iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000003730.2	ENSMLUT00000003728.2	ENSMLUP00000003396.2
ENSMLUG00000003730.2	ENSMLUT00000022705.1	ENSMLUP00000016326.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	4.90e-21	74.5	2	72

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 3    ltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkk 73
           ++v++++++ f++ev++ +++ +lKe++ak++gvp++q+++I+aGk+L++d  ++++++ ++s+vh+v+++
   Q: 2    VFVRFNSSHGFPVEVDSATSIFQLKEEVAKRQGVPADQLRVIFAGKELRNDLVVQSCDLGQQSIVHVVLRP 72
           89***99999**********************************************************986 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

PVFVRFNSSH GFPVEVDSAT SIFQLKEEVA KRQGVPADQL RVIFAGKELR NDLVVQSCDL 60
GQQSIVHVVL RPGREGPAMA TGRDRPRGTA GAFAREPESL TRVDFSSSVL PTDSAGLAVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGTGTTCG TGAGGTTCAA CTCCAGCCAC GGTTTCCCAG TGGAGGTGGA TTCTGCCACC 60
AGCATCTTCC AGCTCAAGGA GGAGGTTGCT AAGCGACAGG GGGTTCCAGC CGACCAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR031127--E3_UB_ligase_RBR
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0071797--C:LUBAC complex
GO:0005739--C:mitochondrion
GO:0099073--C:mitochondrion-derived vesicle
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0043234--C:protein complex
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008344--P:adult locomotory behavior
GO:0070842--P:aggresome assembly
GO:0097237--P:cellular response to toxic substance
GO:0042417--P:dopamine metabolic process
GO:0051583--P:dopamine uptake involved in synaptic transmission
GO:0010994--P:free ubiquitin chain polymerization
GO:0007612--P:learning
GO:0000423--P:macromitophagy
GO:0099074--P:mitochondrion to lysosome transport
GO:0044828--P:negative regulation by host of viral genome replication
GO:0032232--P:negative regulation of actin filament bundle assembly
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:1903382--P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542--P:negative regulation of exosomal secretion
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion
GO:1905366--P:negative regulation of intralumenal vesicle formation
GO:1902254--P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1903377--P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1902283--P:negative regulation of primary amine oxidase activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:1904049--P:negative regulation of spontaneous neurotransmitter secretion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042415--P:norepinephrine metabolic process
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:0043388--P:positive regulation of DNA binding
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010636--P:positive regulation of mitochondrial fusion
GO:0051582--P:positive regulation of neurotransmitter uptake
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:1902530--P:positive regulation of protein linear polyubiquitination
GO:1905477--P:positive regulation of protein localization to membrane
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0050821--P:protein stabilization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042053--P:regulation of dopamine metabolic process
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0034976--P:response to endoplasmic reticulum stress
GO:0001964--P:startle response
GO:0035249--P:synaptic transmission, glutamatergic

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	83.33	1.00e-136	479.00
IUUC-Apl-003304	Anas platyrhynchos	75.11	1.00e-95	342.00
IUUC-Ame-011856	Astyanax mexicanus	59.61	6.00e-115	407.00
IUUC-Bta-013014	Bos taurus	77.93	2.00e-154	538.00
IUUC-Cel-018687	Caenorhabditis elegans	25.24	3.00e-23	102.00
IUUC-Cja-019274	Callithrix jacchus	82.29	3.00e-138	484.00
IUUC-Cfa-020461	Canis familiaris	80.56	1.00e-132	465.00
IUUC-Cpo-022251	Cavia porcellus	79.51	1.00e-135	475.00
IUUC-Csa-023112	Chlorocebus sabaeus	82.64	8.00e-131	459.00
IUUC-Cho-024504	Choloepus hoffmanni	55.71	2.00e-90	326.00
IUUC-Dre-028202	Danio rerio	56.55	3.00e-107	382.00
IUUC-Dor-030508	Dipodomys ordii	66.11	1.00e-119	422.00
IUUC-Dme-031980	Drosophila melanogaster	36.91	3.00e-61	229.00
IUUC-Ete-032281	Echinops telfairi	59.43	2.00e-64	239.00
IUUC-Eca-033228	Equus caballus	82.70	5.00e-138	483.00
IUUC-Fca-036045	Felis catus	62.65	5.00e-20	88.60
IUUC-Fal-037507	Ficedula albicollis	68.80	2.00e-140	492.00
IUUC-Gmo-038744	Gadus morhua	64.29	7.00e-64	237.00
IUUC-Gga-040353	Gallus gallus	67.69	2.00e-133	468.00
IUUC-Gac-042519	Gasterosteus aculeatus	48.36	8.00e-88	317.00
IUUC-Hsa-046016	Homo sapiens	80.39	2.00e-164	572.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	77.29	6.00e-150	523.00
IUUC-Loc-052389	Lepisosteus oculatus	61.26	2.00e-117	416.00
IUUC-Laf-053412	Loxodonta africana	54.44	6.00e-19	85.10
IUUC-Mcc-054933	Macaca mulatta	79.56	3.00e-163	568.00
IUUC-Meu-055963	Macropus eugenii	55.41	2.00e-85	309.00
IUUC-Mga-059626	Meleagris gallopavo	64.00	2.00e-19	86.70
IUUC-Mmr-061566	Microcebus murinus	72.88	7.00e-39	153.00
IUUC-Mdo-062933	Monodelphis domestica	64.86	4.00e-19	85.50
IUUC-Mmu-063561	Mus musculus	74.72	7.00e-151	526.00
IUUC-Mpu-065799	Mustela putorius furo	81.25	2.00e-131	461.00
IUUC-Nle-070078	Nomascus leucogenys	81.61	2.00e-141	494.00
IUUC-Opr-070541	Ochotona princeps	77.72	4.00e-152	531.00
IUUC-Ont-071743	Oreochromis niloticus	49.72	8.00e-89	320.00
IUUC-Oan-073700	Ornithorhynchus anatinus	87.04	1.00e-22	97.10
IUUC-Oga-088867	Otolemur garnettii	78.06	1.00e-156	545.00
IUUC-Oar-089365	Ovis aries	78.14	2.00e-159	554.00
IUUC-Ptr-091371	Pan troglodytes	80.39	8.00e-164	570.00
IUUC-Pan-092443	Papio anubis	82.64	3.00e-138	484.00
IUUC-Psi-093851	Pelodiscus sinensis	66.39	4.00e-90	324.00
IUUC-Pfo-097194	Poecilia formosa	48.88	3.00e-88	318.00
IUUC-Pab-097999	Pongo abelii	66.00	1.00e-117	415.00
IUUC-Pca-100410	Procavia capensis	75.77	9.00e-144	503.00
IUUC-Pva-102300	Pteropus vampyrus	70.75	3.00e-136	478.00
IUUC-Rno-105556	Rattus norvegicus	76.39	5.00e-129	453.00
IUUC-Sha-106992	Sarcophilus harrisii	90.74	7.00e-25	104.00
IUUC-Sar-113121	Sorex araneus	80.34	9.00e-48	184.00
IUUC-Ssc-116435	Sus scrofa	81.44	2.00e-133	468.00
IUUC-Tgu-117489	Taeniopygia guttata	68.89	2.00e-140	492.00
IUUC-Tru-117927	Takifugu rubripes	47.79	1.00e-93	337.00
IUUC-Tsy-119372	Tarsius syrichta	83.04	1.00e-105	376.00
IUUC-Tni-120043	Tetraodon nigroviridis	48.70	2.00e-82	299.00
IUUC-Tbe-127539	Tupaia belangeri	82.14	5.00e-147	514.00
IUUC-Ttr-129149	Tursiops truncatus	76.67	1.00e-153	536.00
IUUC-Vpa-130439	Vicugna pacos	60.61	5.00e-110	391.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence