iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021819

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02056864

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000010638.3	ENSCPOT00000010735.2	ENSCPOP00000009549.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.70e-83	278.4	4458	4789

Active Site

Position(s)	Description	Evidence
4758	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflG..rllgkalqdgr 86
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h  +F+flG  +llg+a+++g 
   Q: 4458 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLFNPaarapVHGGMFRFLGagVLLGIAIRTGS 4544
           4566*******************************************************9*9999*******85338********** PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeY 173
           +l l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++ +++t +N+ eY
   Q: 4545 PLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKYTHITLDNRAEY 4626
           *****************************************9999999999***99.....788999999***************** PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefssee 260
           v+l ++yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + +qwFwev+e+fs++e
   Q: 4627 VRLAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPSASLVQWFWEVMESFSNTE 4711
           ***********.**************************************************77.********************** PP
   S: 261  rkafLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           r+ fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4712 RSLFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4789
           ***************.8*************999988888***********************************99875 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MPSESFCLGA QARLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGS ELSQSGEFPP 60
RKDDGVDTQS GAKKEDLSDK EKKDDEEAPA PALRAKSILE SWVWGRQPDV KELKECLSVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCCTCTG AATCCTTCTG TTTGGGTGCC CAGGCGCGAC TTGACTCCAA ATGGCTGAAA 60
ACAGATATAC AGGTCGGGGT CTGTTACGCT TTTACCTTGT TGTGTAGCTG TCTGCACATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	93.62	0.00e+00	6907.00
IUUC-Apl-003983	Anas platyrhynchos	88.42	0.00e+00	8074.00
IUUC-Aca-004300	Anolis carolinensis	87.68	0.00e+00	7942.00
IUUC-Ath-007268	Arabidopsis thaliana	33.19	2.00e-28	121.00
IUUC-Ame-010621	Astyanax mexicanus	82.35	0.00e+00	6662.00
IUUC-Bta-013067	Bos taurus	92.56	0.00e+00	8314.00
IUUC-Cja-019687	Callithrix jacchus	92.06	0.00e+00	8185.00
IUUC-Cfa-020672	Canis familiaris	93.70	0.00e+00	8430.00
IUUC-Csa-023817	Chlorocebus sabaeus	93.83	0.00e+00	8416.00
IUUC-Cho-024387	Choloepus hoffmanni	94.93	0.00e+00	1818.00
IUUC-Cin-025709	Ciona intestinalis	58.91	0.00e+00	1436.00
IUUC-Csv-026336	Ciona savignyi	53.87	0.00e+00	1469.00
IUUC-Dre-027717	Danio rerio	79.64	0.00e+00	6987.00
IUUC-Dno-029296	Dasypus novemcinctus	92.83	0.00e+00	8329.00
IUUC-Dor-030979	Dipodomys ordii	86.11	0.00e+00	2676.00
IUUC-Dme-032171	Drosophila melanogaster	60.03	0.00e+00	1514.00
IUUC-Ete-032687	Echinops telfairi	84.41	0.00e+00	2847.00
IUUC-Eca-034046	Equus caballus	92.82	0.00e+00	8345.00
IUUC-Eeu-034859	Erinaceus europaeus	82.41	0.00e+00	1918.00
IUUC-Fca-036262	Felis catus	93.64	0.00e+00	8455.00
IUUC-Fal-037562	Ficedula albicollis	88.26	0.00e+00	8009.00
IUUC-Gmo-039054	Gadus morhua	86.48	0.00e+00	1094.00
IUUC-Gga-040359	Gallus gallus	88.37	0.00e+00	8039.00
IUUC-Gac-041879	Gasterosteus aculeatus	90.59	0.00e+00	1043.00
IUUC-Ggo-044692	Gorilla gorilla	92.86	0.00e+00	4066.00
IUUC-Hsa-045995	Homo sapiens	93.95	0.00e+00	8452.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	95.58	0.00e+00	2455.00
IUUC-Lch-049808	Latimeria chalumnae	84.47	0.00e+00	3216.00
IUUC-Loc-052685	Lepisosteus oculatus	82.15	0.00e+00	7298.00
IUUC-Laf-053372	Loxodonta africana	92.22	0.00e+00	8282.00
IUUC-Mcc-054693	Macaca mulatta	93.91	0.00e+00	8451.00
IUUC-Meu-056660	Macropus eugenii	95.92	0.00e+00	1925.00
IUUC-Mga-059371	Meleagris gallopavo	88.37	0.00e+00	6928.00
IUUC-Mmr-060787	Microcebus murinus	94.45	0.00e+00	8522.00
IUUC-Mdo-062518	Monodelphis domestica	86.88	0.00e+00	7747.00
IUUC-Mmu-063690	Mus musculus	93.14	0.00e+00	8379.00
IUUC-Mpu-066478	Mustela putorius furo	93.50	0.00e+00	8395.00
IUUC-Mlu-067596	Myotis lucifugus	85.93	0.00e+00	4086.00
IUUC-Nle-069445	Nomascus leucogenys	94.83	0.00e+00	2172.00
IUUC-Opr-070990	Ochotona princeps	87.90	0.00e+00	2582.00
IUUC-Ont-072285	Oreochromis niloticus	80.72	0.00e+00	7092.00
IUUC-Oan-072721	Ornithorhynchus anatinus	83.96	0.00e+00	3284.00
IUUC-Ocu-074273	Oryctolagus cuniculus	93.84	0.00e+00	8459.00
IUUC-Ola-087346	Oryzias latipes	92.42	0.00e+00	1195.00
IUUC-Oga-088742	Otolemur garnettii	93.28	0.00e+00	8336.00
IUUC-Oar-090093	Ovis aries	92.73	0.00e+00	8329.00
IUUC-Ptr-091034	Pan troglodytes	87.98	0.00e+00	5463.00
IUUC-Pan-092783	Papio anubis	91.66	0.00e+00	8221.00
IUUC-Psi-094027	Pelodiscus sinensis	88.59	0.00e+00	7710.00
IUUC-Pfo-096208	Poecilia formosa	78.03	0.00e+00	5741.00
IUUC-Pab-097681	Pongo abelii	93.05	0.00e+00	2589.00
IUUC-Pca-100705	Procavia capensis	95.82	0.00e+00	1176.00
IUUC-Pva-103147	Pteropus vampyrus	85.77	0.00e+00	2498.00
IUUC-Rno-105458	Rattus norvegicus	93.17	0.00e+00	8367.00
IUUC-Sha-106959	Sarcophilus harrisii	79.34	0.00e+00	6710.00
IUUC-Sar-113532	Sorex araneus	77.45	0.00e+00	1583.00
IUUC-Sbi-114352	Sorghum bicolor	31.50	3.00e-45	177.00
IUUC-Ssc-115337	Sus scrofa	91.54	0.00e+00	3007.00
IUUC-Tgu-116789	Taeniopygia guttata	88.31	0.00e+00	8031.00
IUUC-Tru-118129	Takifugu rubripes	80.22	0.00e+00	7128.00
IUUC-Tsy-119302	Tarsius syrichta	90.73	0.00e+00	994.00
IUUC-Tni-120374	Tetraodon nigroviridis	78.82	0.00e+00	6967.00
IUUC-Tbe-128137	Tupaia belangeri	86.89	0.00e+00	2303.00
IUUC-Ttr-128273	Tursiops truncatus	87.84	0.00e+00	6078.00
IUUC-Vpa-130471	Vicugna pacos	71.44	0.00e+00	1241.00
IUUC-Xtr-132185	Xenopus tropicalis	83.69	0.00e+00	7542.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence