iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042444

UUCD1 version

UUC-GaA-00844

Ensembl Protein ID

ENSGACP00000021680.1

UniProt Accession

G3PVP1; G3PVP1_GASAC

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000016410.1	ENSGACT00000021721.1	ENSGACP00000021680.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-11	44.3	3373	3407
E3 activity/HECT	3.10e-82	277.1	4457	4791

Active Site

Position(s)	Description	Evidence
4760	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gH ++vt++++ sd +ll+++s D+++++W+++++
   Q: 3373 GHYNKVTSCSWnSDqNLLATCSQDKVVQLWNISQN 3407
           79999*******999****************8765 PP

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++elq+  + l+ +s+n+ + +  n d++l np     +h+  F+flG+l+++a+++++
   Q: 4457 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELQSGVVDLLIHSPNSFADVGCNTDRFLFNPaalleDHMVQFRFLGILMAVAIRTKK 4543
           556666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l++ +l   dleevd  +y++l+ i+++++s i+e ++++++  ++    +++ +    +pgG+ni+ t  N+ 
   Q: 4544 PLDLHLAPWVWKQLCSMPLGEPDLEEVDLLTYRTLQGILHLDNSGITEDNFHVMIPLDSFMAHSANGRLvpVVPGGQNISLTFGNRT 4630
           *******************************************************999988666666655589************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ ++yrl+e +++qv+a+reG+++++p  llsl+t+++le+l+cG +e++ve+lkk  +y++ + e+++ i wFw+ leef++
   Q: 4631 EYVERALDYRLHE-MDSQVAAVREGMSTIVPVPLLSLLTAQQLEQLVCGLPEVSVEMLKKLVRYRD-IAESHELIGWFWQSLEEFTN 4715
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  fL+Fv+g+srlP  + a++  ++f+i k d+  + lP+++TCf++++LP+Y+s+ il e+L+y i+++ ++++
   Q: 4716 EERVLFLRFVSGRSRLP-SNPADIT-QKFQIIKvDRPINGLPTAQTCFFLFRLPPYTSQAILAERLRYSIHNCPSIDM 4791
           *****************.6899999.556666637777**********************************988776 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MVPCQTHVLL KWQEHFNSSW AAEDSVQTAR RHGAAVLYNK LLLNKEVVTL AQPVQELVGP 60
RLPDFECESS ASAEKEEYLS SLLHSQRWLA HRMLTQTSYT LGLHHRLVVL QRIYYALHRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGCCTT GTCAGACCCA CGTGTTGCTG AAGTGGCAGG AGCACTTCAA TAGCTCCTGG 60
GCAGCGGAAG ACAGTGTACA GACAGCCAGG AGGCATGGAG CTGCGGTGCT CTACAATAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	58.47	0.00e+00	2083.00
IUUC-Atr-003065	Amborella trichopoda	34.41	8.00e-48	186.00
IUUC-Apl-003461	Anas platyrhynchos	58.58	0.00e+00	2108.00
IUUC-Aca-004452	Anolis carolinensis	58.11	0.00e+00	1990.00
IUUC-Aly-006545	Arabidopsis lyrata	34.90	4.00e-50	193.00
IUUC-Ame-011268	Astyanax mexicanus	66.39	0.00e+00	2727.00
IUUC-Bta-013213	Bos taurus	58.58	0.00e+00	2084.00
IUUC-Bol-015203	Brassica oleracea	34.07	2.00e-51	197.00
IUUC-Bra-017584	Brassica rapa	34.38	1.00e-46	182.00
IUUC-Cja-019298	Callithrix jacchus	58.45	0.00e+00	2086.00
IUUC-Cfa-021213	Canis familiaris	58.63	0.00e+00	2088.00
IUUC-Cpo-021674	Cavia porcellus	58.31	0.00e+00	2105.00
IUUC-Csa-023341	Chlorocebus sabaeus	58.18	0.00e+00	2081.00
IUUC-Dre-028289	Danio rerio	57.25	0.00e+00	2096.00
IUUC-Dno-029988	Dasypus novemcinctus	58.42	0.00e+00	2069.00
IUUC-Dor-030636	Dipodomys ordii	64.21	0.00e+00	1431.00
IUUC-Eca-033754	Equus caballus	58.55	0.00e+00	2086.00
IUUC-Fca-035900	Felis catus	58.61	0.00e+00	2097.00
IUUC-Fal-037034	Ficedula albicollis	48.80	0.00e+00	1996.00
IUUC-Gga-040321	Gallus gallus	58.53	0.00e+00	2136.00
IUUC-Gma-043808	Glycine max	32.65	9.00e-43	169.00
IUUC-Ggo-045134	Gorilla gorilla	58.20	0.00e+00	1972.00
IUUC-Hsa-046516	Homo sapiens	58.29	0.00e+00	2088.00
IUUC-Hvu-047529	Hordeum vulgare	35.29	2.00e-48	187.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	65.97	0.00e+00	1711.00
IUUC-Lch-049903	Latimeria chalumnae	58.30	0.00e+00	2132.00
IUUC-Loc-052805	Lepisosteus oculatus	63.85	0.00e+00	5589.00
IUUC-Laf-053426	Loxodonta africana	58.61	0.00e+00	2094.00
IUUC-Mcc-055826	Macaca mulatta	58.08	0.00e+00	2080.00
IUUC-Meu-056521	Macropus eugenii	49.22	0.00e+00	747.00
IUUC-Mga-059567	Meleagris gallopavo	60.33	0.00e+00	1206.00
IUUC-Mmr-061512	Microcebus murinus	58.67	0.00e+00	2089.00
IUUC-Mdo-062177	Monodelphis domestica	58.42	0.00e+00	2108.00
IUUC-Mmu-064373	Mus musculus	58.45	0.00e+00	2100.00
IUUC-Mpu-066148	Mustela putorius furo	58.71	0.00e+00	2097.00
IUUC-Mlu-067680	Myotis lucifugus	58.24	0.00e+00	2073.00
IUUC-Nle-069633	Nomascus leucogenys	57.66	0.00e+00	2033.00
IUUC-Ont-071249	Oreochromis niloticus	56.54	0.00e+00	2058.00
IUUC-Oan-073157	Ornithorhynchus anatinus	58.56	0.00e+00	2121.00
IUUC-Ocu-074841	Oryctolagus cuniculus	58.61	0.00e+00	2095.00
IUUC-Ola-086308	Oryzias latipes	75.15	0.00e+00	6744.00
IUUC-Oga-088459	Otolemur garnettii	58.46	0.00e+00	2087.00
IUUC-Oar-089888	Ovis aries	58.63	0.00e+00	2088.00
IUUC-Ptr-091114	Pan troglodytes	58.29	0.00e+00	2084.00
IUUC-Pan-092442	Papio anubis	58.08	0.00e+00	2080.00
IUUC-Psi-093833	Pelodiscus sinensis	58.30	0.00e+00	2113.00
IUUC-Pma-094275	Petromyzon marinus	60.29	0.00e+00	1226.00
IUUC-Pfo-096464	Poecilia formosa	77.83	0.00e+00	7116.00
IUUC-Pab-097760	Pongo abelii	58.29	0.00e+00	2076.00
IUUC-Pop-099121	Populus trichocarpa	34.69	3.00e-53	203.00
IUUC-Pca-100465	Procavia capensis	58.43	0.00e+00	2073.00
IUUC-Ppe-101345	Prunus persica	34.09	2.00e-50	194.00
IUUC-Pva-102950	Pteropus vampyrus	49.96	0.00e+00	1875.00
IUUC-Rno-104892	Rattus norvegicus	58.24	0.00e+00	2080.00
IUUC-Sha-106633	Sarcophilus harrisii	53.37	0.00e+00	2088.00
IUUC-Smo-108827	Selaginella moellendorffii	34.75	1.00e-51	198.00
IUUC-Sly-111155	Solanum lycopersicum	37.07	5.00e-53	203.00
IUUC-Stu-112166	Solanum tuberosum	31.78	2.00e-47	184.00
IUUC-Sar-113251	Sorex araneus	61.54	0.00e+00	998.00
IUUC-Sbi-114352	Sorghum bicolor	32.61	3.00e-48	187.00
IUUC-Ssc-116391	Sus scrofa	58.45	0.00e+00	2092.00
IUUC-Tgu-116554	Taeniopygia guttata	58.53	0.00e+00	2128.00
IUUC-Tru-118723	Takifugu rubripes	78.01	0.00e+00	7126.00
IUUC-Tni-120707	Tetraodon nigroviridis	57.90	0.00e+00	2120.00
IUUC-Tca-121094	Theobroma cacao	33.52	1.00e-50	195.00
IUUC-Tae-124157	Triticum aestivum	31.44	4.00e-45	177.00
IUUC-Tur-126300	Triticum urartu	35.29	6.00e-49	189.00
IUUC-Tbe-127346	Tupaia belangeri	55.96	0.00e+00	1558.00
IUUC-Ttr-128542	Tursiops truncatus	51.51	0.00e+00	1278.00
IUUC-Vpa-130611	Vicugna pacos	49.78	0.00e+00	1787.00
IUUC-Xtr-131933	Xenopus tropicalis	57.85	0.00e+00	2086.00
IUUC-Xma-134135	Xiphophorus maculatus	76.81	0.00e+00	6889.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence