iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-073776

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02023946

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000007824.2	ENSOCUT00000007826.2	ENSOCUP00000006765.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.00e-42	144.0	388	695

Active Site

Position(s)	Description	Evidence
665	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
            +ev +v+E+   g +++G+++efl+ll+++l+n++  lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++s
   Q: 388  TIEVVYVNEDdpfGREHPGSKQEFLSLLMQHLENSS--LF--EGSLSKNLSLNSQAV-----KENLYYEAGKMLAISLVHGGPSPGFFS 467
           689999**99999***********************..45..777788888888885.....689************************ PP
   S: 94   ksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           k+++++l+  +   e+++ + +++ ++ + +i  +   ++ +  +dl++      ++e++++  + g+++   t ++k++  k+++ y+
   Q: 468  KTLFNCLVYGP---ENTQPILDDVSDFdVAQIIIRI--NTATNMADLNSV-----INECYNYLELIGCQRLATTLSDKYMLAKDILVYH 546
           **********8...*************988888774..344444677765.....888999999************************* PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq... 266
           + +++++ +e+f++G++++  le+++++ e  +++l+ + e+++++ l++   ++ ++ +  +a+  Fw+ + e +++ + ++ L+   
   Q: 547  VIKRVQTPFESFKQGLKTLGVLEKIQAYPEAFCNILCKKPENLSAKILSD--LFTVHTIPGVQAL-GFWNSYlETVEDGKSTTTLEdil 632
           ************************************************99..7888899999998.89998757777777777666666 PP
   S: 267  .FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
            F+Tg+s++P++Gf++ + ++ +++      ++P  n+C n+L LP  +++++++e++ +Ai++t ++e
   Q: 633  lFATGCSSIPPAGFKPAP-SIECLPV-----DFPIGNKCNNCLALPITNTYKEFQENMDFAIRNTLRLE 695
           6****************9.8899999.....********************************987665 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MNENKPDDSR NLACVFCRKN DDCPSKYGEK KTNEKWNLTV HYYCLLMSSG IWQRGKEEEG 60
VYGFLIEDIR KEVNRASKLK CCVCKKTGAS IGCVAPRCKR SYHFPCGLQG ECIFQFTGNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAATTTGA ATCCTGCTGG CCGTTGGATG GGGCTGCTCC AGGTTGGTGT GCGGCGACGC 60
AGCGCGAGAC GGCAAAAGTG ATACGGCCGC TGTGGAACTT CTGCTCTGAG GGCCTCGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

ocu:100350936

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	90.65	0.00e+00	1347.00
IUUC-Apl-003763	Anas platyrhynchos	60.74	0.00e+00	851.00
IUUC-Aca-004328	Anolis carolinensis	60.81	0.00e+00	866.00
IUUC-Ame-011288	Astyanax mexicanus	41.08	3.00e-163	568.00
IUUC-Bta-012496	Bos taurus	86.65	0.00e+00	1283.00
IUUC-Cja-019756	Callithrix jacchus	88.64	0.00e+00	1308.00
IUUC-Cfa-020806	Canis familiaris	89.24	0.00e+00	1330.00
IUUC-Cpo-022519	Cavia porcellus	87.82	0.00e+00	1271.00
IUUC-Csa-023957	Chlorocebus sabaeus	91.22	0.00e+00	1352.00
IUUC-Cho-024375	Choloepus hoffmanni	83.84	0.00e+00	1182.00
IUUC-Cin-025325	Ciona intestinalis	41.89	2.00e-67	248.00
IUUC-Csv-026262	Ciona savignyi	41.69	2.00e-67	249.00
IUUC-Dre-027829	Danio rerio	40.11	1.00e-151	530.00
IUUC-Dno-029362	Dasypus novemcinctus	89.11	0.00e+00	1298.00
IUUC-Dor-030710	Dipodomys ordii	83.12	0.00e+00	1249.00
IUUC-Dme-031692	Drosophila melanogaster	35.29	6.00e-44	172.00
IUUC-Ete-032282	Echinops telfairi	79.83	0.00e+00	1144.00
IUUC-Eca-033963	Equus caballus	89.52	0.00e+00	1336.00
IUUC-Eeu-035029	Erinaceus europaeus	86.10	0.00e+00	1285.00
IUUC-Fca-036229	Felis catus	89.94	0.00e+00	1345.00
IUUC-Fal-037015	Ficedula albicollis	57.80	0.00e+00	854.00
IUUC-Gmo-039715	Gadus morhua	39.35	7.00e-74	270.00
IUUC-Gga-040298	Gallus gallus	58.96	0.00e+00	901.00
IUUC-Gac-041444	Gasterosteus aculeatus	38.46	1.00e-138	486.00
IUUC-Ggo-045456	Gorilla gorilla	90.79	0.00e+00	1342.00
IUUC-Hsa-046297	Homo sapiens	91.08	0.00e+00	1353.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	90.46	0.00e+00	941.00
IUUC-Lch-050287	Latimeria chalumnae	66.67	5.00e-105	375.00
IUUC-Loc-052839	Lepisosteus oculatus	58.16	1.00e-31	127.00
IUUC-Laf-053581	Loxodonta africana	88.01	0.00e+00	1282.00
IUUC-Mcc-055615	Macaca mulatta	91.22	0.00e+00	1355.00
IUUC-Meu-056753	Macropus eugenii	50.57	3.00e-70	259.00
IUUC-Mga-059902	Meleagris gallopavo	58.90	0.00e+00	904.00
IUUC-Mmr-061522	Microcebus murinus	91.93	0.00e+00	1358.00
IUUC-Mdo-063022	Monodelphis domestica	64.82	0.00e+00	884.00
IUUC-Mmu-063609	Mus musculus	76.45	0.00e+00	1163.00
IUUC-Mpu-066656	Mustela putorius furo	90.08	0.00e+00	1347.00
IUUC-Mlu-067011	Myotis lucifugus	88.47	0.00e+00	1293.00
IUUC-Nle-069949	Nomascus leucogenys	90.65	0.00e+00	1344.00
IUUC-Opr-071224	Ochotona princeps	90.23	2.00e-141	496.00
IUUC-Ont-072174	Oreochromis niloticus	38.25	9.00e-137	480.00
IUUC-Oan-072712	Ornithorhynchus anatinus	67.86	0.00e+00	963.00
IUUC-Ola-087247	Oryzias latipes	37.78	4.00e-130	458.00
IUUC-Oga-088094	Otolemur garnettii	87.58	0.00e+00	1221.00
IUUC-Oar-090248	Ovis aries	86.22	0.00e+00	1274.00
IUUC-Ptr-090634	Pan troglodytes	90.93	0.00e+00	1347.00
IUUC-Pan-092876	Papio anubis	91.22	0.00e+00	1350.00
IUUC-Psi-093580	Pelodiscus sinensis	61.69	0.00e+00	880.00
IUUC-Pma-094295	Petromyzon marinus	52.78	2.00e-72	265.00
IUUC-Pfo-096351	Poecilia formosa	38.34	8.00e-143	500.00
IUUC-Pab-097596	Pongo abelii	91.22	0.00e+00	1350.00
IUUC-Pca-100309	Procavia capensis	81.59	0.00e+00	1204.00
IUUC-Pva-102526	Pteropus vampyrus	91.78	0.00e+00	847.00
IUUC-Rno-105432	Rattus norvegicus	81.37	0.00e+00	1210.00
IUUC-Sha-107089	Sarcophilus harrisii	65.23	0.00e+00	992.00
IUUC-Sar-113667	Sorex araneus	66.76	0.00e+00	946.00
IUUC-Ssc-116200	Sus scrofa	89.52	0.00e+00	1329.00
IUUC-Tgu-116467	Taeniopygia guttata	58.24	0.00e+00	848.00
IUUC-Tru-117690	Takifugu rubripes	38.83	6.00e-152	531.00
IUUC-Tsy-119481	Tarsius syrichta	88.00	0.00e+00	918.00
IUUC-Tni-119669	Tetraodon nigroviridis	37.38	1.00e-132	466.00
IUUC-Tbe-127241	Tupaia belangeri	83.21	0.00e+00	1177.00
IUUC-Ttr-129057	Tursiops truncatus	89.05	0.00e+00	1015.00
IUUC-Vpa-130685	Vicugna pacos	87.48	0.00e+00	1263.00
IUUC-Xtr-132555	Xenopus tropicalis	53.61	0.00e+00	748.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence