iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045811

UUCD1 version

UUC-HoS-00078

Ensembl Protein ID

ENSP00000381981.2

UniProt Accession

P53804; A8K7H7; B2RPA7; D3DSG9; D3DSH2; D3DSH3; O60767; P78476; P78477; Q569I2; Q6P578; Q9UEK4; TTC3_HUMAN

Genbank Protein ID

BAA11769.1; BAA12301.1; BAA12302.1; BAA12303.1; EAX09716.1; EAX09717.1; EAX09718.1; EAX09719.1; EAX09720.1; EAX09721.1; EAX09722.1; EAX09723.1; AAH63033.1; AAH92466.1; AAI37346.1; BAF84681.1; BAA23666.1; CAA05057.1

Protein Name

E3 ubiquitin-protein ligase TTC3; Protein DCRR1; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3; TPR repeat protein D; Tetratricopeptide repeat protein 3

Genbank Nucleotide ID

D83077; D84294; D84295; D84296; AP001429; CH471079; CH471079; CH471079; CH471079; CH471079; CH471079; CH471079; BC063033; BC092466; BC137345; AK291992; D83327; AJ001866

Gene Name

TTC3; DCRR1; RNF105; TPRD

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000182670.13	ENST00000438055.5	ENSP00000391891.1
ENSG00000182670.13	ENST00000540756.5	ENSP00000442875.1
ENSG00000182670.13	ENST00000399010.5	ENSP00000381974.1
ENSG00000182670.13	ENST00000399017.6	ENSP00000381981.2
ENSG00000182670.13	ENST00000414818.1	ENSP00000414658.1
ENSG00000182670.13	ENST00000411496.1	ENSP00000387880.1
ENSG00000182670.13	ENST00000428693.1	ENSP00000393681.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20059946; 20059950; 20059946

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	3.80e-07	32.2	1957	1997

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e f  k+ ++vl CgH +h+ C+++w       +++  CP C+
   Q: 1957 CEICHEVFksKN-VRVLKCGHKYHKGCFKQW------LKGQSACPACQ 1997
           99****998566.******************......**********7 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.

Protein Sequence
(Fasta)

MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV QYKDYIQSER 60
NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS SVISRLHPCV DANNSRASEI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGTGACGCA CCTCGCTTCA ACGCCGCCAC CCGCTCCCTC CCGCCGTCGG CTGACGTGGA 60
GGGCCGGAGG TGGCGGCGGC GGCGGCGGCG GCTGCTGCTG CTGCTGCCCG CGTCCGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011029--DEATH-like_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50005--TPR
PS50293--TPR_REGION
PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING
SM00028--TPR

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0070936--P:protein K48-linked ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7267

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002231	Ailuropoda melanoleuca	94.44	7.00e-28	114.00
IUUC-Apl-003622	Anas platyrhynchos	49.19	0.00e+00	1046.00
IUUC-Aca-004579	Anolis carolinensis	36.13	2.00e-60	226.00
IUUC-Ame-011167	Astyanax mexicanus	38.78	8.00e-170	592.00
IUUC-Bta-012916	Bos taurus	80.25	0.00e+00	2950.00
IUUC-Cja-019100	Callithrix jacchus	90.22	0.00e+00	3331.00
IUUC-Cfa-020974	Canis familiaris	83.09	0.00e+00	3168.00
IUUC-Cpo-022435	Cavia porcellus	65.70	0.00e+00	1842.00
IUUC-Csa-023245	Chlorocebus sabaeus	91.95	0.00e+00	3531.00
IUUC-Cho-024822	Choloepus hoffmanni	64.63	0.00e+00	1257.00
IUUC-Cin-025626	Ciona intestinalis	30.68	5.00e-19	89.00
IUUC-Dre-027805	Danio rerio	35.58	2.00e-105	378.00
IUUC-Dno-029413	Dasypus novemcinctus	65.38	0.00e+00	2335.00
IUUC-Dor-030670	Dipodomys ordii	81.11	0.00e+00	1538.00
IUUC-Ete-032367	Echinops telfairi	39.97	1.00e-109	392.00
IUUC-Eca-033891	Equus caballus	82.84	0.00e+00	3138.00
IUUC-Fca-035889	Felis catus	81.33	0.00e+00	3037.00
IUUC-Fal-037399	Ficedula albicollis	42.86	0.00e+00	894.00
IUUC-Gga-040490	Gallus gallus	47.09	0.00e+00	977.00
IUUC-Ggo-045441	Gorilla gorilla	93.45	0.00e+00	3502.00
IUUC-Itr-048367	Ictidomys tridecemlineatus	82.43	0.00e+00	942.00
IUUC-Lch-049809	Latimeria chalumnae	41.32	3.00e-127	449.00
IUUC-Loc-052533	Lepisosteus oculatus	33.82	0.00e+00	727.00
IUUC-Laf-053785	Loxodonta africana	66.81	0.00e+00	1531.00
IUUC-Mcc-054801	Macaca mulatta	95.07	0.00e+00	3625.00
IUUC-Mga-059963	Meleagris gallopavo	47.58	0.00e+00	1029.00
IUUC-Mmr-060707	Microcebus murinus	83.65	0.00e+00	3093.00
IUUC-Mdo-062718	Monodelphis domestica	49.37	0.00e+00	1259.00
IUUC-Mmu-064257	Mus musculus	75.91	0.00e+00	2761.00
IUUC-Mpu-066020	Mustela putorius furo	82.07	0.00e+00	3100.00
IUUC-Mlu-067023	Myotis lucifugus	77.47	0.00e+00	2860.00
IUUC-Nle-069965	Nomascus leucogenys	96.40	0.00e+00	3686.00
IUUC-Opr-070629	Ochotona princeps	63.99	0.00e+00	962.00
IUUC-Ont-072604	Oreochromis niloticus	34.37	3.00e-154	540.00
IUUC-Oan-072830	Ornithorhynchus anatinus	48.11	0.00e+00	1506.00
IUUC-Ocu-073774	Oryctolagus cuniculus	81.33	0.00e+00	2974.00
IUUC-Ola-086847	Oryzias latipes	35.94	1.00e-145	511.00
IUUC-Oga-088372	Otolemur garnettii	82.58	0.00e+00	2306.00
IUUC-Oar-090039	Ovis aries	78.80	0.00e+00	2931.00
IUUC-Ptr-091171	Pan troglodytes	98.77	0.00e+00	3813.00
IUUC-Pan-091926	Papio anubis	91.85	0.00e+00	3631.00
IUUC-Psi-093680	Pelodiscus sinensis	49.75	0.00e+00	1054.00
IUUC-Pab-098120	Pongo abelii	97.28	0.00e+00	3759.00
IUUC-Pva-102424	Pteropus vampyrus	75.59	0.00e+00	1660.00
IUUC-Pte-104037	Pyrenophora teres	27.94	6.00e-07	48.50
IUUC-Pyt-104680	Pyrenophora triticirepentis	34.43	1.00e-07	50.80
IUUC-Rno-105101	Rattus norvegicus	75.32	0.00e+00	2776.00
IUUC-Sha-106607	Sarcophilus harrisii	62.23	0.00e+00	915.00
IUUC-Sar-113589	Sorex araneus	73.05	0.00e+00	2118.00
IUUC-Ssc-115530	Sus scrofa	85.76	0.00e+00	2506.00
IUUC-Tgu-116671	Taeniopygia guttata	43.96	0.00e+00	798.00
IUUC-Tru-118283	Takifugu rubripes	33.84	5.00e-139	488.00
IUUC-Tsy-118872	Tarsius syrichta	78.72	0.00e+00	2172.00
IUUC-Tbe-127996	Tupaia belangeri	75.98	0.00e+00	1798.00
IUUC-Ttr-128379	Tursiops truncatus	82.26	0.00e+00	2967.00
IUUC-Vpa-130372	Vicugna pacos	79.30	0.00e+00	2526.00
IUUC-Xtr-132649	Xenopus tropicalis	36.76	0.00e+00	684.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence