.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence