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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045977
UUCD1 version UUC-HoS-00440
Ensembl Protein ID ENSP00000347834.5
UniProt Accession Q9UKT7; B2RB04; Q9P122; FBXL3_HUMAN
Genbank Protein ID AAF04466.1; AAF37383.1; BAG37051.1; AAH72448.1
Protein Name F-box/LRR-repeat protein 3; F-box and leucine-rich repeat protein 3A; F-box/LRR-repeat protein 3A
Genbank Nucleotide ID AF129532; AF126028; AK314442; BC072448
Gene Name FBXL3; FBL3A; FBXL3A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000005812.10 ENST00000355619.9 ENSP00000347834.5
ENSG00000005812.10 ENST00000417323.1 ENSP00000412183.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 17463251; 20304803
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 6.70e-05 24.6 26 78
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 93   tpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwkt 145
           t +e +++  + +l ++i+++++k+l+  +  +a++vcr+w+++ + + lw+ 
   Q: 26   TTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRC 78
           677888888999999*****************************999***986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).
 Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).
Protein Sequence
(Fasta)
MKRGGRDSDR NSSEEGTAEK SKKLRTTNEH SQTCDWGNLL QDIILQVFKY LPLLDRAHAS 60
QVCRNWNQVF HMPDLWRCFE FELNQPATSY LKATHPELIK QIIKRHSNHL QYVSFKVDSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045977|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGGAAGCGCG CGGCCGCGAG CCCTGGGCGC CATTTTAGAC TCGCTGTTTG TGGCCCAGGT 60
GCAGGAAGCT TACGCGGTGG CAGCCGCTCG CTGAGGTAGT CTCTCGCGGC GCCGGGGATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045977|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:0048511--P:rhythmic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG hsa:26224
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000400 Aegilops tauschii 37.50 1.00e-04 39.70
IUUC-Aml-001552 Ailuropoda melanoleuca 99.30 0.00e+00 854.00
IUUC-Atr-003025 Amborella trichopoda 26.97 7.00e-06 42.40
IUUC-Apl-003485 Anas platyrhynchos 91.22 0.00e+00 780.00
IUUC-Aca-004566 Anolis carolinensis 89.20 0.00e+00 761.00
IUUC-Ath-007384 Arabidopsis thaliana 31.94 3.00e-03 35.80
IUUC-Ame-011238 Astyanax mexicanus 84.88 0.00e+00 714.00
IUUC-Bta-013292 Bos taurus 99.68 8.00e-177 612.00
IUUC-Cja-019876 Callithrix jacchus 99.77 0.00e+00 856.00
IUUC-Cfa-020674 Canis familiaris 99.77 0.00e+00 856.00
IUUC-Cpo-021869 Cavia porcellus 97.43 0.00e+00 795.00
IUUC-Csa-023044 Chlorocebus sabaeus 99.53 0.00e+00 855.00
IUUC-Cho-024975 Choloepus hoffmanni 88.32 0.00e+00 746.00
IUUC-Dre-028017 Danio rerio 86.27 0.00e+00 666.00
IUUC-Dno-028870 Dasypus novemcinctus 98.83 0.00e+00 849.00
IUUC-Dor-030514 Dipodomys ordii 99.30 0.00e+00 853.00
IUUC-Ete-032477 Echinops telfairi 97.61 0.00e+00 728.00
IUUC-Eca-034141 Equus caballus 98.60 0.00e+00 846.00
IUUC-Eeu-035046 Erinaceus europaeus 96.96 0.00e+00 814.00
IUUC-Fca-035829 Felis catus 99.30 0.00e+00 852.00
IUUC-Fal-037609 Ficedula albicollis 91.22 0.00e+00 777.00
IUUC-Gmo-039537 Gadus morhua 81.05 0.00e+00 694.00
IUUC-Gga-040363 Gallus gallus 75.06 0.00e+00 672.00
IUUC-Gac-042440 Gasterosteus aculeatus 82.23 0.00e+00 705.00
IUUC-Gma-042978 Glycine max 29.35 2.00e-05 43.10
IUUC-Ggo-045342 Gorilla gorilla 100.00 0.00e+00 858.00
IUUC-Itr-048500 Ictidomys tridecemlineatus 98.83 0.00e+00 825.00
IUUC-Lch-049981 Latimeria chalumnae 86.54 0.00e+00 739.00
IUUC-Loc-052324 Lepisosteus oculatus 87.73 0.00e+00 731.00
IUUC-Laf-053399 Loxodonta africana 97.90 0.00e+00 842.00
IUUC-Mcc-054813 Macaca mulatta 99.77 0.00e+00 857.00
IUUC-Meu-056017 Macropus eugenii 96.03 0.00e+00 811.00
IUUC-Mga-059960 Meleagris gallopavo 75.75 0.00e+00 674.00
IUUC-Mmr-060711 Microcebus murinus 99.07 0.00e+00 851.00
IUUC-Mdo-062234 Monodelphis domestica 96.51 0.00e+00 830.00
IUUC-Mmu-063181 Mus musculus 97.20 0.00e+00 835.00
IUUC-Mpu-066368 Mustela putorius furo 99.77 0.00e+00 856.00
IUUC-Mlu-067492 Myotis lucifugus 95.56 0.00e+00 812.00
IUUC-Nle-069358 Nomascus leucogenys 99.07 0.00e+00 852.00
IUUC-Opr-070436 Ochotona princeps 96.73 0.00e+00 823.00
IUUC-Ont-072618 Oreochromis niloticus 89.20 0.00e+00 710.00
IUUC-Oan-073386 Ornithorhynchus anatinus 93.52 0.00e+00 796.00
IUUC-Ocu-073808 Oryctolagus cuniculus 97.90 0.00e+00 839.00
IUUC-Oba-075035 Oryza barthii 29.73 2.00e-04 38.90
IUUC-Ola-086567 Oryzias latipes 89.85 0.00e+00 709.00
IUUC-Oga-088421 Otolemur garnettii 98.36 0.00e+00 826.00
IUUC-Oar-090329 Ovis aries 99.03 0.00e+00 818.00
IUUC-Ptr-091390 Pan troglodytes 100.00 0.00e+00 858.00
IUUC-Pan-092155 Papio anubis 98.60 0.00e+00 839.00
IUUC-Psi-093540 Pelodiscus sinensis 92.38 0.00e+00 798.00
IUUC-Ppa-095844 Physcomitrella patens 27.96 2.00e-04 40.00
IUUC-Pfo-096760 Poecilia formosa 89.87 0.00e+00 708.00
IUUC-Pab-097896 Pongo abelii 100.00 0.00e+00 858.00
IUUC-Pca-100935 Procavia capensis 96.94 1.00e-153 535.00
IUUC-Pva-102705 Pteropus vampyrus 99.07 0.00e+00 850.00
IUUC-Pyt-104677 Pyrenophora triticirepentis 23.47 2.60e-02 32.70
IUUC-Rno-104827 Rattus norvegicus 97.43 0.00e+00 834.00
IUUC-Sha-107356 Sarcophilus harrisii 95.35 0.00e+00 823.00
IUUC-Sar-113189 Sorex araneus 97.57 0.00e+00 807.00
IUUC-Sre-114931 Sporisorium reilianum 28.45 1.00e-03 38.50
IUUC-Ssc-115570 Sus scrofa 99.07 0.00e+00 845.00
IUUC-Tgu-116972 Taeniopygia guttata 90.30 0.00e+00 770.00
IUUC-Tru-117842 Takifugu rubripes 86.96 0.00e+00 711.00
IUUC-Tsy-119232 Tarsius syrichta 99.30 0.00e+00 850.00
IUUC-Tni-120727 Tetraodon nigroviridis 84.21 0.00e+00 712.00
IUUC-Tre-122087 Trichoderma reesei 30.68 1.80e-02 33.50
IUUC-Tur-126585 Triticum urartu 30.00 3.00e-04 38.90
IUUC-Tbe-127552 Tupaia belangeri 93.94 0.00e+00 715.00
IUUC-Ttr-128903 Tursiops truncatus 98.83 0.00e+00 848.00
IUUC-Vpa-130347 Vicugna pacos 98.14 0.00e+00 842.00
IUUC-Xtr-131886 Xenopus tropicalis 89.61 0.00e+00 773.00
Created Date 25-Jun-2017

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