iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cja-019577

UUCD1 version

UUC-CaJ-00790

Ensembl Protein ID

ENSCJAP00000023381.2

UniProt Accession

F7HZC2; F7HZC2_CALJA

Genbank Protein ID

JAB08774.1; JAB13666.1

Protein Name

E3 ubiquitin-protein ligase AMFR

Genbank Nucleotide ID

ACFV01100244; GAMS01009470

Gene Name

AMFR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000012741.2	ENSCJAT00000024737.2	ENSCJAP00000023381.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.10e-08	36.4	341	379
UBD/Alpha-Helix/CUE	4.80e-11	43.3	456	497

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 341  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 379
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 456  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 497
           5889*********************.***************95 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MPLLFLERFP WPSLRTYTGL SGLALLGTIV SAYRALSQPE AGPSEPAPLT ASLQPEQPVP 60
ARSSAGGPRA RDVAQYLLSD SLFVWVLVNT ACCVLMLVAK LIQCIVFGPL RVSERQHLKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGCGGGG CGGAGCGGCG CCAGCAGCCA GCAGCTACCC GGCCCGGCTC CGGCGCGGCG 60
GCGGCGGCGG CGGCGGCGGC TGCGGCAGCG ACGCCAGAGC TCGTGGGCGC TGTTCGCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0016874--F:ligase activity
GO:0004872--F:receptor activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

cjc:100392285

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	93.36	0.00e+00	1021.00
IUUC-Apl-003404	Anas platyrhynchos	88.08	0.00e+00	949.00
IUUC-Aca-004559	Anolis carolinensis	85.66	0.00e+00	876.00
IUUC-Ame-011640	Astyanax mexicanus	73.37	0.00e+00	844.00
IUUC-Bta-012980	Bos taurus	87.62	0.00e+00	1085.00
IUUC-Cel-018598	Caenorhabditis elegans	25.29	4.00e-35	142.00
IUUC-Cfa-020793	Canis familiaris	94.46	0.00e+00	1033.00
IUUC-Cpo-022387	Cavia porcellus	94.56	0.00e+00	1178.00
IUUC-Csa-023168	Chlorocebus sabaeus	97.67	0.00e+00	1246.00
IUUC-Cho-024433	Choloepus hoffmanni	96.22	0.00e+00	859.00
IUUC-Cin-025215	Ciona intestinalis	44.12	2.00e-146	512.00
IUUC-Csv-026133	Ciona savignyi	47.81	2.00e-132	465.00
IUUC-Dre-027594	Danio rerio	68.72	0.00e+00	791.00
IUUC-Dno-029407	Dasypus novemcinctus	96.42	0.00e+00	1035.00
IUUC-Dor-030961	Dipodomys ordii	96.06	0.00e+00	1054.00
IUUC-Ete-032962	Echinops telfairi	86.74	0.00e+00	874.00
IUUC-Eca-033683	Equus caballus	88.98	0.00e+00	1083.00
IUUC-Eeu-034515	Erinaceus europaeus	100.00	2.00e-80	293.00
IUUC-Fca-035398	Felis catus	95.70	0.00e+00	996.00
IUUC-Fal-036758	Ficedula albicollis	81.40	0.00e+00	887.00
IUUC-Gmo-039014	Gadus morhua	69.62	0.00e+00	775.00
IUUC-Gga-040575	Gallus gallus	84.76	0.00e+00	1034.00
IUUC-Gac-041414	Gasterosteus aculeatus	68.80	0.00e+00	762.00
IUUC-Hsa-046272	Homo sapiens	97.51	0.00e+00	1208.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	95.37	0.00e+00	1028.00
IUUC-Lch-050491	Latimeria chalumnae	75.33	0.00e+00	867.00
IUUC-Loc-052758	Lepisosteus oculatus	76.10	0.00e+00	858.00
IUUC-Laf-053452	Loxodonta africana	96.25	0.00e+00	1032.00
IUUC-Mcc-055820	Macaca mulatta	98.54	0.00e+00	1066.00
IUUC-Meu-056726	Macropus eugenii	86.17	0.00e+00	870.00
IUUC-Mga-059937	Meleagris gallopavo	86.47	0.00e+00	955.00
IUUC-Mmr-060730	Microcebus murinus	93.31	0.00e+00	1146.00
IUUC-Mdo-062771	Monodelphis domestica	89.22	0.00e+00	1095.00
IUUC-Mmu-064219	Mus musculus	94.38	0.00e+00	1193.00
IUUC-Mpu-066796	Mustela putorius furo	95.26	0.00e+00	1033.00
IUUC-Mlu-068189	Myotis lucifugus	93.71	0.00e+00	1025.00
IUUC-Nle-069239	Nomascus leucogenys	97.42	0.00e+00	1192.00
IUUC-Opr-070702	Ochotona princeps	90.94	2.00e-147	515.00
IUUC-Ont-072033	Oreochromis niloticus	71.12	0.00e+00	823.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.33	0.00e+00	871.00
IUUC-Ocu-074145	Oryctolagus cuniculus	93.00	0.00e+00	1170.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	1.00e-11	62.80
IUUC-Ola-087152	Oryzias latipes	68.89	0.00e+00	797.00
IUUC-Oga-088486	Otolemur garnettii	96.80	0.00e+00	1044.00
IUUC-Oar-089310	Ovis aries	94.82	0.00e+00	1054.00
IUUC-Ptr-090649	Pan troglodytes	98.39	0.00e+00	1085.00
IUUC-Pan-091692	Papio anubis	93.47	0.00e+00	1144.00
IUUC-Psi-093064	Pelodiscus sinensis	94.97	0.00e+00	780.00
IUUC-Pma-094763	Petromyzon marinus	77.46	1.00e-97	348.00
IUUC-Ppa-095969	Physcomitrella patens	29.91	4.00e-36	145.00
IUUC-Pfo-096810	Poecilia formosa	71.03	0.00e+00	811.00
IUUC-Pab-097859	Pongo abelii	98.54	0.00e+00	1067.00
IUUC-Pop-099576	Populus trichocarpa	27.06	1.00e-28	120.00
IUUC-Pca-100344	Procavia capensis	92.40	0.00e+00	1108.00
IUUC-Pva-103114	Pteropus vampyrus	68.47	0.00e+00	749.00
IUUC-Rno-105880	Rattus norvegicus	92.28	0.00e+00	1142.00
IUUC-Sha-107015	Sarcophilus harrisii	93.92	0.00e+00	1013.00
IUUC-Smo-109664	Selaginella moellendorffii	31.21	2.00e-33	136.00
IUUC-Sar-113397	Sorex araneus	98.92	0.00e+00	771.00
IUUC-Ssc-115988	Sus scrofa	91.67	4.00e-146	510.00
IUUC-Tgu-116717	Taeniopygia guttata	89.36	0.00e+00	953.00
IUUC-Tru-117805	Takifugu rubripes	68.83	0.00e+00	823.00
IUUC-Tsy-119442	Tarsius syrichta	90.86	0.00e+00	972.00
IUUC-Tni-119777	Tetraodon nigroviridis	72.92	2.00e-172	598.00
IUUC-Tbe-127322	Tupaia belangeri	68.98	4.00e-116	411.00
IUUC-Ttr-128181	Tursiops truncatus	94.44	0.00e+00	1050.00
IUUC-Vpa-130483	Vicugna pacos	85.71	0.00e+00	667.00
IUUC-Xtr-132614	Xenopus tropicalis	77.27	0.00e+00	805.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence