iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120251

UUCD1 version

UUC-TeN-01148

Ensembl Protein ID

ENSTNIP00000011245.1

UniProt Accession

H3CSL1; H3CSL1_TETNG

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000008410.1	ENSTNIT00000011427.1	ENSTNIP00000011245.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-95	320.0	161	512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             ++  + +++ e++ +l+++++k + +lw+++++a+sp +l+ +++
   Q: 161  TGLRNLGNTCFMNAILQSLSNIEQFSCYFKElpavslrsgktAGRRMYHTRSQGESSVSLVEEFRKTLCSLWQGSQTAFSPDSLFYTIW 249
           7******************************888888777664444444455588899******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l++el++++n   ++++ +d  +l+    +   + + s+++ +F+g l++++ cl c+++s +++
   Q: 250  KIMPSFRGYQQQDAHEFMRYLLDHLHRELQNSRNGASHTASPQDGVRLTAADGKCCINGTASVVTSIFGGILQNEVNCLICGTESRKFD 338
           *****************************9999999999999999999999************************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         +l+dcL+sft  eel++ + y+c kckk+q+++kk++++klP+vL+lhLkRf++  +   r+
   Q: 339  PFLDLSLDIPSQFRQKRSkdqepgptcTLSDCLRSFTDLEELDDTELYFCHKCKKRQKSTKKFWVQKLPKVLCLHLKRFHW--TAFLRN 425
           **********7776655577899********************************************************77..558*** PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfY 335
           ki+++vefpl+ Ld++ ++ +pe++  e++ Y+L+av      ++sGHY+ay  + +++W++f+Ds+Vt ++e+ v +   ++aY+lfY
   Q: 426  KIDTYVEFPLKgLDMRGYLLEPENSLPESCVYDLVAVYKSIHRVGSGHYTAYGSH-EDRWYHFNDSTVTLTSEDAVRK---AKAYILFY 510
           *************************************999999************.889*******************...******** PP
   S: 336  kr 337
            +
   Q: 511  VE 512
           76 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MECSHLNSGV SCPIDSSRFP NGTPSSWCCS VCRSNKSPWI CLTCLVVHCG RYVNGHAKKH 60
FEETQAVGVS QRKNDKQEKE KYHHCVCMDC SSYSVFCYRC DDFVVNDTKL GQVQKAREHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTGTT CTCATTTGAA CTCCGGCGTA AGCTGCCCTA TCGATTCCTC AAGGTTTCCT 60
AACGGGACTC CGTCCTCTTG GTGTTGCAGC GGTAAGAAAA AAAAAAAAAA ATATATATAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	74.81	0.00e+00	760.00
IUUC-Apl-003358	Anas platyrhynchos	75.51	0.00e+00	697.00
IUUC-Aca-004454	Anolis carolinensis	73.54	0.00e+00	678.00
IUUC-Ame-011544	Astyanax mexicanus	75.44	0.00e+00	754.00
IUUC-Bta-012738	Bos taurus	75.05	0.00e+00	723.00
IUUC-Cel-018186	Caenorhabditis elegans	34.70	5.00e-55	208.00
IUUC-Cja-018893	Callithrix jacchus	74.81	0.00e+00	724.00
IUUC-Cfa-020607	Canis familiaris	74.81	0.00e+00	723.00
IUUC-Cpo-021828	Cavia porcellus	74.81	0.00e+00	720.00
IUUC-Csa-023884	Chlorocebus sabaeus	76.83	5.00e-174	603.00
IUUC-Cho-024863	Choloepus hoffmanni	68.46	0.00e+00	634.00
IUUC-Dre-028452	Danio rerio	76.49	0.00e+00	796.00
IUUC-Dno-029531	Dasypus novemcinctus	74.90	0.00e+00	673.00
IUUC-Dor-030913	Dipodomys ordii	69.64	1.00e-136	479.00
IUUC-Ete-032611	Echinops telfairi	70.77	0.00e+00	676.00
IUUC-Eca-033622	Equus caballus	75.10	0.00e+00	679.00
IUUC-Eeu-035268	Erinaceus europaeus	72.39	5.00e-180	623.00
IUUC-Fca-035801	Felis catus	75.10	0.00e+00	694.00
IUUC-Fal-036749	Ficedula albicollis	75.36	0.00e+00	681.00
IUUC-Gmo-039598	Gadus morhua	80.12	0.00e+00	827.00
IUUC-Gga-040883	Gallus gallus	75.51	0.00e+00	679.00
IUUC-Gac-042235	Gasterosteus aculeatus	82.88	0.00e+00	856.00
IUUC-Ggo-044767	Gorilla gorilla	70.47	0.00e+00	632.00
IUUC-Hsa-046581	Homo sapiens	74.42	0.00e+00	736.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	74.62	0.00e+00	721.00
IUUC-Lch-049732	Latimeria chalumnae	74.90	0.00e+00	776.00
IUUC-Loc-052371	Lepisosteus oculatus	77.69	0.00e+00	800.00
IUUC-Laf-054565	Loxodonta africana	74.04	0.00e+00	718.00
IUUC-Mcc-055522	Macaca mulatta	74.62	0.00e+00	739.00
IUUC-Meu-056754	Macropus eugenii	66.85	3.00e-132	464.00
IUUC-Mga-060095	Meleagris gallopavo	73.75	2.00e-142	498.00
IUUC-Mmr-060839	Microcebus murinus	74.81	0.00e+00	725.00
IUUC-Mdo-062339	Monodelphis domestica	76.67	2.00e-173	602.00
IUUC-Mmu-063638	Mus musculus	74.23	0.00e+00	705.00
IUUC-Mpu-066647	Mustela putorius furo	76.91	3.00e-174	604.00
IUUC-Mlu-067921	Myotis lucifugus	75.51	0.00e+00	696.00
IUUC-Nle-069752	Nomascus leucogenys	75.00	0.00e+00	741.00
IUUC-Opr-070636	Ochotona princeps	65.38	6.00e-165	573.00
IUUC-Ont-071638	Oreochromis niloticus	86.11	0.00e+00	820.00
IUUC-Oan-073417	Ornithorhynchus anatinus	70.38	0.00e+00	683.00
IUUC-Ocu-074620	Oryctolagus cuniculus	75.00	0.00e+00	724.00
IUUC-Ola-087281	Oryzias latipes	84.45	0.00e+00	711.00
IUUC-Olu-087697	Ostreococcus lucimarinus	37.62	6.00e-52	197.00
IUUC-Oga-088448	Otolemur garnettii	74.62	0.00e+00	741.00
IUUC-Oar-090132	Ovis aries	74.81	0.00e+00	724.00
IUUC-Ptr-090696	Pan troglodytes	74.95	0.00e+00	695.00
IUUC-Pan-092124	Papio anubis	74.42	0.00e+00	736.00
IUUC-Psi-093801	Pelodiscus sinensis	75.75	2.00e-171	595.00
IUUC-Pma-094300	Petromyzon marinus	66.42	1.00e-97	348.00
IUUC-Pfo-096330	Poecilia formosa	83.43	0.00e+00	877.00
IUUC-Pab-098191	Pongo abelii	74.81	0.00e+00	740.00
IUUC-Pca-100341	Procavia capensis	73.53	5.00e-160	557.00
IUUC-Pva-103177	Pteropus vampyrus	73.65	0.00e+00	711.00
IUUC-Rno-105048	Rattus norvegicus	73.65	0.00e+00	697.00
IUUC-Sha-107429	Sarcophilus harrisii	74.65	0.00e+00	678.00
IUUC-Sar-113024	Sorex araneus	75.05	0.00e+00	637.00
IUUC-Ssc-115749	Sus scrofa	72.76	1.00e-117	415.00
IUUC-Tgu-117277	Taeniopygia guttata	75.82	0.00e+00	694.00
IUUC-Tru-117844	Takifugu rubripes	91.54	0.00e+00	947.00
IUUC-Tsy-119456	Tarsius syrichta	72.39	0.00e+00	668.00
IUUC-Tbe-127423	Tupaia belangeri	70.96	0.00e+00	670.00
IUUC-Ttr-128401	Tursiops truncatus	68.92	3.00e-174	604.00
IUUC-Vpa-130549	Vicugna pacos	66.67	4.00e-123	434.00
IUUC-Xtr-131892	Xenopus tropicalis	68.58	0.00e+00	659.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence