iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118287

UUCD1 version

UUC-TaR-00173

Ensembl Protein ID

ENSTRUP00000009255.1

UniProt Accession

H2SA29; H2SA29_TAKRU

Protein Name

E3 ubiquitin-protein ligase

Gene Name

wwp2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000003922.1	ENSTRUT00000009310.1	ENSTRUP00000009255.1
ENSTRUG00000003922.1	ENSTRUT00000009311.1	ENSTRUP00000009256.1
ENSTRUG00000003922.1	ENSTRUT00000009312.1	ENSTRUP00000009257.1
ENSTRUG00000003922.1	ENSTRUT00000009313.1	ENSTRUP00000009258.1
ENSTRUG00000003922.1	ENSTRUT00000009314.1	ENSTRUP00000009259.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-132	442.3	596	928

Active Site

Position(s)	Description	Evidence
897	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 596  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 683
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l+dle++dpe+y+s++++ken   ++ee+g++l f ++ eilg+++++eLk+gGen+ Vt+eNkeeY++l+++
   Q: 684  GFTLPFYKQMLDKKPTLKDLESIDPEFYNSIMWVKEN---NLEECGVELFFAQDMEILGKVSSHELKEGGENELVTEENKEEYISLLTN 769
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g+keq+ af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++i+wFw+v++e+++e+r ++LqFv
   Q: 770  WRFTRGVKEQTRAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLSDWQKNTIYRH-YTKNSKQIHWFWQVVKEMDNEKRIRLLQFV 857
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf el     p++f+i k +++++lP+s+TCfn+L+LP+Y s e+l+ekL++Aieet+gF++
   Q: 858  TGTCRLPVGGFSELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYRSLEQLREKLMFAIEETEGFGQ 928
           *********************************************************************96 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MAAASVSRPG SAQTTEKSQL ILKVVSAKPQ SPRPPNRYSR LSSFVEVTAD GLTSETKKTG 60
KRSGHLELQW NEDLTLNVTP QSRLDLKLWS CHTLKKELLG SATIDLLDTL RTHDGKMENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGTTCACT AGCGACAGCG GAGCACAGCT GAAAAGGTAC GGCAAAGGCT ACATTTTAGA 60
AAAAAATGTT CTGTTTCAAT GGATATGGGA TGTTCTGACA CGTATTTTGT ATCTAACAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	88.97	0.00e+00	1100.00
IUUC-Aca-004291	Anolis carolinensis	90.69	0.00e+00	1120.00
IUUC-Bta-013231	Bos taurus	89.46	0.00e+00	1104.00
IUUC-Cja-019455	Callithrix jacchus	89.63	0.00e+00	1102.00
IUUC-Cfa-021017	Canis familiaris	89.98	0.00e+00	1109.00
IUUC-Cpo-021988	Cavia porcellus	89.63	0.00e+00	1110.00
IUUC-Csa-023549	Chlorocebus sabaeus	89.28	0.00e+00	1106.00
IUUC-Dre-028513	Danio rerio	93.32	0.00e+00	1155.00
IUUC-Dno-028976	Dasypus novemcinctus	89.81	0.00e+00	1110.00
IUUC-Dor-030176	Dipodomys ordii	89.98	0.00e+00	1103.00
IUUC-Eca-033949	Equus caballus	89.46	0.00e+00	1108.00
IUUC-Eeu-034529	Erinaceus europaeus	89.38	0.00e+00	932.00
IUUC-Fca-036236	Felis catus	89.63	0.00e+00	1109.00
IUUC-Fal-036948	Ficedula albicollis	90.86	0.00e+00	1114.00
IUUC-Gmo-038842	Gadus morhua	91.75	0.00e+00	1090.00
IUUC-Gga-040617	Gallus gallus	91.21	0.00e+00	1127.00
IUUC-Gac-041338	Gasterosteus aculeatus	93.68	0.00e+00	1107.00
IUUC-Ggo-045278	Gorilla gorilla	89.81	0.00e+00	1109.00
IUUC-Hsa-046148	Homo sapiens	89.81	0.00e+00	1109.00
IUUC-Lch-050663	Latimeria chalumnae	91.39	0.00e+00	1130.00
IUUC-Loc-052604	Lepisosteus oculatus	91.24	0.00e+00	1113.00
IUUC-Laf-053944	Loxodonta africana	89.63	0.00e+00	1108.00
IUUC-Mcc-055655	Macaca mulatta	89.28	0.00e+00	1107.00
IUUC-Meu-055953	Macropus eugenii	78.73	0.00e+00	950.00
IUUC-Mga-060190	Meleagris gallopavo	91.21	0.00e+00	1129.00
IUUC-Mmr-060896	Microcebus murinus	89.63	0.00e+00	1110.00
IUUC-Mdo-062536	Monodelphis domestica	90.33	0.00e+00	1118.00
IUUC-Mmu-064017	Mus musculus	89.63	0.00e+00	1110.00
IUUC-Mpu-066608	Mustela putorius furo	86.49	0.00e+00	1063.00
IUUC-Mlu-067623	Myotis lucifugus	86.49	0.00e+00	1058.00
IUUC-Nle-069496	Nomascus leucogenys	86.82	0.00e+00	1064.00
IUUC-Opr-071054	Ochotona princeps	89.10	0.00e+00	1094.00
IUUC-Ont-071279	Oreochromis niloticus	81.59	0.00e+00	1431.00
IUUC-Oan-073512	Ornithorhynchus anatinus	86.97	0.00e+00	1078.00
IUUC-Ocu-074271	Oryctolagus cuniculus	88.93	0.00e+00	1103.00
IUUC-Ola-087237	Oryzias latipes	93.86	0.00e+00	1093.00
IUUC-Oga-088164	Otolemur garnettii	89.46	0.00e+00	1106.00
IUUC-Oar-089698	Ovis aries	89.46	0.00e+00	1103.00
IUUC-Ptr-091306	Pan troglodytes	88.22	0.00e+00	1082.00
IUUC-Pan-092814	Papio anubis	87.87	0.00e+00	1081.00
IUUC-Pfo-096709	Poecilia formosa	77.28	0.00e+00	1335.00
IUUC-Pab-098494	Pongo abelii	89.63	0.00e+00	1108.00
IUUC-Pca-100596	Procavia capensis	90.15	0.00e+00	932.00
IUUC-Pva-103154	Pteropus vampyrus	89.81	0.00e+00	1049.00
IUUC-Rno-104954	Rattus norvegicus	89.10	0.00e+00	1100.00
IUUC-Sha-106781	Sarcophilus harrisii	89.81	0.00e+00	1114.00
IUUC-Ssc-116307	Sus scrofa	84.59	0.00e+00	1030.00
IUUC-Tni-120801	Tetraodon nigroviridis	85.11	0.00e+00	1177.00
IUUC-Tbe-127793	Tupaia belangeri	79.44	0.00e+00	951.00
IUUC-Ttr-128275	Tursiops truncatus	89.46	0.00e+00	1107.00
IUUC-Xtr-132866	Xenopus tropicalis	87.19	0.00e+00	1080.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence