iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132275

Ensembl Protein ID

ENSXETP00000027387.3

UniProt Accession

Q66II3; GRB2_XENTR

Genbank Protein ID

AAH81338.1

Protein Name

Growth factor receptor-bound protein 2; Adapter protein GRB2; SH2/SH3 adapter GRB2

Genbank Nucleotide ID

BC081338

Gene Name

grb2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000012520.3	ENSXETT00000027387.3	ENSXETP00000027387.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.60e-36	124.2	169	226

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  +vq+l+d+++q+d+eL +++Gd+++v+  ++ d +W+kg  +  g+ G+fP n+v+ ++
   Q: 169  QPTYVQALFDFDPQEDGELGFRRGDFIQVV--DNSDPNWWKG--TCLGQTGMFPRNYVTPVN 226
           5689**************************..9*********..89*************997 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Promotes meiotic reinitiation during oocyte maturation.

Protein Sequence
(Fasta)

MEAVAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAAAAGCT CTATCGAGAG GTGGGGAGAT GAGTGTCAGC CGTGTCGTAG AAGTCGATGT 60
AGCGGTGGGT GGGTGTCCGG CTGTTGTTGA GTTGAAAGTC CCATGGGCTG CCAGGGAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0469--Meiosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0005154--F:epidermal growth factor receptor binding
GO:0043560--F:insulin receptor substrate binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0051321--P:meiotic cell cycle
GO:0007275--P:multicellular organism development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

xtr:493492

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	90.69	4.00e-108	383.00
IUUC-Apl-003322	Anas platyrhynchos	91.63	1.00e-108	385.00
IUUC-Aca-005193	Anolis carolinensis	92.58	5.00e-124	436.00
IUUC-Ago-007965	Ashbya gossypii	48.15	2.00e-12	65.50
IUUC-Ame-010929	Astyanax mexicanus	86.90	2.00e-117	414.00
IUUC-Bta-012932	Bos taurus	91.70	3.00e-123	433.00
IUUC-Cel-018665	Caenorhabditis elegans	55.46	3.00e-70	257.00
IUUC-Cja-019225	Callithrix jacchus	91.70	3.00e-123	433.00
IUUC-Cfa-020887	Canis familiaris	91.70	3.00e-123	433.00
IUUC-Cpo-022488	Cavia porcellus	91.70	3.00e-123	433.00
IUUC-Csa-023326	Chlorocebus sabaeus	91.70	3.00e-123	433.00
IUUC-Cho-024953	Choloepus hoffmanni	74.67	2.00e-91	327.00
IUUC-Cin-025144	Ciona intestinalis	59.64	2.00e-72	265.00
IUUC-Csv-026210	Ciona savignyi	57.40	3.00e-69	254.00
IUUC-Dre-028403	Danio rerio	89.52	4.00e-121	426.00
IUUC-Dno-029187	Dasypus novemcinctus	90.39	5.00e-122	429.00
IUUC-Dor-030763	Dipodomys ordii	91.70	3.00e-123	433.00
IUUC-Dme-031741	Drosophila melanogaster	60.71	2.00e-76	278.00
IUUC-Ete-032354	Echinops telfairi	64.47	2.00e-77	281.00
IUUC-Eca-033222	Equus caballus	91.70	3.00e-123	433.00
IUUC-Eeu-034513	Erinaceus europaeus	97.98	5.00e-54	203.00
IUUC-Fca-036294	Felis catus	91.70	3.00e-123	433.00
IUUC-Fal-037130	Ficedula albicollis	91.70	2.00e-123	433.00
IUUC-Gmo-039546	Gadus morhua	88.65	1.00e-119	421.00
IUUC-Gga-041139	Gallus gallus	92.14	6.00e-124	436.00
IUUC-Gac-041968	Gasterosteus aculeatus	89.52	1.00e-120	424.00
IUUC-Ggo-044562	Gorilla gorilla	91.70	3.00e-123	433.00
IUUC-Hsa-046730	Homo sapiens	91.70	3.00e-123	433.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	91.70	3.00e-123	433.00
IUUC-Lch-050230	Latimeria chalumnae	96.99	2.00e-74	271.00
IUUC-Loc-052723	Lepisosteus oculatus	91.27	3.00e-122	430.00
IUUC-Laf-053774	Loxodonta africana	90.83	2.00e-122	431.00
IUUC-Mcc-054603	Macaca mulatta	91.70	3.00e-123	433.00
IUUC-Meu-056173	Macropus eugenii	75.98	1.00e-96	345.00
IUUC-Mga-059950	Meleagris gallopavo	92.14	6.00e-124	436.00
IUUC-Mmr-060878	Microcebus murinus	91.70	3.00e-123	433.00
IUUC-Mdo-062454	Monodelphis domestica	92.14	6.00e-124	436.00
IUUC-Mmu-063913	Mus musculus	91.27	6.00e-123	432.00
IUUC-Mpu-066125	Mustela putorius furo	91.70	3.00e-123	433.00
IUUC-Mlu-068007	Myotis lucifugus	91.70	3.00e-123	433.00
IUUC-Nle-069101	Nomascus leucogenys	91.70	3.00e-123	433.00
IUUC-Opr-071075	Ochotona princeps	91.70	3.00e-123	433.00
IUUC-Ont-072253	Oreochromis niloticus	86.46	6.00e-117	412.00
IUUC-Oan-073107	Ornithorhynchus anatinus	50.44	7.00e-58	216.00
IUUC-Ocu-074583	Oryctolagus cuniculus	91.70	3.00e-123	433.00
IUUC-Ola-086586	Oryzias latipes	95.57	2.00e-87	315.00
IUUC-Oga-089047	Otolemur garnettii	91.70	3.00e-123	433.00
IUUC-Oar-089904	Ovis aries	84.78	3.00e-112	396.00
IUUC-Ptr-090678	Pan troglodytes	91.70	3.00e-123	433.00
IUUC-Pan-092090	Papio anubis	91.70	3.00e-123	433.00
IUUC-Psi-093765	Pelodiscus sinensis	91.70	2.00e-123	433.00
IUUC-Pma-094650	Petromyzon marinus	81.58	1.00e-109	388.00
IUUC-Pfo-096131	Poecilia formosa	89.08	2.00e-120	424.00
IUUC-Pab-098709	Pongo abelii	91.70	3.00e-123	433.00
IUUC-Pca-100581	Procavia capensis	90.64	1.00e-107	381.00
IUUC-Pva-103066	Pteropus vampyrus	91.70	3.00e-123	433.00
IUUC-Rno-105224	Rattus norvegicus	91.70	3.00e-123	433.00
IUUC-Sce-106302	Saccharomyces cerevisiae	53.70	2.00e-15	75.90
IUUC-Sha-107247	Sarcophilus harrisii	92.12	3.00e-109	386.00
IUUC-Sar-113277	Sorex araneus	76.86	4.00e-97	347.00
IUUC-Ssc-115478	Sus scrofa	91.70	3.00e-123	433.00
IUUC-Tgu-117479	Taeniopygia guttata	91.27	5.00e-123	432.00
IUUC-Tru-118451	Takifugu rubripes	87.34	4.00e-111	393.00
IUUC-Tsy-119029	Tarsius syrichta	92.41	1.00e-81	295.00
IUUC-Tni-120563	Tetraodon nigroviridis	48.00	2.00e-59	221.00
IUUC-Tbe-128097	Tupaia belangeri	91.27	3.00e-122	430.00
IUUC-Ttr-128871	Tursiops truncatus	98.72	8.00e-90	321.00
IUUC-Vpa-130754	Vicugna pacos	91.70	3.00e-123	433.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence