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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064288
UUCD1 version UUC-MuM-00603
Ensembl Protein ID ENSMUSP00000042558.7
UniProt Accession Q8BFQ9; Q6ZPT4; KLH42_MOUSE
Genbank Protein ID BAC33488.1; BAC38745.1; BAC98145.1
Protein Name Kelch-like protein 42; Cullin-3-binding protein 9; Kelch domain-containing protein 5
Genbank Nucleotide ID AK048908; AK083047; AK129335
Gene Name Klhl42; Kiaa1340; Klhdc5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040102.10 ENSMUST00000036003.7 ENSMUSP00000042558.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/BCR/BTB_3-box 91.29 0.00e+00 890.00 IUUC-Hsa-046283
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis (By similarity).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis (By similarity).
Protein Sequence
(Fasta)
MSAEEMVQIR LEDRCYPVSK SKLIEQSDYF RALYRSGMRE AVRPEVGPEV QQLRGLSAPG 60
LRLVLDFINA GGAREGWGLS EDELAEASVL SEMVEAASFL QVTALLRLLL SHVRLGNCLE 120
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Protein Fasta Sequence


>IUUC-Mmu-064288|E3,BTB_3-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GAGGGCGTGT GACGCACCGG CGGGGCTGAG CCCGGGGCCC GCGGCCCGCG GCGGCGGAAG 60
GAAGGAAGCG AGAGCGCAGG CCGGGCTCGG CGGAGGCTGT GCGCCCGGGG GAGGAGCCTG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064288|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF01344--Kelch_1
SMART

SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005819--C:spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0032886--P:regulation of microtubule-based process
KEGG mmu:232539
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002285 Ailuropoda melanoleuca 92.32 0.00e+00 894.00
IUUC-Apl-004005 Anas platyrhynchos 72.18 0.00e+00 671.00
IUUC-Aca-004932 Anolis carolinensis 59.80 1.00e-143 503.00
IUUC-Ame-011389 Astyanax mexicanus 63.01 0.00e+00 634.00
IUUC-Bta-013120 Bos taurus 88.34 0.00e+00 860.00
IUUC-Cfa-020969 Canis familiaris 90.69 0.00e+00 882.00
IUUC-Cpo-022181 Cavia porcellus 85.31 0.00e+00 826.00
IUUC-Csa-023917 Chlorocebus sabaeus 90.69 0.00e+00 887.00
IUUC-Cho-024950 Choloepus hoffmanni 85.35 9.00e-165 572.00
IUUC-Dre-028648 Danio rerio 60.77 1.00e-178 619.00
IUUC-Dno-028937 Dasypus novemcinctus 76.42 0.00e+00 696.00
IUUC-Dor-031019 Dipodomys ordii 77.16 2.00e-116 412.00
IUUC-Ete-032490 Echinops telfairi 81.98 0.00e+00 782.00
IUUC-Eca-033326 Equus caballus 90.89 0.00e+00 890.00
IUUC-Eeu-034985 Erinaceus europaeus 90.34 9.00e-77 280.00
IUUC-Fca-035493 Felis catus 93.99 0.00e+00 757.00
IUUC-Fal-036818 Ficedula albicollis 68.72 8.00e-155 540.00
IUUC-Gmo-039278 Gadus morhua 48.96 3.00e-60 224.00
IUUC-Gga-040470 Gallus gallus 72.51 0.00e+00 644.00
IUUC-Gac-041998 Gasterosteus aculeatus 60.57 5.00e-176 610.00
IUUC-Ggo-045547 Gorilla gorilla 90.84 0.00e+00 882.00
IUUC-Hsa-046283 Homo sapiens 90.89 0.00e+00 888.00
IUUC-Itr-048418 Ictidomys tridecemlineatus 92.91 0.00e+00 927.00
IUUC-Lch-049748 Latimeria chalumnae 61.73 7.00e-180 623.00
IUUC-Loc-052270 Lepisosteus oculatus 61.76 0.00e+00 626.00
IUUC-Laf-054165 Loxodonta africana 88.86 0.00e+00 728.00
IUUC-Mcc-054993 Macaca mulatta 87.89 2.00e-165 575.00
IUUC-Meu-056500 Macropus eugenii 84.43 2.00e-176 611.00
IUUC-Mga-059376 Meleagris gallopavo 72.56 0.00e+00 662.00
IUUC-Mmr-060782 Microcebus murinus 88.71 0.00e+00 886.00
IUUC-Mdo-062068 Monodelphis domestica 80.85 0.00e+00 751.00
IUUC-Mpu-065815 Mustela putorius furo 90.30 0.00e+00 905.00
IUUC-Mlu-067560 Myotis lucifugus 90.58 0.00e+00 867.00
IUUC-Nle-069737 Nomascus leucogenys 90.89 0.00e+00 887.00
IUUC-Opr-070332 Ochotona princeps 85.06 0.00e+00 842.00
IUUC-Ont-072368 Oreochromis niloticus 61.38 1.00e-170 592.00
IUUC-Ocu-074509 Oryctolagus cuniculus 90.10 0.00e+00 877.00
IUUC-Ola-087330 Oryzias latipes 58.94 1.00e-170 593.00
IUUC-Oga-089095 Otolemur garnettii 91.09 0.00e+00 890.00
IUUC-Oar-090108 Ovis aries 96.20 0.00e+00 644.00
IUUC-Ptr-091031 Pan troglodytes 90.89 0.00e+00 888.00
IUUC-Pan-091834 Papio anubis 90.50 0.00e+00 879.00
IUUC-Psi-093483 Pelodiscus sinensis 69.98 1.00e-169 589.00
IUUC-Pfo-097126 Poecilia formosa 60.57 9.00e-176 609.00
IUUC-Pab-098446 Pongo abelii 90.89 0.00e+00 887.00
IUUC-Pca-100423 Procavia capensis 88.32 0.00e+00 874.00
IUUC-Pva-102436 Pteropus vampyrus 69.46 2.00e-158 551.00
IUUC-Rno-105244 Rattus norvegicus 99.19 0.00e+00 967.00
IUUC-Sha-107215 Sarcophilus harrisii 78.05 0.00e+00 765.00
IUUC-Ssc-115433 Sus scrofa 89.90 0.00e+00 878.00
IUUC-Tgu-116589 Taeniopygia guttata 68.14 6.00e-173 600.00
IUUC-Tru-118575 Takifugu rubripes 60.76 6.00e-177 613.00
IUUC-Tsy-118895 Tarsius syrichta 85.90 0.00e+00 667.00
IUUC-Tni-119944 Tetraodon nigroviridis 60.53 9.00e-176 609.00
IUUC-Ttr-128828 Tursiops truncatus 94.99 0.00e+00 677.00
IUUC-Vpa-130506 Vicugna pacos 89.49 0.00e+00 652.00
IUUC-Xtr-131850 Xenopus tropicalis 47.70 2.00e-108 385.00
Created Date 25-Jun-2017

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