iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045669

UUCD1 version

UUC-HoS-01101

Ensembl Protein ID

ENSP00000265560.4

UniProt Accession

Q13107; A8K6Y0; C9IY91; O43452; O43453; Q08AK8; UBP4_HUMAN

Genbank Protein ID

AAB72237.1; AAC27355.1; AAC27356.1; BAF84484.1; AAI25131.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4; Ubiquitous nuclear protein homolog

Genbank Nucleotide ID

U20657; AF017305; AF017306; AK291795; AC121247

Gene Name

USP4; UNP; UNPH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114316.12	ENST00000351842.8	ENSP00000341028.4
ENSG00000114316.12	ENST00000265560.8	ENSP00000265560.4
ENSG00000114316.12	ENST00000431357.1	ENSP00000399079.1
ENSG00000114316.12	ENST00000416417.5	ENSP00000400623.1
ENSG00000114316.12	ENST00000415188.1	ENSP00000408274.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20595234
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	23022198

Classification

Family	E-value	Score	Start	End
DUB/USP	2.80e-113	380.2	302	923
ULD/UDP/UBQ/UBQ_Other	7.40e-18	65.9	143	221
ULD/UDP/UBQ/UBQ_Other	8.9e-07	21.7	492	570

Active Site

Position(s)	Description	Evidence
311	Nucleophile
881	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqD 91
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++ +v+pr+++++++++a++fsgy+qqD
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQD 393
           7******************************9************************************************************ PP
   S: 92   aqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l+lp+p 
   Q: 394  SQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPL 483
           ***************************8888..5555556777************************************************* PP
   S: 179  keetkke..................................................................................... 185
           k+++ +e                                                                                     
   Q: 484  KKDRVMEvflvpadphcrptqyrvtvplmgavsdlcealsrlsgiaaenmvvadvynhrfhkifqmdeglnhimprddifvyevcstsvdgs 575
           **99999************************************************************************************* PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 576  ecvtlpvyfrerksrpsstssasalygqplllsvpkhkltleslyqavcdrisryvkqplpdefgssplepgacngsrnscegedeeemehq 667
           ******************************************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 668  eegkeqlsetegsgedepgndpsettqkkikgqpcpkrlftfslvnsygtadinslaadgkllklnsrstlamdwdsetrrlyydeqeseay 759
           ******************************************************************************************** PP
   S: 186  .................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.L 259
                             l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++   r k+++ vefp++ L
   Q: 760  ekhvsmlqpqkkkkttvALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY--WRDKLDTVVEFPIRgL 849
           *********************************************************************99885..567************* PP
   S: 260  dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++s+f+++ +    +++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+  +e+++++   + aYvlfY+rr
   Q: 850  NMSEFVCNLSA---RPYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSNVSLASEDQIVT---KAAYVLFYQRR 923
           *****999443...49**************************52666*******************...*********96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgs.eltlk..vnpsdtVaeLKekiekklgippeqqrLi..yk...GkiLeddktLadyglkdgstihllekksg 75
           + v+ + ++  ++++  v+ +  V++L+e ++++ gi +e +     y    +ki+++d  L+  +++++++i+++e++s+
   Q: 492  FLVPADPHCrPTQYRvtVPLMGAVSDLCEALSRLSGIAAENMVVAdvYNhrfHKIFQMDEGLN--HIMPRDDIFVYEVCST 570
           6799999********7667777****************887666665448899**********..89**********9985 PP

Organism

Homo sapiens

Functional Description
(View)

Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.

Protein Sequence
(Fasta)

MAEGGGCRER PDAETQKSEL GPLMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTCAGTAT GAAGAGCTGA CGGAATTCTG CGGTGGGCCA GGTGGCTCTG GCGTCGACTG 60
TTTAAGGCGA CTGTTAATGA CTACAACACA CCATTGAGTC TTGGTCCCAA GGCGCTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005764--C:lysosome
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031685--F:adenosine receptor binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7375

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	93.78	0.00e+00	1675.00
IUUC-Atr-002991	Amborella trichopoda	35.65	3.00e-144	506.00
IUUC-Apl-004068	Anas platyrhynchos	70.25	0.00e+00	1204.00
IUUC-Aca-004459	Anolis carolinensis	69.30	0.00e+00	1231.00
IUUC-Aly-006044	Arabidopsis lyrata	36.53	9.00e-150	524.00
IUUC-Ath-007288	Arabidopsis thaliana	36.24	8.00e-151	528.00
IUUC-Ang-009562	Aspergillus niger	45.16	2.00e-55	211.00
IUUC-Bta-012929	Bos taurus	94.08	0.00e+00	1721.00
IUUC-Bdi-014013	Brachypodium distachyon	37.21	9.00e-152	531.00
IUUC-Bol-015244	Brassica oleracea	37.31	2.00e-153	536.00
IUUC-Bra-016885	Brassica rapa	37.12	4.00e-151	529.00
IUUC-Cja-018798	Callithrix jacchus	96.05	0.00e+00	1714.00
IUUC-Cfa-020599	Canis familiaris	95.02	0.00e+00	1717.00
IUUC-Cpo-022144	Cavia porcellus	90.22	0.00e+00	1624.00
IUUC-Csa-023770	Chlorocebus sabaeus	98.24	0.00e+00	1660.00
IUUC-Cho-024595	Choloepus hoffmanni	84.56	0.00e+00	1085.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	43.75	1.00e-60	229.00
IUUC-Dre-027869	Danio rerio	69.28	0.00e+00	890.00
IUUC-Dno-029316	Dasypus novemcinctus	91.91	0.00e+00	1716.00
IUUC-Ete-032970	Echinops telfairi	82.90	0.00e+00	1068.00
IUUC-Eca-034012	Equus caballus	95.02	0.00e+00	1699.00
IUUC-Eeu-035158	Erinaceus europaeus	77.50	0.00e+00	797.00
IUUC-Fca-035373	Felis catus	91.18	0.00e+00	1680.00
IUUC-Fal-037634	Ficedula albicollis	74.97	0.00e+00	1298.00
IUUC-Fox-037986	Fusarium oxysporum	44.49	6.00e-64	240.00
IUUC-Fso-038291	Fusarium solani	44.49	1.00e-63	239.00
IUUC-Gmo-038866	Gadus morhua	68.39	0.00e+00	852.00
IUUC-Ggr-039740	Gaeumannomyces graminis	44.32	2.00e-62	235.00
IUUC-Gga-040729	Gallus gallus	67.92	0.00e+00	1259.00
IUUC-Gac-042631	Gasterosteus aculeatus	67.26	0.00e+00	1243.00
IUUC-Ggo-045337	Gorilla gorilla	97.35	0.00e+00	1603.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	94.50	0.00e+00	1722.00
IUUC-Lch-050533	Latimeria chalumnae	68.88	0.00e+00	1182.00
IUUC-Lpe-051424	Leersia perrieri	36.60	2.00e-148	520.00
IUUC-Loc-051800	Lepisosteus oculatus	65.59	0.00e+00	1297.00
IUUC-Laf-053803	Loxodonta africana	94.29	0.00e+00	1708.00
IUUC-Mcc-055556	Macaca mulatta	94.29	0.00e+00	1671.00
IUUC-Meu-056742	Macropus eugenii	72.65	0.00e+00	1313.00
IUUC-Mor-056985	Magnaporthe oryzae	43.22	6.00e-62	233.00
IUUC-Mpo-057486	Magnaporthe poae	45.05	2.00e-62	235.00
IUUC-Mtr-058138	Medicago truncatula	44.50	5.00e-138	485.00
IUUC-Mga-059300	Meleagris gallopavo	70.98	0.00e+00	1226.00
IUUC-Mdo-061848	Monodelphis domestica	84.09	0.00e+00	1552.00
IUUC-Mmu-063960	Mus musculus	90.76	0.00e+00	1659.00
IUUC-Mpu-066920	Mustela putorius furo	95.02	0.00e+00	1719.00
IUUC-Mlu-068088	Myotis lucifugus	92.63	0.00e+00	1692.00
IUUC-Nfi-068330	Neosartorya fischeri	45.20	2.00e-54	209.00
IUUC-Ncr-068879	Neurospora crassa	32.19	8.00e-68	253.00
IUUC-Nle-070010	Nomascus leucogenys	98.86	0.00e+00	1790.00
IUUC-Opr-070740	Ochotona princeps	90.01	0.00e+00	1206.00
IUUC-Ont-072573	Oreochromis niloticus	64.31	0.00e+00	1256.00
IUUC-Oan-073363	Ornithorhynchus anatinus	76.99	0.00e+00	1411.00
IUUC-Ocu-074242	Oryctolagus cuniculus	89.38	0.00e+00	1594.00
IUUC-Olo-080315	Oryza longistaminata	36.31	2.00e-146	513.00
IUUC-Ola-086553	Oryzias latipes	68.52	0.00e+00	1271.00
IUUC-Olu-087717	Ostreococcus lucimarinus	39.97	2.00e-122	433.00
IUUC-Oga-088562	Otolemur garnettii	86.73	0.00e+00	1499.00
IUUC-Oar-090439	Ovis aries	93.56	0.00e+00	1701.00
IUUC-Ptr-090801	Pan troglodytes	99.69	0.00e+00	1801.00
IUUC-Pan-092717	Papio anubis	93.15	0.00e+00	1643.00
IUUC-Psi-093942	Pelodiscus sinensis	74.10	0.00e+00	1298.00
IUUC-Pab-098522	Pongo abelii	99.05	0.00e+00	1317.00
IUUC-Pca-100161	Procavia capensis	82.88	0.00e+00	1462.00
IUUC-Rno-106081	Rattus norvegicus	89.62	0.00e+00	1659.00
IUUC-Sha-106937	Sarcophilus harrisii	82.89	0.00e+00	1513.00
IUUC-Sit-109948	Setaria italica	36.71	2.00e-141	496.00
IUUC-Sly-111746	Solanum lycopersicum	38.03	3.00e-153	536.00
IUUC-Stu-112671	Solanum tuberosum	37.82	5.00e-151	528.00
IUUC-Sar-113542	Sorex araneus	87.34	0.00e+00	1592.00
IUUC-Sbi-114874	Sorghum bicolor	36.32	1.00e-143	504.00
IUUC-Ssc-115637	Sus scrofa	94.91	0.00e+00	1706.00
IUUC-Tgu-117267	Taeniopygia guttata	72.06	0.00e+00	1300.00
IUUC-Tru-118634	Takifugu rubripes	67.05	0.00e+00	1203.00
IUUC-Tca-121001	Theobroma cacao	36.01	6.00e-154	538.00
IUUC-Tur-126478	Triticum urartu	40.56	4.00e-120	425.00
IUUC-Tbe-127669	Tupaia belangeri	76.04	0.00e+00	899.00
IUUC-Ttr-128778	Tursiops truncatus	93.35	0.00e+00	1689.00
IUUC-Uma-129498	Ustilago maydis	40.90	9.00e-70	259.00
IUUC-Vda-129781	Verticillium dahliae	44.60	4.00e-65	243.00
IUUC-Vpa-130571	Vicugna pacos	96.46	0.00e+00	1135.00
IUUC-Xtr-132305	Xenopus tropicalis	69.01	0.00e+00	1278.00
IUUC-Yli-134392	Yarrowia lipolytica	43.01	1.00e-61	232.00
IUUC-Zma-135699	Zea mays	36.36	1.00e-143	504.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence