iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054850

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

JSUE03033962

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000010316.3	ENSMMUT00000014431.3	ENSMMUP00000013519.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-89	301.4	606	927

Active Site

Position(s)	Description	Evidence
897	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl+k+l+v+f+gE g dl Gv+ref+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G l+g++l++ ++ +l
   Q: 606  NEDLRKELWVSFSGEIGYDLVGVKREFFYCLFEEMIQPEYGMFMYPEGASCMWFPVRPKF----EKKRYF-FFGLLCGLSLFNCNVANL 689
           689********************************************************9....567888.99**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           p++ +++k+ll++  sledl+e+ p+l k+l+ +++ + ++ e       f ++ ++  ++++++L+p+G++i V+++Nk++Yv+++++
   Q: 690  PFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFE-----EVFYIHFNVHWDRNDTNLIPNGSSIIVNQTNKRDYVSKYID 773
           ***********************************87544444.....455555667779999************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y++++++k  +e+fr+Gf++++++++++lF++eel+ +i G +++d+++++k+++y+ gy++++p+i +Fw+++++++ ee+k+fL F+
   Q: 774  YIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGHTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFL 862
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg++rl  + ++++k   f+++++ ++++  ++ TCf++L LP+Ys++e+++e L++Ai++++gF+
   Q: 863  TGTDRLQTKDLKNMK-ITFCCPESWNERDPMRALTCFSVLFLPKYSTMETVEEALQVAINNNRGFG 927
           ***************.7799999999**************************************96 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MKIHSVDQGA DHMLILSSDG KPFEYDYSMK HLRSESILQE KKIIQITCGD YHSLALSKGG 60
ELFAWGQNLH GQLGVGRKFP STTTPQIVEH LAGVPLAQIS AGEAHSMALS MSGNIYSWGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGGGCAG AGGTGACGCG CCAAATCTGC TGTTCGCCGC GGCGCCTAGC GGTCTTGGAG 60
CGCGGCGGGG CGGGCGTCCA GGTTCACCAG GTGCTCGCGG GGAGCGGCGG CGCCCGAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	76.96	0.00e+00	1493.00
IUUC-Cja-018751	Callithrix jacchus	91.59	0.00e+00	1748.00
IUUC-Cfa-020247	Canis familiaris	77.96	0.00e+00	1495.00
IUUC-Csa-023204	Chlorocebus sabaeus	99.03	0.00e+00	1804.00
IUUC-Cho-025101	Choloepus hoffmanni	62.78	3.00e-177	615.00
IUUC-Dno-029795	Dasypus novemcinctus	71.05	0.00e+00	1053.00
IUUC-Dor-030862	Dipodomys ordii	66.67	0.00e+00	1207.00
IUUC-Ete-032585	Echinops telfairi	60.63	0.00e+00	839.00
IUUC-Eca-034358	Equus caballus	76.59	0.00e+00	1443.00
IUUC-Eeu-035282	Erinaceus europaeus	64.73	0.00e+00	724.00
IUUC-Fca-036505	Felis catus	77.53	0.00e+00	1493.00
IUUC-Ggo-045445	Gorilla gorilla	91.70	0.00e+00	1656.00
IUUC-Hsa-046342	Homo sapiens	95.26	0.00e+00	1745.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	70.49	0.00e+00	1324.00
IUUC-Laf-053921	Loxodonta africana	73.71	0.00e+00	1398.00
IUUC-Mmr-060783	Microcebus murinus	66.77	0.00e+00	1197.00
IUUC-Mpu-066123	Mustela putorius furo	76.10	0.00e+00	1464.00
IUUC-Mlu-067914	Myotis lucifugus	76.10	0.00e+00	1412.00
IUUC-Nle-069986	Nomascus leucogenys	95.80	0.00e+00	1792.00
IUUC-Opr-070513	Ochotona princeps	69.18	0.00e+00	952.00
IUUC-Ocu-074305	Oryctolagus cuniculus	72.47	0.00e+00	1375.00
IUUC-Oga-088858	Otolemur garnettii	66.38	0.00e+00	1171.00
IUUC-Oar-089456	Ovis aries	76.72	0.00e+00	1406.00
IUUC-Ptr-091216	Pan troglodytes	95.06	0.00e+00	1654.00
IUUC-Pan-091706	Papio anubis	98.49	0.00e+00	1791.00
IUUC-Pca-100320	Procavia capensis	67.13	0.00e+00	1279.00
IUUC-Pva-102646	Pteropus vampyrus	78.32	0.00e+00	1473.00
IUUC-Sar-113605	Sorex araneus	75.30	2.00e-150	526.00
IUUC-Tsy-119240	Tarsius syrichta	67.10	0.00e+00	1243.00
IUUC-Tbe-127787	Tupaia belangeri	70.98	0.00e+00	1339.00
IUUC-Ttr-128191	Tursiops truncatus	74.89	0.00e+00	1404.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence