iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049732

Ensembl Protein ID

ENSLACP00000011646.1

UniProt Accession

H3APS5; H3APS5_LATCH

Genbank Protein ID

ENSLACP00000011646

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AFYH01009532

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000010249.1	ENSLACT00000011735.1	ENSLACP00000011646.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.40e-100	334.3	160	511
UBD/ZnF/ZnF_UBP	7.40e-27	93.6	27	106

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+e+ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 160  TGLRNLGNTCFMNAILQSLSNIQEFCCYFKElpavelrsgktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 248
           7******************************999988887775555555566688899******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    +  ++++  ls+  ++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 249  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGYNGVSCSVISQENLGLSS-GSKCCINGASTVVTSIFGGVLQNEVNCLICGTESRKFD 336
           *****************************775555555555555555554.4688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         +l+dcL+sft  eel++ + y c kckk+q+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 337  PFLDLSLDIPSHFRNKRSknqengptcTLRDCLRSFTDLEELDETELYMCHKCKKRQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 423
           **********77655555667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++v+fpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v++   ++aY+lf
   Q: 424  KVDTYVDFPLRgLDMKCYLLEPENSGPESCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVVK---AKAYILF 508
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 509  YVE 511
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl..................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cL c+sv+CGRyv+gHa+kHye++q+p+                  ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLACSSVHCGRYVNGHAKKHYEDSQVPVssckksekhdkeklqhtvCMDCSSYSTYCYRCDDFVVN 106
           9*****************************************************************************85 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MECPHLNSSV CISPESAKFP NGSPSSWCCS VCRSNKSPWV CLACSSVHCG RYVNGHAKKH 60
YEDSQVPVSS CKKSEKHDKE KLQHTVCMDC SSYSTYCYRC DDFVVNDTKL GLVQKLREHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTGTC CCCACCTCAA CTCCAGCGTT TGCATCTCCC CGGAGTCGGC CAAGTTCCCG 60
AACGGTTCGC CTTCCTCCTG GTGCTGCAGT GGTGAGTCTC CTCGCCGCGC AGCTTCGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lcm:102350495

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	90.77	0.00e+00	910.00
IUUC-Apl-003358	Anas platyrhynchos	91.43	0.00e+00	849.00
IUUC-Aca-004454	Anolis carolinensis	88.52	0.00e+00	801.00
IUUC-Ame-011544	Astyanax mexicanus	77.34	0.00e+00	750.00
IUUC-Bta-012738	Bos taurus	90.60	0.00e+00	870.00
IUUC-Cel-018186	Caenorhabditis elegans	37.85	5.00e-61	228.00
IUUC-Cja-018893	Callithrix jacchus	90.77	0.00e+00	875.00
IUUC-Cfa-020607	Canis familiaris	91.35	0.00e+00	876.00
IUUC-Cpo-021828	Cavia porcellus	89.04	0.00e+00	858.00
IUUC-Csa-023884	Chlorocebus sabaeus	92.67	0.00e+00	731.00
IUUC-Cho-024863	Choloepus hoffmanni	82.31	0.00e+00	760.00
IUUC-Dre-028452	Danio rerio	75.57	0.00e+00	774.00
IUUC-Dno-029531	Dasypus novemcinctus	90.20	0.00e+00	810.00
IUUC-Dor-030913	Dipodomys ordii	81.25	2.00e-161	561.00
IUUC-Ete-032611	Echinops telfairi	85.19	0.00e+00	817.00
IUUC-Eca-033622	Equus caballus	91.22	0.00e+00	815.00
IUUC-Eeu-035268	Erinaceus europaeus	86.30	0.00e+00	744.00
IUUC-Fca-035801	Felis catus	91.22	0.00e+00	843.00
IUUC-Fal-036749	Ficedula albicollis	90.02	0.00e+00	807.00
IUUC-Gmo-039598	Gadus morhua	76.32	0.00e+00	785.00
IUUC-Gga-040883	Gallus gallus	91.63	0.00e+00	822.00
IUUC-Gac-042235	Gasterosteus aculeatus	76.54	0.00e+00	759.00
IUUC-Ggo-044767	Gorilla gorilla	86.35	0.00e+00	775.00
IUUC-Hsa-046581	Homo sapiens	91.15	0.00e+00	902.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	90.77	0.00e+00	872.00
IUUC-Loc-052371	Lepisosteus oculatus	89.29	0.00e+00	929.00
IUUC-Laf-054565	Loxodonta africana	91.15	0.00e+00	873.00
IUUC-Mcc-055522	Macaca mulatta	91.35	0.00e+00	905.00
IUUC-Meu-056754	Macropus eugenii	80.05	1.00e-165	575.00
IUUC-Mga-060095	Meleagris gallopavo	88.79	7.00e-173	599.00
IUUC-Mmr-060839	Microcebus murinus	90.96	0.00e+00	874.00
IUUC-Mdo-062339	Monodelphis domestica	93.30	0.00e+00	726.00
IUUC-Mmu-063638	Mus musculus	89.42	0.00e+00	839.00
IUUC-Mpu-066647	Mustela putorius furo	92.61	0.00e+00	722.00
IUUC-Mlu-067921	Myotis lucifugus	90.00	0.00e+00	835.00
IUUC-Nle-069752	Nomascus leucogenys	91.54	0.00e+00	905.00
IUUC-Opr-070636	Ochotona princeps	77.31	0.00e+00	682.00
IUUC-Ont-071638	Oreochromis niloticus	78.69	0.00e+00	731.00
IUUC-Oan-073417	Ornithorhynchus anatinus	85.77	0.00e+00	838.00
IUUC-Ocu-074620	Oryctolagus cuniculus	89.23	0.00e+00	861.00
IUUC-Ola-087281	Oryzias latipes	78.89	0.00e+00	645.00
IUUC-Olu-087697	Ostreococcus lucimarinus	41.31	7.00e-53	200.00
IUUC-Oga-088448	Otolemur garnettii	90.58	0.00e+00	898.00
IUUC-Oar-090132	Ovis aries	90.77	0.00e+00	872.00
IUUC-Ptr-090696	Pan troglodytes	91.24	0.00e+00	845.00
IUUC-Pan-092124	Papio anubis	91.15	0.00e+00	902.00
IUUC-Psi-093801	Pelodiscus sinensis	93.07	0.00e+00	724.00
IUUC-Pma-094472	Petromyzon marinus	71.74	7.00e-94	335.00
IUUC-Pfo-096330	Poecilia formosa	77.69	0.00e+00	805.00
IUUC-Pab-098191	Pongo abelii	91.54	0.00e+00	905.00
IUUC-Pca-100341	Procavia capensis	88.45	0.00e+00	669.00
IUUC-Pva-103177	Pteropus vampyrus	91.14	0.00e+00	871.00
IUUC-Rno-105048	Rattus norvegicus	88.46	0.00e+00	830.00
IUUC-Sha-107429	Sarcophilus harrisii	90.74	0.00e+00	818.00
IUUC-Sar-113024	Sorex araneus	89.98	0.00e+00	765.00
IUUC-Ssc-115749	Sus scrofa	88.61	5.00e-141	493.00
IUUC-Tgu-117277	Taeniopygia guttata	90.00	0.00e+00	834.00
IUUC-Tru-117844	Takifugu rubripes	78.65	0.00e+00	807.00
IUUC-Tsy-119456	Tarsius syrichta	88.34	0.00e+00	805.00
IUUC-Tni-120251	Tetraodon nigroviridis	74.81	0.00e+00	814.00
IUUC-Tbe-127423	Tupaia belangeri	84.81	0.00e+00	792.00
IUUC-Ttr-128401	Tursiops truncatus	84.46	0.00e+00	734.00
IUUC-Vpa-130549	Vicugna pacos	79.76	2.00e-149	521.00
IUUC-Xtr-131892	Xenopus tropicalis	81.59	0.00e+00	790.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence