iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048744

Ensembl Protein ID

ENSSTOP00000018787.1

UniProt Accession

I3N341; I3N341_ICTTR

Genbank Protein ID

ENSSTOP00000018787

Protein Name

E3 ubiquitin-protein ligase parkin

Genbank Nucleotide ID

AGTP01022075

Gene Name

PARK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000021965.1	ENSSTOT00000020833.1	ENSSTOP00000018787.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.50e-22	79.3	1	72

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 3    ltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkks 74
           ++v++++++ f++ev++d+++ +lKe +ak++gvp+ q+++I+aGk+L++d t+++++++++s+vh+v++++
   Q: 1    VFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPAGQLRVIFAGKELQNDLTVQNCDLEQQSIVHIVQRPR 72
           789**99999**********************************************************9986 PP

Organism

Ictidomys tridecemlineatus

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

VFVRFNSSHG FPVEVDSDTS IFQLKEVVAK RQGVPAGQLR VIFAGKELQN DLTVQNCDLE 60
QQSIVHIVQR PRRGPEADAP GGDEPRTVLG GPEREPRSLT RVDLSSSVLP ADSVGLAVVL 120

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Nucleotide Sequence
(Fasta)

GTGTTTGTCA GATTCAACTC CAGCCACGGT TTCCCTGTGG AGGTCGATTC TGACACCAGC 60
ATCTTCCAGC TCAAGGAAGT GGTTGCTAAG CGACAGGGGG TTCCAGCTGG CCAGCTGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0071797--C:LUBAC complex
GO:0005739--C:mitochondrion
GO:0099073--C:mitochondrion-derived vesicle
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0043234--C:protein complex
GO:0046872--F:metal ion binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008344--P:adult locomotory behavior
GO:0070842--P:aggresome assembly
GO:0097237--P:cellular response to toxic substance
GO:0042417--P:dopamine metabolic process
GO:0051583--P:dopamine uptake involved in synaptic transmission
GO:0010994--P:free ubiquitin chain polymerization
GO:0007612--P:learning
GO:0000423--P:macromitophagy
GO:0099074--P:mitochondrion to lysosome transport
GO:0044828--P:negative regulation by host of viral genome replication
GO:0032232--P:negative regulation of actin filament bundle assembly
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:1903382--P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542--P:negative regulation of exosomal secretion
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion
GO:1905366--P:negative regulation of intralumenal vesicle formation
GO:1902254--P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1903377--P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1902283--P:negative regulation of primary amine oxidase activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:1904049--P:negative regulation of spontaneous neurotransmitter secretion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042415--P:norepinephrine metabolic process
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:0043388--P:positive regulation of DNA binding
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010636--P:positive regulation of mitochondrial fusion
GO:0051582--P:positive regulation of neurotransmitter uptake
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:1902530--P:positive regulation of protein linear polyubiquitination
GO:1905477--P:positive regulation of protein localization to membrane
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0050821--P:protein stabilization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042053--P:regulation of dopamine metabolic process
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0034976--P:response to endoplasmic reticulum stress
GO:0001964--P:startle response
GO:0035249--P:synaptic transmission, glutamatergic

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	82.58	2.00e-138	484.00
IUUC-Apl-003304	Anas platyrhynchos	77.06	3.00e-154	536.00
IUUC-Aca-004908	Anolis carolinensis	76.85	5.00e-48	181.00
IUUC-Ame-011856	Astyanax mexicanus	61.24	1.00e-161	562.00
IUUC-Bta-013014	Bos taurus	81.46	0.00e+00	654.00
IUUC-Cel-018687	Caenorhabditis elegans	29.06	2.00e-36	146.00
IUUC-Cja-019274	Callithrix jacchus	85.07	9.00e-142	495.00
IUUC-Cfa-020461	Canis familiaris	80.14	4.00e-136	476.00
IUUC-Cpo-022251	Cavia porcellus	85.42	3.00e-144	503.00
IUUC-Csa-023112	Chlorocebus sabaeus	84.03	1.00e-131	461.00
IUUC-Cho-024504	Choloepus hoffmanni	58.87	4.00e-138	484.00
IUUC-Cgl-026479	Colletotrichum gloeosporioides	52.94	4.00e-11	63.20
IUUC-Dre-028202	Danio rerio	61.47	1.00e-152	532.00
IUUC-Dno-028946	Dasypus novemcinctus	68.57	9.00e-40	154.00
IUUC-Dor-030508	Dipodomys ordii	69.08	5.00e-130	457.00
IUUC-Dme-031980	Drosophila melanogaster	41.56	7.00e-97	347.00
IUUC-Ete-032281	Echinops telfairi	65.16	9.00e-85	306.00
IUUC-Eca-033228	Equus caballus	80.62	1.00e-136	478.00
IUUC-Fca-036045	Felis catus	61.54	9.00e-19	84.00
IUUC-Fal-037507	Ficedula albicollis	71.83	0.00e+00	690.00
IUUC-Gmo-038744	Gadus morhua	57.89	1.00e-87	316.00
IUUC-Gga-040353	Gallus gallus	71.37	0.00e+00	674.00
IUUC-Gac-042519	Gasterosteus aculeatus	50.11	2.00e-124	438.00
IUUC-Hsa-046016	Homo sapiens	83.80	0.00e+00	767.00
IUUC-Loc-052389	Lepisosteus oculatus	63.97	6.00e-162	563.00
IUUC-Laf-053412	Loxodonta africana	58.43	4.00e-24	102.00
IUUC-Mcc-054933	Macaca mulatta	84.02	0.00e+00	766.00
IUUC-Meu-055963	Macropus eugenii	59.71	2.00e-122	431.00
IUUC-Mga-059626	Meleagris gallopavo	74.60	3.00e-24	102.00
IUUC-Mmr-061566	Microcebus murinus	82.73	1.00e-88	318.00
IUUC-Mdo-061952	Monodelphis domestica	86.44	2.00e-29	119.00
IUUC-Mmu-063561	Mus musculus	83.12	0.00e+00	793.00
IUUC-Mpu-065799	Mustela putorius furo	79.33	2.00e-133	468.00
IUUC-Mlu-068134	Myotis lucifugus	77.16	5.00e-146	509.00
IUUC-Ncr-068949	Neurospora crassa	34.07	2.00e-11	60.80
IUUC-Nle-070078	Nomascus leucogenys	84.78	1.00e-140	492.00
IUUC-Opr-070541	Ochotona princeps	80.74	0.00e+00	710.00
IUUC-Ont-071743	Oreochromis niloticus	52.49	5.00e-124	437.00
IUUC-Oan-073700	Ornithorhynchus anatinus	87.04	2.00e-24	102.00
IUUC-Ola-086426	Oryzias latipes	56.79	7.00e-51	192.00
IUUC-Oga-088867	Otolemur garnettii	82.72	0.00e+00	749.00
IUUC-Oar-089365	Ovis aries	81.89	1.00e-167	582.00
IUUC-Ptr-091371	Pan troglodytes	83.59	0.00e+00	763.00
IUUC-Pan-092443	Papio anubis	84.38	1.00e-139	488.00
IUUC-Psi-093851	Pelodiscus sinensis	67.93	2.00e-93	335.00
IUUC-Pfo-097194	Poecilia formosa	50.65	6.00e-123	433.00
IUUC-Pab-097999	Pongo abelii	71.47	2.00e-133	468.00
IUUC-Pca-100410	Procavia capensis	72.94	9.00e-172	595.00
IUUC-Pva-102300	Pteropus vampyrus	71.58	7.00e-180	622.00
IUUC-Rno-105556	Rattus norvegicus	84.03	6.00e-141	493.00
IUUC-Sha-106992	Sarcophilus harrisii	92.59	9.00e-26	107.00
IUUC-Sar-113121	Sorex araneus	83.62	8.00e-52	197.00
IUUC-Ssc-116435	Sus scrofa	80.84	7.00e-131	459.00
IUUC-Tgu-117489	Taeniopygia guttata	71.55	0.00e+00	684.00
IUUC-Tru-117927	Takifugu rubripes	50.00	2.00e-133	469.00
IUUC-Tsy-119372	Tarsius syrichta	85.32	1.00e-161	562.00
IUUC-Tni-120043	Tetraodon nigroviridis	50.41	3.00e-122	431.00
IUUC-Tre-122176	Trichoderma reesei	43.08	2.00e-09	57.80
IUUC-Tvi-122588	Trichoderma virens	23.26	1.00e-11	64.70
IUUC-Tbe-127539	Tupaia belangeri	73.16	0.00e+00	644.00
IUUC-Ttr-129149	Tursiops truncatus	78.40	0.00e+00	737.00
IUUC-Vpa-130439	Vicugna pacos	58.84	4.00e-144	504.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence