iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012508

Ensembl Protein ID

ENSBTAP00000014162.2

UniProt Accession

Q5E9A1; Q3T0K5; NACA_BOVIN

Genbank Protein ID

AAX09036.1; AAI02358.1

Protein Name

Nascent polypeptide-associated complex subunit alpha; Alpha-NAC

Genbank Nucleotide ID

BT021019; BC102357

Gene Name

NACA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010701.4	ENSBTAT00000014162.2	ENSBTAP00000014162.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	38.51	4.00e-19	89.40	IUUC-Sce-106371
UBD/Alpha-Helix/UBA	47.65	2.00e-24	106.00	IUUC-Spo-108121

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.

Protein Sequence
(Fasta)

MPGEATDTVP ATEQELPQPQ AETGSGTESD SDESVPELEE QDSTQATTQQ AQLAAAAEID 60
EEPVSKAKQS RSEKKARKAM SKLGLRQVTG VTRVTIRKSK NILFVITKPD VYKSPASDTY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGCCATCT TGGTTCCGCG TTCCCCGCAC AGTAAGTGCT TGTCTTCGCC GCTACTTTTT 60
ATCCGTAGCC ATCCGCCTTT CTTGCGGCCT GAGGCGCCGC GCAGAGTAAG AGCTAAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0804--Transcription
KW-0813--Transport

Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom

PROSITE

PS51151--NAC_AB

Pfam

PF01849--NAC

SMART

SM01407--NAC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0017025--F:TBP-class protein binding
GO:0003713--F:transcription coactivator activity
GO:0015031--P:protein transport
GO:0006351--P:transcription, DNA-templated

KEGG

bta:513312

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001167	Aegilops tauschii	62.50	1.00e-35	142.00
IUUC-Aml-001719	Ailuropoda melanoleuca	100.00	8.00e-86	313.00
IUUC-Atr-002586	Amborella trichopoda	50.00	7.00e-28	117.00
IUUC-Apl-003190	Anas platyrhynchos	72.61	5.00e-53	199.00
IUUC-Aca-005265	Anolis carolinensis	97.40	3.00e-84	303.00
IUUC-Aly-006397	Arabidopsis lyrata	62.50	1.00e-37	149.00
IUUC-Ath-007378	Arabidopsis thaliana	59.42	2.00e-30	125.00
IUUC-Ago-007936	Ashbya gossypii	39.63	2.00e-22	97.80
IUUC-Acl-008036	Aspergillus clavatus	70.49	3.00e-23	101.00
IUUC-Afl-008462	Aspergillus flavus	51.57	2.00e-35	141.00
IUUC-Afu-008832	Aspergillus fumigatus	70.49	2.00e-23	101.00
IUUC-Ani-009246	Aspergillus nidulans	70.31	9.00e-25	106.00
IUUC-Ang-009808	Aspergillus niger	50.63	2.00e-33	135.00
IUUC-Aor-009972	Aspergillus oryzae	51.57	2.00e-35	141.00
IUUC-Ame-011674	Astyanax mexicanus	95.35	9.00e-86	309.00
IUUC-Bgr-012162	Blumeria graminis	51.52	2.00e-36	145.00
IUUC-Bci-013643	Botrytis cinerea	50.90	1.00e-33	135.00
IUUC-Bdi-014874	Brachypodium distachyon	59.56	9.00e-34	136.00
IUUC-Bol-015681	Brassica oleracea	58.82	3.00e-36	144.00
IUUC-Bra-017540	Brassica rapa	59.42	4.00e-35	140.00
IUUC-Cel-018111	Caenorhabditis elegans	66.01	1.00e-47	182.00
IUUC-Cja-019846	Callithrix jacchus	62.25	4.00e-59	224.00
IUUC-Cfa-020429	Canis familiaris	95.17	7.00e-84	302.00
IUUC-Cpo-022542	Cavia porcellus	99.05	9.00e-87	312.00
IUUC-Cre-022679	Chlamydomonas reinhardtii	66.00	3.00e-48	183.00
IUUC-Csa-023260	Chlorocebus sabaeus	65.33	2.00e-59	225.00
IUUC-Cho-024869	Choloepus hoffmanni	75.25	4.00e-51	194.00
IUUC-Cin-025166	Ciona intestinalis	72.00	5.00e-51	193.00
IUUC-Csv-026284	Ciona savignyi	70.59	2.00e-43	167.00
IUUC-Cgl-026520	Colletotrichum gloeosporioides	56.05	7.00e-33	133.00
IUUC-Cne-026920	Cryptococcus neoformans	61.29	4.00e-21	94.40
IUUC-Cme-027301	Cyanidioschyzon merolae	50.00	5.00e-29	120.00
IUUC-Dre-028709	Danio rerio	95.88	6.00e-82	299.00
IUUC-Dno-029786	Dasypus novemcinctus	100.00	9.00e-85	309.00
IUUC-Dor-030962	Dipodomys ordii	93.95	1.00e-91	328.00
IUUC-Dme-032061	Drosophila melanogaster	70.78	4.00e-37	147.00
IUUC-Ete-032965	Echinops telfairi	93.20	2.00e-87	314.00
IUUC-Eca-034049	Equus caballus	99.07	2.00e-95	340.00
IUUC-Eeu-034673	Erinaceus europaeus	99.53	4.00e-96	343.00
IUUC-Fca-036369	Felis catus	100.00	2.00e-85	311.00
IUUC-Fal-037006	Ficedula albicollis	99.48	2.00e-81	295.00
IUUC-Fox-037704	Fusarium oxysporum	53.09	4.00e-33	134.00
IUUC-Fso-038247	Fusarium solani	51.22	9.00e-33	133.00
IUUC-Gmo-039002	Gadus morhua	69.23	2.00e-50	192.00
IUUC-Ggr-039888	Gaeumannomyces graminis	51.88	2.00e-33	135.00
IUUC-Gga-040237	Gallus gallus	99.07	1.00e-95	342.00
IUUC-Gac-041800	Gasterosteus aculeatus	96.37	1.00e-70	260.00
IUUC-Gma-043275	Glycine max	63.76	1.00e-43	169.00
IUUC-Ggo-045163	Gorilla gorilla	62.67	6.00e-63	233.00
IUUC-Hsa-045795	Homo sapiens	100.00	6.00e-85	310.00
IUUC-Hvu-047376	Hordeum vulgare	62.50	6.00e-36	143.00
IUUC-Itr-048152	Ictidomys tridecemlineatus	99.53	4.00e-96	343.00
IUUC-Kpa-049166	Komagataella pastoris	38.79	1.00e-23	102.00
IUUC-Lch-050076	Latimeria chalumnae	97.67	3.00e-94	337.00
IUUC-Lpe-051258	Leersia perrieri	62.50	2.00e-37	148.00
IUUC-Loc-052292	Lepisosteus oculatus	96.21	1.00e-75	275.00
IUUC-Lma-053293	Leptosphaeria maculans	69.12	2.00e-25	108.00
IUUC-Laf-054393	Loxodonta africana	59.91	1.00e-60	225.00
IUUC-Mcc-054632	Macaca mulatta	100.00	2.00e-84	308.00
IUUC-Meu-056242	Macropus eugenii	91.16	7.00e-83	299.00
IUUC-Mor-057099	Magnaporthe oryzae	54.19	2.00e-30	125.00
IUUC-Mpo-057543	Magnaporthe poae	44.22	1.00e-24	105.00
IUUC-Mtr-058769	Medicago truncatula	57.97	9.00e-29	119.00
IUUC-Mla-059166	Melampsora laricipopulina	41.67	4.00e-24	104.00
IUUC-Mga-059406	Meleagris gallopavo	92.06	2.00e-83	301.00
IUUC-Mvi-060390	Microbotryum violaceum	39.38	2.00e-23	101.00
IUUC-Mmr-061569	Microcebus murinus	97.46	1.00e-81	295.00
IUUC-Mdo-062077	Monodelphis domestica	100.00	3.00e-77	283.00
IUUC-Mmu-063984	Mus musculus	98.96	3.00e-85	311.00
IUUC-Mac-065175	Musa acuminata	62.50	4.00e-38	150.00
IUUC-Mpu-065793	Mustela putorius furo	95.31	1.00e-77	286.00
IUUC-Mlu-068234	Myotis lucifugus	99.53	4.00e-96	343.00
IUUC-Nfi-068541	Neosartorya fischeri	70.49	2.00e-23	101.00
IUUC-Ncr-068830	Neurospora crassa	56.21	3.00e-32	131.00
IUUC-Nle-069126	Nomascus leucogenys	99.07	2.00e-94	338.00
IUUC-Opr-070742	Ochotona princeps	86.05	6.00e-82	296.00
IUUC-Ont-071828	Oreochromis niloticus	94.85	8.00e-73	266.00
IUUC-Oan-073462	Ornithorhynchus anatinus	99.47	2.00e-81	297.00
IUUC-Ocu-074890	Oryctolagus cuniculus	63.32	1.00e-59	225.00
IUUC-Oba-075995	Oryza barthii	59.72	2.00e-39	155.00
IUUC-Obr-076073	Oryza brachyantha	58.33	2.00e-39	155.00
IUUC-Ogl-077445	Oryza glaberrima	59.72	2.00e-39	155.00
IUUC-Ogu-078606	Oryza glumaepatula	59.72	2.00e-39	155.00
IUUC-Oin-079287	Oryza indica	59.72	2.00e-39	155.00
IUUC-Olo-080686	Oryza longistaminata	55.48	2.00e-34	139.00
IUUC-Ome-081567	Oryza meridionalis	63.24	1.00e-38	151.00
IUUC-Oni-082873	Oryza nivara	59.72	2.00e-39	155.00
IUUC-Opu-083488	Oryza punctata	58.70	1.00e-36	145.00
IUUC-Oru-084592	Oryza rufipogon	59.72	2.00e-39	155.00
IUUC-Osa-086102	Oryza sativa	59.72	2.00e-39	155.00
IUUC-Ola-087531	Oryzias latipes	94.88	8.00e-81	292.00
IUUC-Olu-087895	Ostreococcus lucimarinus	53.28	3.00e-31	126.00
IUUC-Oga-088239	Otolemur garnettii	99.53	4.00e-96	343.00
IUUC-Oar-089723	Ovis aries	100.00	4.00e-86	313.00
IUUC-Ptr-090481	Pan troglodytes	67.68	4.00e-58	220.00
IUUC-Pan-092223	Papio anubis	100.00	3.00e-83	303.00
IUUC-Psi-093588	Pelodiscus sinensis	98.60	4.00e-96	343.00
IUUC-Pma-094702	Petromyzon marinus	78.44	5.00e-63	233.00
IUUC-Pno-094927	Phaeosphaeria nodorum	69.12	2.00e-25	108.00
IUUC-Ppa-095389	Physcomitrella patens	66.67	5.00e-40	157.00
IUUC-Pfo-096744	Poecilia formosa	93.95	9.00e-76	276.00
IUUC-Pab-098044	Pongo abelii	99.53	4.00e-96	343.00
IUUC-Pop-099384	Populus trichocarpa	65.10	3.00e-44	171.00
IUUC-Pca-100355	Procavia capensis	67.84	1.00e-58	222.00
IUUC-Ppe-101786	Prunus persica	62.50	3.00e-39	154.00
IUUC-Pva-102494	Pteropus vampyrus	97.67	3.00e-94	337.00
IUUC-Pgr-103303	Puccinia graminis	40.88	1.00e-25	109.00
IUUC-Ptt-103748	Puccinia triticina	33.58	6.00e-12	63.90
IUUC-Pte-104368	Pyrenophora teres	49.70	7.00e-35	140.00
IUUC-Pyt-104542	Pyrenophora triticirepentis	69.12	2.00e-25	108.00
IUUC-Rno-105387	Rattus norvegicus	98.96	4.00e-85	310.00
IUUC-Sce-106371	Saccharomyces cerevisiae	38.89	3.00e-20	90.90
IUUC-Sha-107189	Sarcophilus harrisii	99.53	4.00e-96	343.00
IUUC-Sja-107942	Schizosaccharomyces japonicus	45.40	2.00e-24	104.00
IUUC-Spo-108121	Schizosaccharomyces pombe	47.65	3.00e-27	114.00
IUUC-Ssl-108595	Sclerotinia sclerotiorum	71.88	5.00e-24	103.00
IUUC-Smo-108783	Selaginella moellendorffii	66.18	1.00e-39	155.00
IUUC-Sit-110180	Setaria italica	63.97	3.00e-39	154.00
IUUC-Sly-110957	Solanum lycopersicum	63.24	3.00e-35	140.00
IUUC-Stu-112873	Solanum tuberosum	63.24	3.00e-35	141.00
IUUC-Sar-113668	Sorex araneus	100.00	2.00e-29	122.00
IUUC-Sbi-114223	Sorghum bicolor	63.97	8.00e-36	143.00
IUUC-Sre-115220	Sporisorium reilianum	44.00	1.00e-23	102.00
IUUC-Ssc-116119	Sus scrofa	99.53	4.00e-96	343.00
IUUC-Tgu-116528	Taeniopygia guttata	99.47	3.00e-79	286.00
IUUC-Tru-117538	Takifugu rubripes	89.62	2.00e-75	274.00
IUUC-Tsy-118855	Tarsius syrichta	100.00	7.00e-17	80.10
IUUC-Tni-120134	Tetraodon nigroviridis	94.88	6.00e-79	286.00
IUUC-Tca-121524	Theobroma cacao	62.50	2.00e-38	151.00
IUUC-Tre-121915	Trichoderma reesei	67.69	2.00e-20	92.40
IUUC-Tvi-122411	Trichoderma virens	68.85	1.00e-18	86.70
IUUC-Tae-124851	Triticum aestivum	59.72	5.00e-36	143.00
IUUC-Tur-126821	Triticum urartu	62.50	6.00e-36	143.00
IUUC-Tme-126875	Tuber melanosporum	69.70	8.00e-25	106.00
IUUC-Tbe-127759	Tupaia belangeri	89.30	2.00e-73	268.00
IUUC-Ttr-129124	Tursiops truncatus	67.32	5.00e-60	226.00
IUUC-Uma-129551	Ustilago maydis	45.03	3.00e-26	110.00
IUUC-Vda-129992	Verticillium dahliae	52.20	4.00e-33	134.00
IUUC-Vpa-130096	Vicugna pacos	97.21	9.00e-84	302.00
IUUC-Vvi-130940	Vitis vinifera	57.97	9.00e-31	126.00
IUUC-Xtr-132454	Xenopus tropicalis	96.91	7.00e-79	286.00
IUUC-Xma-133842	Xiphophorus maculatus	94.33	1.00e-72	265.00
IUUC-Yli-134485	Yarrowia lipolytica	47.54	1.00e-14	72.80
IUUC-Zma-135748	Zea mays	63.97	2.00e-39	154.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence