iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118449

Ensembl Protein ID

ENSTRUP00000003758.1

UniProt Accession

H2RUE1; H2RUE1_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

hck

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000001630.1	ENSTRUT00000003778.1	ENSTRUP00000003758.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.80e-14	52.8	9	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +lydyea +d++Lt+kkGd ++++   e++++W++++ + +g +G +P n+v+k
   Q: 9    VALYDYEAIHDGDLTFKKGDRLKIL---EESGEWWRAKLTSTGDEGYIPCNYVAK 60
           69***********************...99**********************986 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

LAPGEMVAVA LYDYEAIHDG DLTFKKGDRL KILEESGEWW RAKLTSTGDE GYIPCNYVAK 60
DTLETEEWFF KGISRKDAER QLSAPGNVLG SFMIRDSETT KGSYSLSVRD SPTGDTVKHY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGCACCAG GTGAGATGGT TGCCGTGGCG CTGTACGACT ATGAGGCCAT TCATGATGGT 60
GACCTCACCT TCAAGAAGGG GGATCGTCTT AAAATCCTGG AGGAGTGAGT TTCCACAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	80.58	0.00e+00	760.00
IUUC-Apl-003285	Anas platyrhynchos	80.31	0.00e+00	756.00
IUUC-Aca-004724	Anolis carolinensis	81.21	0.00e+00	747.00
IUUC-Ame-011954	Astyanax mexicanus	86.97	0.00e+00	787.00
IUUC-Bta-013060	Bos taurus	81.35	0.00e+00	762.00
IUUC-Cja-019817	Callithrix jacchus	81.12	0.00e+00	759.00
IUUC-Cfa-020511	Canis familiaris	80.36	0.00e+00	760.00
IUUC-Cpo-022538	Cavia porcellus	79.60	0.00e+00	747.00
IUUC-Csa-024143	Chlorocebus sabaeus	81.80	0.00e+00	761.00
IUUC-Dre-028157	Danio rerio	88.94	0.00e+00	833.00
IUUC-Dno-029761	Dasypus novemcinctus	80.13	0.00e+00	759.00
IUUC-Eca-034090	Equus caballus	80.00	0.00e+00	738.00
IUUC-Fca-035937	Felis catus	79.46	0.00e+00	733.00
IUUC-Fal-036624	Ficedula albicollis	79.82	0.00e+00	752.00
IUUC-Gmo-039009	Gadus morhua	83.33	0.00e+00	782.00
IUUC-Gga-040296	Gallus gallus	79.37	0.00e+00	749.00
IUUC-Gac-042362	Gasterosteus aculeatus	88.74	0.00e+00	832.00
IUUC-Ggo-044570	Gorilla gorilla	81.12	0.00e+00	763.00
IUUC-Hsa-046378	Homo sapiens	81.35	0.00e+00	764.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	80.22	0.00e+00	753.00
IUUC-Loc-052904	Lepisosteus oculatus	85.87	0.00e+00	810.00
IUUC-Laf-053654	Loxodonta africana	80.67	0.00e+00	756.00
IUUC-Mcc-055317	Macaca mulatta	82.02	0.00e+00	767.00
IUUC-Mga-060194	Meleagris gallopavo	76.68	0.00e+00	717.00
IUUC-Mmr-061510	Microcebus murinus	80.67	0.00e+00	761.00
IUUC-Mdo-062035	Monodelphis domestica	80.90	0.00e+00	758.00
IUUC-Mmu-064037	Mus musculus	79.33	0.00e+00	751.00
IUUC-Mpu-066874	Mustela putorius furo	80.18	0.00e+00	757.00
IUUC-Mlu-068202	Myotis lucifugus	78.33	0.00e+00	727.00
IUUC-Nle-069222	Nomascus leucogenys	82.02	0.00e+00	766.00
IUUC-Opr-070705	Ochotona princeps	79.33	0.00e+00	748.00
IUUC-Ont-072347	Oreochromis niloticus	90.77	0.00e+00	820.00
IUUC-Ocu-074490	Oryctolagus cuniculus	80.00	0.00e+00	753.00
IUUC-Ola-086521	Oryzias latipes	89.71	0.00e+00	837.00
IUUC-Oga-088153	Otolemur garnettii	82.02	0.00e+00	771.00
IUUC-Oar-090184	Ovis aries	80.13	0.00e+00	751.00
IUUC-Ptr-090505	Pan troglodytes	77.08	0.00e+00	712.00
IUUC-Pan-092260	Papio anubis	82.02	0.00e+00	768.00
IUUC-Pma-094311	Petromyzon marinus	73.20	0.00e+00	691.00
IUUC-Pfo-096566	Poecilia formosa	90.56	0.00e+00	849.00
IUUC-Pva-103021	Pteropus vampyrus	81.57	0.00e+00	761.00
IUUC-Rno-105309	Rattus norvegicus	78.24	0.00e+00	751.00
IUUC-Sha-107099	Sarcophilus harrisii	80.00	0.00e+00	751.00
IUUC-Tgu-116912	Taeniopygia guttata	81.17	0.00e+00	759.00
IUUC-Tbe-128144	Tupaia belangeri	72.58	0.00e+00	662.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence