iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036684

Ensembl Protein ID

ENSFALP00000001657.1

UniProt Accession

U3JFV3; U3JFV3_FICAL

Genbank Protein ID

ENSFALP00000001657

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01010823

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000001592.1	ENSFALT00000001666.1	ENSFALP00000001657.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.30e-18	64.2	837	888

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 837  ARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKG--ETNGRVGWFPSTYVEE 888
           67**********************************..9*************86 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MEEWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SDLFDPFDLF DVRDFGKVIS AVSRLSFHSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC 60
CCCCCCCCTT CCCTACACGA CGCTCTTCCG ATCTTCCTCC TCCTCCTCTT CCTCCTCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	87.97	0.00e+00	1430.00
IUUC-Apl-003262	Anas platyrhynchos	94.51	0.00e+00	1605.00
IUUC-Aca-004628	Anolis carolinensis	66.08	0.00e+00	928.00
IUUC-Ath-007352	Arabidopsis thaliana	36.21	5.00e-03	36.20
IUUC-Ame-011608	Astyanax mexicanus	79.80	0.00e+00	1451.00
IUUC-Bta-013147	Bos taurus	87.21	0.00e+00	1250.00
IUUC-Cja-018877	Callithrix jacchus	87.26	0.00e+00	1360.00
IUUC-Cfa-020315	Canis familiaris	84.64	0.00e+00	1182.00
IUUC-Cpo-021543	Cavia porcellus	86.35	0.00e+00	1262.00
IUUC-Cre-022802	Chlamydomonas reinhardtii	44.19	6.20e+00	27.70
IUUC-Csa-024204	Chlorocebus sabaeus	88.79	0.00e+00	1568.00
IUUC-Cin-025115	Ciona intestinalis	36.14	1.00e-145	510.00
IUUC-Csv-025995	Ciona savignyi	35.36	6.00e-146	511.00
IUUC-Dre-028308	Danio rerio	82.39	0.00e+00	1481.00
IUUC-Dno-029584	Dasypus novemcinctus	81.86	0.00e+00	1095.00
IUUC-Dor-031014	Dipodomys ordii	77.26	0.00e+00	1175.00
IUUC-Eca-033448	Equus caballus	87.89	0.00e+00	1541.00
IUUC-Eeu-035182	Erinaceus europaeus	78.80	0.00e+00	651.00
IUUC-Fca-035460	Felis catus	85.90	0.00e+00	1256.00
IUUC-Gmo-038816	Gadus morhua	73.71	0.00e+00	1095.00
IUUC-Gga-040999	Gallus gallus	92.04	0.00e+00	1589.00
IUUC-Gac-041353	Gasterosteus aculeatus	75.13	0.00e+00	1148.00
IUUC-Ggo-044558	Gorilla gorilla	90.81	0.00e+00	1585.00
IUUC-Hsa-046208	Homo sapiens	90.70	0.00e+00	1583.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	83.78	0.00e+00	1139.00
IUUC-Loc-052827	Lepisosteus oculatus	80.58	0.00e+00	1491.00
IUUC-Laf-054009	Loxodonta africana	84.88	0.00e+00	1476.00
IUUC-Mcc-055054	Macaca mulatta	90.58	0.00e+00	1580.00
IUUC-Mga-060106	Meleagris gallopavo	95.40	0.00e+00	1623.00
IUUC-Mmr-061118	Microcebus murinus	87.33	0.00e+00	1518.00
IUUC-Mdo-062380	Monodelphis domestica	86.26	0.00e+00	1283.00
IUUC-Mmu-063135	Mus musculus	89.80	0.00e+00	1572.00
IUUC-Mpu-066135	Mustela putorius furo	83.67	0.00e+00	1369.00
IUUC-Nle-069465	Nomascus leucogenys	82.50	0.00e+00	1407.00
IUUC-Ont-071945	Oreochromis niloticus	81.03	0.00e+00	1435.00
IUUC-Oan-073384	Ornithorhynchus anatinus	85.27	0.00e+00	1185.00
IUUC-Ola-087499	Oryzias latipes	74.29	0.00e+00	1069.00
IUUC-Oga-088444	Otolemur garnettii	84.46	0.00e+00	1234.00
IUUC-Oar-089576	Ovis aries	83.85	0.00e+00	1173.00
IUUC-Ptr-090507	Pan troglodytes	89.57	0.00e+00	1543.00
IUUC-Pan-092325	Papio anubis	87.00	0.00e+00	1504.00
IUUC-Psi-094021	Pelodiscus sinensis	89.79	0.00e+00	1541.00
IUUC-Pma-094372	Petromyzon marinus	53.07	0.00e+00	705.00
IUUC-Pfo-096732	Poecilia formosa	81.72	0.00e+00	1467.00
IUUC-Pab-098426	Pongo abelii	72.41	0.00e+00	1085.00
IUUC-Pca-100295	Procavia capensis	87.50	0.00e+00	1434.00
IUUC-Rno-105332	Rattus norvegicus	88.79	0.00e+00	1498.00
IUUC-Sha-106529	Sarcophilus harrisii	91.02	0.00e+00	1271.00
IUUC-Ssc-116176	Sus scrofa	87.00	0.00e+00	1375.00
IUUC-Tgu-116917	Taeniopygia guttata	95.27	0.00e+00	1480.00
IUUC-Tru-118398	Takifugu rubripes	79.91	0.00e+00	1014.00
IUUC-Tni-120819	Tetraodon nigroviridis	78.10	0.00e+00	1209.00
IUUC-Xtr-132747	Xenopus tropicalis	77.60	0.00e+00	1354.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence