iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054428

UUCD1 version

UUC-LoA-01078

Ensembl Protein ID

ENSLAFP00000008187.3

UniProt Accession

G3T4B5; G3T4B5_LOXAF

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000009765.3	ENSLAFT00000009767.3	ENSLAFP00000008187.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.50e-112	374.0	145	681

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk.....eknkpkeeeeeedkselsde........................................... 129
           qqD+qEfl++l+dql+eelk+       +  + e++++d+s+++d+                                           
   Q: 229  QQDTQEFLRCLMDQLHEELKEpevaaAVTAAVAEARDSDSSDTDDKregdrspsedeflscdsssdrgegdgqgrggggsqaetellip 317
           *******************99999985566666666666666666677777777788******************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 318  deagraisekermkdrkfswgqqrtnseqvdedadvdtamaaldeqstetlppsprsaspcrtpepdndaqmcsssrpcspvhklsstp 406
           ***************************************************************************************** PP
   S: 130  .......................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......... 185
                                  ++++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+          
   Q: 407  praspvrmgpsyvlkkaqvltsgSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiyqnvpa 495
           **************************************************************************99888********** PP
   S: 186  .......................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLk 235
                                                  +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L++hLk
   Q: 496  kpgtcgdsyaaqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 584
           ***************************************************************************************** PP
   S: 236  Rfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeev 322
           Rf  ++e + + kin++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e+ v
   Q: 585  RF--RHEVMYSFKINNHVSFPLEgLDLRPFLAKECMSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHETVV 669
           **..9999*************************99998..9**************************78999***************** PP
   S: 323  leetgstaYvlfYkr 337
           ++   ++aYvlfY++
   Q: 670  QN---AEAYVLFYRK 681
           **...********98 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MGDSRDLCPH LDSIGEVTKE DLLLKAKGTC QSCGVAGPNL WACLQIACPY VGCGESFDDH 60
STIHAQVKKH NLTVNLTTFR VWCYACEKEV FLEQRLVAPP PAPSPKFSEQ DSPPPSHPLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGACT CCAGGGACCT GTGCCCTCAC CTTGACTCCA TAGGGGAGGT GACCAAAGAG 60
GATTTGCTGC TCAAAGCTAA GGTAAAGGGG GCGAGGCACA CACCAGGGCC ATGTTGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lav:100663684

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	91.38	0.00e+00	1631.00
IUUC-Apl-003351	Anas platyrhynchos	85.67	0.00e+00	1555.00
IUUC-Aca-005077	Anolis carolinensis	76.97	0.00e+00	1098.00
IUUC-Ame-011777	Astyanax mexicanus	74.14	0.00e+00	1332.00
IUUC-Bta-013063	Bos taurus	92.58	0.00e+00	1620.00
IUUC-Cja-019868	Callithrix jacchus	92.92	0.00e+00	1683.00
IUUC-Cfa-020761	Canis familiaris	92.15	0.00e+00	1658.00
IUUC-Cpo-022267	Cavia porcellus	85.20	0.00e+00	1508.00
IUUC-Csa-024251	Chlorocebus sabaeus	93.46	0.00e+00	1692.00
IUUC-Cho-024483	Choloepus hoffmanni	97.17	3.00e-125	442.00
IUUC-Csv-025889	Ciona savignyi	43.75	1.00e-35	142.00
IUUC-Dre-028061	Danio rerio	74.56	0.00e+00	1210.00
IUUC-Dno-029423	Dasypus novemcinctus	94.55	0.00e+00	1669.00
IUUC-Dor-030877	Dipodomys ordii	91.17	0.00e+00	1083.00
IUUC-Dme-031837	Drosophila melanogaster	43.59	7.00e-137	481.00
IUUC-Ete-032802	Echinops telfairi	80.74	3.00e-136	479.00
IUUC-Eca-034283	Equus caballus	91.93	0.00e+00	1654.00
IUUC-Eeu-034620	Erinaceus europaeus	88.19	0.00e+00	1135.00
IUUC-Fca-036357	Felis catus	92.80	0.00e+00	1631.00
IUUC-Fal-037411	Ficedula albicollis	86.09	0.00e+00	1557.00
IUUC-Gga-041101	Gallus gallus	85.70	0.00e+00	1536.00
IUUC-Gac-041315	Gasterosteus aculeatus	72.19	0.00e+00	1314.00
IUUC-Ggo-045600	Gorilla gorilla	92.84	0.00e+00	1634.00
IUUC-Hsa-045825	Homo sapiens	93.46	0.00e+00	1649.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	79.89	0.00e+00	1363.00
IUUC-Lch-050002	Latimeria chalumnae	75.27	0.00e+00	1310.00
IUUC-Loc-052574	Lepisosteus oculatus	78.16	0.00e+00	1418.00
IUUC-Mcc-055736	Macaca mulatta	93.24	0.00e+00	1689.00
IUUC-Mga-059781	Meleagris gallopavo	85.05	0.00e+00	1536.00
IUUC-Mdo-063048	Monodelphis domestica	87.16	0.00e+00	1530.00
IUUC-Mmu-064079	Mus musculus	89.87	0.00e+00	1632.00
IUUC-Mpu-066616	Mustela putorius furo	91.40	0.00e+00	1670.00
IUUC-Mlu-067294	Myotis lucifugus	90.29	0.00e+00	1559.00
IUUC-Nle-070015	Nomascus leucogenys	93.35	0.00e+00	1617.00
IUUC-Opr-070328	Ochotona princeps	91.62	0.00e+00	1647.00
IUUC-Ont-071464	Oreochromis niloticus	75.99	0.00e+00	935.00
IUUC-Oan-073259	Ornithorhynchus anatinus	79.25	0.00e+00	1309.00
IUUC-Ocu-074630	Oryctolagus cuniculus	89.75	0.00e+00	1569.00
IUUC-Ola-087240	Oryzias latipes	74.03	0.00e+00	1299.00
IUUC-Oga-088761	Otolemur garnettii	92.03	0.00e+00	1661.00
IUUC-Oar-089490	Ovis aries	87.13	0.00e+00	1472.00
IUUC-Ptr-091662	Pan troglodytes	93.57	0.00e+00	1649.00
IUUC-Pan-092199	Papio anubis	93.04	0.00e+00	1682.00
IUUC-Psi-093726	Pelodiscus sinensis	87.04	0.00e+00	1569.00
IUUC-Pma-094389	Petromyzon marinus	63.88	3.00e-99	354.00
IUUC-Pab-098632	Pongo abelii	93.57	0.00e+00	1649.00
IUUC-Pca-100614	Procavia capensis	88.51	0.00e+00	1308.00
IUUC-Pva-102922	Pteropus vampyrus	88.51	0.00e+00	928.00
IUUC-Rno-105215	Rattus norvegicus	89.64	0.00e+00	1629.00
IUUC-Sce-106176	Saccharomyces cerevisiae	32.97	7.00e-26	112.00
IUUC-Sha-106601	Sarcophilus harrisii	85.85	0.00e+00	1502.00
IUUC-Ssc-115533	Sus scrofa	91.27	0.00e+00	1618.00
IUUC-Tgu-117364	Taeniopygia guttata	86.37	0.00e+00	1523.00
IUUC-Tru-117770	Takifugu rubripes	72.19	0.00e+00	1308.00
IUUC-Tni-120001	Tetraodon nigroviridis	72.78	0.00e+00	1278.00
IUUC-Ttr-128732	Tursiops truncatus	93.46	0.00e+00	1644.00
IUUC-Xtr-132157	Xenopus tropicalis	76.61	0.00e+00	1361.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence