iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054269

UUCD1 version

UUC-LoA-00700

Ensembl Protein ID

ENSLAFP00000018136.1

UniProt Accession

G3TRC8; G3TRC8_LOXAF

Protein Name

Uncharacterized protein

Gene Name

RBCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000027558.1	ENSLAFT00000027041.1	ENSLAFP00000018136.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	4.20e-11	42.5	196	221
ULD/UDP/UBQ/UBQ_Other	7.80e-06	26.0	59	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 4    qWaCsaCTflNePeavkCemCsrpRg 29
           +W+C+ CTf+N+P +++CemC+r R+
   Q: 196  GWQCPGCTFINKPTRPGCEMCCRARP 221
           8************************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlk..vnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglk 62
           v v++++ ++ t++  v p++t a LK +++   g+pp+ qr+++  ++ +d  tL ++g++
   Q: 59   VSVEDAQMRTVTIWltVRPDMTMASLKGHVFLDYGFPPALQRWVIGQRLTRDQETLHSHGVR 120
           67888888889999999****************************66666*********995 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MDGKNQKAEE MALSLSRAVA GGDEQVAMKC AIWLAERRVP LSVQLKPEFA PSQDIRLWVS 60
VEDAQMRTVT IWLTVRPDMT MASLKGHVFL DYGFPPALQR WVIGQRLTRD QETLHSHGVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGGGA AGAACCAGAA AGGTGGGCAC AGACGCGAGG CGGCTGGGGG ACTTCGGAGG 60
TGGGCCCCTC TCCCTCAAGG CCCCTCAAGG GTCTTCCCTC TGCTCATTTG TTCACTTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002867--IBR_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR027370--Znf-RING_LisH
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50053--UBIQUITIN_2
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR
PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00547--ZnF_RBZ

Gene Ontology

GO:0071797--C:LUBAC complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060546--P:negative regulation of necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001540	Ailuropoda melanoleuca	88.82	0.00e+00	836.00
IUUC-Apl-003627	Anas platyrhynchos	60.81	2.00e-19	86.70
IUUC-Aca-004507	Anolis carolinensis	64.76	4.00e-151	527.00
IUUC-Ame-011008	Astyanax mexicanus	51.38	3.00e-139	488.00
IUUC-Bta-013247	Bos taurus	90.59	0.00e+00	876.00
IUUC-Bci-013637	Botrytis cinerea	26.87	9.00e-14	72.40
IUUC-Cja-018880	Callithrix jacchus	90.59	0.00e+00	876.00
IUUC-Cfa-020477	Canis familiaris	90.20	0.00e+00	875.00
IUUC-Cpo-021558	Cavia porcellus	86.27	0.00e+00	827.00
IUUC-Csa-024129	Chlorocebus sabaeus	90.59	0.00e+00	840.00
IUUC-Cin-025630	Ciona intestinalis	39.95	8.00e-82	297.00
IUUC-Csv-026069	Ciona savignyi	50.00	6.00e-71	259.00
IUUC-Dre-027591	Danio rerio	51.85	8.00e-139	487.00
IUUC-Dno-029015	Dasypus novemcinctus	89.80	0.00e+00	846.00
IUUC-Dor-030313	Dipodomys ordii	78.69	0.00e+00	712.00
IUUC-Ete-032908	Echinops telfairi	79.80	0.00e+00	743.00
IUUC-Eca-034295	Equus caballus	73.96	0.00e+00	693.00
IUUC-Eeu-034454	Erinaceus europaeus	82.03	3.00e-109	388.00
IUUC-Fca-036380	Felis catus	91.76	0.00e+00	884.00
IUUC-Fal-037440	Ficedula albicollis	57.89	7.00e-16	74.70
IUUC-Gmo-038561	Gadus morhua	54.55	6.00e-120	424.00
IUUC-Gga-040198	Gallus gallus	40.82	1.00e-30	126.00
IUUC-Gac-041319	Gasterosteus aculeatus	51.96	1.00e-135	476.00
IUUC-Ggo-044456	Gorilla gorilla	63.97	1.00e-147	516.00
IUUC-Hsa-045738	Homo sapiens	91.76	0.00e+00	840.00
IUUC-Itr-049042	Ictidomys tridecemlineatus	88.04	0.00e+00	827.00
IUUC-Lch-050269	Latimeria chalumnae	43.98	2.00e-111	396.00
IUUC-Loc-052776	Lepisosteus oculatus	62.34	3.00e-107	382.00
IUUC-Mcc-055669	Macaca mulatta	91.37	0.00e+00	854.00
IUUC-Meu-055912	Macropus eugenii	50.00	5.00e-22	98.20
IUUC-Mga-059615	Meleagris gallopavo	54.69	8.00e-17	77.80
IUUC-Mmr-061562	Microcebus murinus	90.73	0.00e+00	754.00
IUUC-Mdo-062263	Monodelphis domestica	75.97	0.00e+00	727.00
IUUC-Mmu-064325	Mus musculus	87.65	0.00e+00	819.00
IUUC-Mpu-066385	Mustela putorius furo	90.20	0.00e+00	871.00
IUUC-Mlu-067000	Myotis lucifugus	88.95	0.00e+00	837.00
IUUC-Nle-069812	Nomascus leucogenys	91.18	0.00e+00	847.00
IUUC-Opr-070575	Ochotona princeps	92.65	1.00e-106	379.00
IUUC-Ont-072405	Oreochromis niloticus	50.00	8.00e-134	470.00
IUUC-Ocu-074358	Oryctolagus cuniculus	77.93	0.00e+00	737.00
IUUC-Ola-086403	Oryzias latipes	52.17	4.00e-135	474.00
IUUC-Oga-087986	Otolemur garnettii	88.63	0.00e+00	812.00
IUUC-Oar-089600	Ovis aries	88.04	0.00e+00	867.00
IUUC-Ptr-091224	Pan troglodytes	91.57	0.00e+00	838.00
IUUC-Pan-092739	Papio anubis	91.57	0.00e+00	856.00
IUUC-Pma-094407	Petromyzon marinus	47.76	2.00e-124	438.00
IUUC-Pfo-097161	Poecilia formosa	52.03	8.00e-130	457.00
IUUC-Pab-098627	Pongo abelii	91.57	0.00e+00	833.00
IUUC-Pca-100641	Procavia capensis	92.45	0.00e+00	823.00
IUUC-Pva-102670	Pteropus vampyrus	88.04	0.00e+00	839.00
IUUC-Pte-104234	Pyrenophora teres	25.97	2.00e-12	66.60
IUUC-Rno-105504	Rattus norvegicus	86.86	0.00e+00	811.00
IUUC-Sha-107342	Sarcophilus harrisii	75.39	0.00e+00	748.00
IUUC-Ssl-108588	Sclerotinia sclerotiorum	30.56	2.20e-02	33.50
IUUC-Sar-113425	Sorex araneus	86.76	4.00e-112	397.00
IUUC-Ssc-115904	Sus scrofa	90.75	5.00e-88	316.00
IUUC-Tru-118096	Takifugu rubripes	51.53	6.00e-137	480.00
IUUC-Tni-119873	Tetraodon nigroviridis	49.32	1.00e-135	476.00
IUUC-Tbe-127578	Tupaia belangeri	88.65	0.00e+00	677.00
IUUC-Ttr-129107	Tursiops truncatus	89.80	0.00e+00	825.00
IUUC-Vpa-130353	Vicugna pacos	92.31	1.00e-119	422.00
IUUC-Xtr-132168	Xenopus tropicalis	42.41	8.00e-94	337.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence