• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046510
UUCD1 version UUC-HoS-00723
Ensembl Protein ID ENSP00000242810.6
UniProt Accession Q6TFL4; A5PLN8; Q9H620; Q9NXT9; KLH24_HUMAN
Genbank Protein ID AAR13703.1; ABI96896.1; BAA90921.1; BAB15447.1; CAI46031.1; CAI46002.1; AAI42994.1
Protein Name Kelch-like protein 24; Kainate receptor-interacting protein for GluR6; Protein DRE1
Genbank Nucleotide ID AY422472; DQ925701; AK000066; AK026326; BX648466; BX648812; BC142993
Gene Name KLHL24; DRE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000114796.15 ENST00000242810.10 ENSP00000242810.6
ENSG00000114796.15 ENST00000476808.1 ENSP00000419010.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 4.70e-21 76.6 66 131
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 6.80e-07 28.6 167 195
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dvi++v+g+ef++h++vL+a+Ss+F+a+f ++ +es+ +  vei+++ +e+++ +l+++Ytgk+++
   Q: 66   TDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESR-EMLVEINGILAEAMECFLQYVYTGKVKI 131
           7************************************9.999**********************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 3    NclgilrfAdlydcpdLkdaaldfilkhF 31
           Nclgi rfAd++++  L  ++ +f+l+ F
   Q: 167  NCLGIQRFADTHSLKTLFTKCKNFALQTF 195
           *************************9977 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.
 Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.
Protein Sequence
(Fasta)
MVLILGRRLN REDLGVRDSP ATKRKVFEMD PKSLTGHEFF DFSSGSSHAE NILQIFNEFR 60
DSRLFTDVII CVEGKEFPCH RAVLSACSSY FRAMFCNDHR ESREMLVEIN GILAEAMECF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046510|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCAGGGTT CGCTGACGCT CAGTGTTTTG GCCCGGACGG TCACATGTTT CCTTTGTTGT 60
GAGCTGCGGC AGAGACTGGT GGCTGGAGGA GACGCCGGCG CTGGAGAGTG CGCTGCGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046510|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030596--KLHL24
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0030424--C:axon
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0043204--C:perikaryon
GO:0016567--P:protein ubiquitination
GO:2000312--P:regulation of kainate selective glutamate receptor activity
KEGG hsa:54800
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001447 Ailuropoda melanoleuca 99.50 0.00e+00 1212.00
IUUC-Aca-004821 Anolis carolinensis 95.00 0.00e+00 1165.00
IUUC-Ame-010778 Astyanax mexicanus 84.97 0.00e+00 1094.00
IUUC-Bta-012622 Bos taurus 99.34 0.00e+00 1208.00
IUUC-Cja-018938 Callithrix jacchus 99.83 0.00e+00 1218.00
IUUC-Cfa-020831 Canis familiaris 99.83 0.00e+00 1217.00
IUUC-Cpo-021569 Cavia porcellus 98.83 0.00e+00 1205.00
IUUC-Csa-024070 Chlorocebus sabaeus 100.00 0.00e+00 1220.00
IUUC-Cin-025465 Ciona intestinalis 53.38 0.00e+00 648.00
IUUC-Csv-025878 Ciona savignyi 54.01 0.00e+00 636.00
IUUC-Dre-028103 Danio rerio 85.28 0.00e+00 1090.00
IUUC-Dno-029374 Dasypus novemcinctus 98.84 0.00e+00 1203.00
IUUC-Dor-030922 Dipodomys ordii 86.01 3.00e-143 502.00
IUUC-Dse-031370 Dothistroma septosporum 36.36 1.00e-05 43.50
IUUC-Ete-032909 Echinops telfairi 98.00 0.00e+00 1185.00
IUUC-Eca-034390 Equus caballus 99.50 0.00e+00 1213.00
IUUC-Fca-036449 Felis catus 99.67 0.00e+00 1214.00
IUUC-Fal-036612 Ficedula albicollis 96.83 0.00e+00 1185.00
IUUC-Gmo-038760 Gadus morhua 81.47 0.00e+00 1035.00
IUUC-Gga-040779 Gallus gallus 96.75 0.00e+00 744.00
IUUC-Gac-042145 Gasterosteus aculeatus 82.72 0.00e+00 1061.00
IUUC-Ggo-045506 Gorilla gorilla 99.50 0.00e+00 1212.00
IUUC-Itr-048255 Ictidomys tridecemlineatus 99.34 0.00e+00 1210.00
IUUC-Lch-049594 Latimeria chalumnae 86.91 0.00e+00 1099.00
IUUC-Loc-052147 Lepisosteus oculatus 86.62 0.00e+00 1090.00
IUUC-Laf-054224 Loxodonta africana 99.00 0.00e+00 1204.00
IUUC-Meu-056366 Macropus eugenii 97.46 8.00e-159 553.00
IUUC-Mga-059535 Meleagris gallopavo 96.67 0.00e+00 1168.00
IUUC-Mdo-063082 Monodelphis domestica 97.17 0.00e+00 1186.00
IUUC-Mmu-063152 Mus musculus 99.33 0.00e+00 1216.00
IUUC-Mpu-065928 Mustela putorius furo 99.83 0.00e+00 1217.00
IUUC-Mlu-068041 Myotis lucifugus 98.84 0.00e+00 1204.00
IUUC-Nle-069293 Nomascus leucogenys 100.00 0.00e+00 1220.00
IUUC-Opr-070368 Ochotona princeps 99.50 0.00e+00 1215.00
IUUC-Ont-071571 Oreochromis niloticus 82.30 0.00e+00 1035.00
IUUC-Oan-072849 Ornithorhynchus anatinus 97.50 0.00e+00 1192.00
IUUC-Ocu-073987 Oryctolagus cuniculus 99.34 0.00e+00 1210.00
IUUC-Ola-087513 Oryzias latipes 81.30 0.00e+00 1053.00
IUUC-Oga-088595 Otolemur garnettii 99.50 0.00e+00 1212.00
IUUC-Oar-089935 Ovis aries 99.34 0.00e+00 1208.00
IUUC-Ptr-091664 Pan troglodytes 99.67 0.00e+00 1209.00
IUUC-Pan-091881 Papio anubis 99.67 0.00e+00 1214.00
IUUC-Psi-092983 Pelodiscus sinensis 96.67 0.00e+00 1184.00
IUUC-Pfo-096218 Poecilia formosa 77.01 0.00e+00 985.00
IUUC-Pab-098487 Pongo abelii 100.00 0.00e+00 1220.00
IUUC-Pca-100916 Procavia capensis 98.33 0.00e+00 1198.00
IUUC-Pva-103010 Pteropus vampyrus 99.50 0.00e+00 1212.00
IUUC-Rno-105025 Rattus norvegicus 99.00 0.00e+00 1206.00
IUUC-Sha-106793 Sarcophilus harrisii 97.83 0.00e+00 1191.00
IUUC-Sar-113290 Sorex araneus 88.67 0.00e+00 1078.00
IUUC-Ssc-115631 Sus scrofa 99.34 0.00e+00 1209.00
IUUC-Tgu-116856 Taeniopygia guttata 97.00 0.00e+00 1188.00
IUUC-Tru-118210 Takifugu rubripes 82.17 0.00e+00 1030.00
IUUC-Tsy-118964 Tarsius syrichta 99.67 0.00e+00 632.00
IUUC-Tni-120462 Tetraodon nigroviridis 82.21 0.00e+00 1026.00
IUUC-Tbe-128114 Tupaia belangeri 98.69 6.00e-178 617.00
IUUC-Ttr-128565 Tursiops truncatus 99.33 0.00e+00 1211.00
IUUC-Vpa-130093 Vicugna pacos 89.50 0.00e+00 1071.00
IUUC-Xtr-132233 Xenopus tropicalis 90.83 0.00e+00 1127.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved