iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053921

UUCD1 version

UUC-LoA-00890

Ensembl Protein ID

ENSLAFP00000026230.1

UniProt Accession

G3UEH2; G3UEH2_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011856.3	ENSLAFT00000034218.1	ENSLAFP00000026230.1
ENSLAFG00000011856.3	ENSLAFT00000037128.1	ENSLAFP00000028379.1
ENSLAFG00000011856.3	ENSLAFT00000011857.3	ENSLAFP00000009908.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.50e-83	279.5	710	1031

Active Site

Position(s)	Description	Evidence
1001	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           +dl+k+l+v+f+gE + + gGv +ef++++++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G+l+g++l++  + +
   Q: 710  EDLRKELWVSFSGEINYGFGGVRLEFFHCIFEEMTRPEYGMFMYPEEASYMWFPVRPKF----EEKRYF-FFGVLCGLSLFNFSVAN 791
           699*******************************************************9....566777.99*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           +p++ +++k+ll++  sledl+e+ p l k l+ +++ + +d  e  + ++f+       + +e eL+p+G++i+V ++Nk+eYv++
   Q: 792  IPFPLALFKKLLDQTPSLEDLKELSPVLGKCLQTLLDDEGKDFGEV-FYIRFD----AHWDKNEAELIPNGSDIMVDQTNKREYVSK 873
           ************************************9877677665.666665....566789999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v+y+++ ++k  +e+f++Gf++v+++el+++F++eel+ +i G++++d+e+++k++ y++gy++++p+i++Fw++l++++ ee+k+
   Q: 874  YVDYIFNVSVKGVYEEFQRGFYSVCDKELIEIFHPEELKDVIIGNTDYDWETFEKNACYEEGYSSSHPTIEMFWKALHKLTLEEKKK 960
           *************************************************************************************** PP
   S: 264  fLqF.vTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           fL   + g +rl +gG++++k   f+++ + ++++ ++++TC + + LP+Ys++e ++e L +Ai++ +gF+
   Q: 961  FLVLpLLGXDRLQMGGLKNMK-ITFCCPGNLNEKDPIRAQTCLSIIYLPKYSTMERVEEALHVAIDSHRGFG 1031
           **97589**************.77999999**************************************9996 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MKRMPRRRSR GPERPAPKPK PASRPGARSS AAFSDPRGAQ LWLFPSSAGL SQALSGRCKK 60
TRQICCTQDR LAVLEHGGAR VEVHQLPVGS HSAGKPKYMT LERKMMIHSI DQGAEHMLIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGCGGA TGCCACGAAG GAGGTCGCGG GGCCCCGAGC GCCCAGCGCC CAAGCCGAAA 60
CCCGCATCAC GCCCCGGCGC GCGCAGCTCC GCAGCCTTTT CGGACCCGAG GGGCGCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	75.93	0.00e+00	1565.00
IUUC-Bta-012422	Bos taurus	69.41	0.00e+00	1300.00
IUUC-Cja-018751	Callithrix jacchus	70.48	0.00e+00	1437.00
IUUC-Cfa-020247	Canis familiaris	77.55	0.00e+00	1496.00
IUUC-Csa-023204	Chlorocebus sabaeus	73.71	0.00e+00	1327.00
IUUC-Cho-025101	Choloepus hoffmanni	63.86	1.00e-179	624.00
IUUC-Dno-029795	Dasypus novemcinctus	72.75	0.00e+00	1169.00
IUUC-Dor-030862	Dipodomys ordii	62.94	0.00e+00	1204.00
IUUC-Ete-032585	Echinops telfairi	61.97	0.00e+00	850.00
IUUC-Eca-034358	Equus caballus	74.46	0.00e+00	1451.00
IUUC-Eeu-035282	Erinaceus europaeus	64.38	0.00e+00	711.00
IUUC-Fca-036505	Felis catus	76.02	0.00e+00	1534.00
IUUC-Ggo-045445	Gorilla gorilla	70.48	0.00e+00	1368.00
IUUC-Hsa-046342	Homo sapiens	71.77	0.00e+00	1427.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	67.60	0.00e+00	1350.00
IUUC-Mcc-054850	Macaca mulatta	73.71	0.00e+00	1334.00
IUUC-Mmr-060783	Microcebus murinus	62.43	0.00e+00	1114.00
IUUC-Mpu-066123	Mustela putorius furo	74.20	0.00e+00	1529.00
IUUC-Mlu-067914	Myotis lucifugus	73.82	0.00e+00	1363.00
IUUC-Nle-069986	Nomascus leucogenys	72.51	0.00e+00	1449.00
IUUC-Opr-070513	Ochotona princeps	65.15	0.00e+00	979.00
IUUC-Ocu-074305	Oryctolagus cuniculus	68.62	0.00e+00	1314.00
IUUC-Oga-088858	Otolemur garnettii	63.74	0.00e+00	1194.00
IUUC-Oar-089456	Ovis aries	75.60	0.00e+00	1465.00
IUUC-Ptr-091216	Pan troglodytes	73.36	0.00e+00	1271.00
IUUC-Pan-091706	Papio anubis	72.29	0.00e+00	1388.00
IUUC-Pca-100320	Procavia capensis	71.50	0.00e+00	1439.00
IUUC-Pva-102646	Pteropus vampyrus	76.28	0.00e+00	1545.00
IUUC-Sar-113605	Sorex araneus	76.35	4.00e-154	538.00
IUUC-Tsy-119240	Tarsius syrichta	61.50	0.00e+00	1147.00
IUUC-Tbe-127787	Tupaia belangeri	68.77	0.00e+00	1291.00
IUUC-Ttr-128191	Tursiops truncatus	72.72	0.00e+00	1436.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence