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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046342
UUCD1 version UUC-HoS-00422
Ensembl Protein ID ENSP00000264350.3
UniProt Accession Q9UII4; B2RTQ1; Q69G20; HERC5_HUMAN
Genbank Protein ID BAA88519.1; AAR00320.1; AAI40717.1
Protein Name E3 ISG15--protein ligase HERC5; Cyclin-E-binding protein 1; HECT domain and RCC1-like domain-containing protein 5
Genbank Nucleotide ID AB027289; AY337518; AC083829
Gene Name HERC5; CEB1; CEBP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138646.8 ENST00000264350.7 ENSP00000264350.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 15331633; 20175895; 18535780
Classification
Family E-value Score Start End
E3 activity/HECT 1.30e-90 305.9 703 1024
Active Site
Position(s) Description Evidence
994 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++dl+k+l+v+f+gE g dlgGv++ef+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G+l+g++l++ ++ +lp
   Q: 703  NEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCNVANLP 787
           689********************************************************9....567888.99***************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           ++ +++k+ll++  sledl+e+ p+l k+l+ +++ + ++ e       f ++ ++  ++++++L+p+G++i V+++Nk++Yv+++++y+
   Q: 788  FPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFE-----EVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYI 872
           **********************************87544444.....455555667779999**************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgs 271
           +++++k  +e+fr+Gf++++++++++lF++eel+ +i G++++d+++++k+++y+ gy++++p+i +Fw+++++++ ee+k+fL F+Tg+
   Q: 873  FNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGT 962
           ****************************************************************************************** PP
   S: 272  srlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +rl ++ ++++k   f+++++ ++++ +++ TCf++L LP+Ys++e+++e L+ Ai++++gF+
   Q: 963  DRLQMKDLNNMK-ITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGFG 1024
           ************.77999999****************************************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
 Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
Protein Sequence
(Fasta)
MERRSRRKSR RNGRSTAGKA AATQPAKSPG AQLWLFPSAA GLHRALLRRV EVTRQLCCSP 60
GRLAVLERGG AGVQVHQLLA GSGGARTPKC IKLGKNMKIH SVDQGAEHML ILSSDGKPFE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046342|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCAGTAGCTG AGGCTGCGGT TCCCCGACGC CACGCAGCTG CGCGCAGCTG GTTCCCGCTC 60
TGCAGCGCAA CGCCTGAGGC AGTGGGCGCG CTCAGTCCCG GGACCAGGCG TTCTCTCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046342|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0051--Antiviral defense
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
Pfam

PF00632--HECT
PF00415--RCC1
PRINTS

PR00633--RCCNDNSATION
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0032020--P:ISG15-protein conjugation
GO:0032480--P:negative regulation of type I interferon production
GO:0000209--P:protein polyubiquitination
GO:0000079--P:regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0050688--P:regulation of defense response to virus
KEGG hsa:51191
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001676 Ailuropoda melanoleuca 77.14 0.00e+00 1596.00
IUUC-Bta-012422 Bos taurus 68.78 0.00e+00 1283.00
IUUC-Cja-018751 Callithrix jacchus 90.78 0.00e+00 1896.00
IUUC-Cfa-020247 Canis familiaris 76.58 0.00e+00 1504.00
IUUC-Csa-023204 Chlorocebus sabaeus 95.15 0.00e+00 1723.00
IUUC-Cho-025101 Choloepus hoffmanni 62.78 4.00e-178 618.00
IUUC-Dno-029795 Dasypus novemcinctus 70.26 0.00e+00 1145.00
IUUC-Dor-030862 Dipodomys ordii 66.16 0.00e+00 1284.00
IUUC-Ete-032585 Echinops telfairi 59.86 0.00e+00 842.00
IUUC-Eca-034358 Equus caballus 76.01 0.00e+00 1489.00
IUUC-Eeu-035282 Erinaceus europaeus 65.58 0.00e+00 733.00
IUUC-Fca-036505 Felis catus 77.60 0.00e+00 1569.00
IUUC-Ggo-045445 Gorilla gorilla 95.44 0.00e+00 1865.00
IUUC-Itr-049004 Ictidomys tridecemlineatus 70.67 0.00e+00 1426.00
IUUC-Laf-053921 Loxodonta africana 72.19 0.00e+00 1469.00
IUUC-Mcc-054850 Macaca mulatta 95.26 0.00e+00 1729.00
IUUC-Mmr-060783 Microcebus murinus 66.92 0.00e+00 1211.00
IUUC-Mpu-066123 Mustela putorius furo 76.71 0.00e+00 1581.00
IUUC-Mlu-067914 Myotis lucifugus 76.07 0.00e+00 1420.00
IUUC-Nle-069986 Nomascus leucogenys 96.98 0.00e+00 1954.00
IUUC-Opr-070513 Ochotona princeps 69.80 0.00e+00 1052.00
IUUC-Ocu-074305 Oryctolagus cuniculus 72.52 0.00e+00 1386.00
IUUC-Oar-089456 Ovis aries 76.61 0.00e+00 1518.00
IUUC-Ptr-091216 Pan troglodytes 89.00 0.00e+00 1743.00
IUUC-Pan-091706 Papio anubis 93.87 0.00e+00 1858.00
IUUC-Pab-097883 Pongo abelii 96.65 0.00e+00 795.00
IUUC-Pca-100320 Procavia capensis 66.20 0.00e+00 1348.00
IUUC-Pva-102646 Pteropus vampyrus 77.98 0.00e+00 1580.00
IUUC-Sar-113605 Sorex araneus 75.38 2.00e-150 526.00
IUUC-Tsy-119240 Tarsius syrichta 66.38 0.00e+00 1239.00
IUUC-Tbe-127787 Tupaia belangeri 71.09 0.00e+00 1352.00
IUUC-Ttr-128191 Tursiops truncatus 74.70 0.00e+00 1490.00
Created Date 25-Jun-2017

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