iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032586.9	ENSMUST00000049348.8	ENSMUSP00000040001.3
ENSMUSG00000032586.9	ENSMUST00000194271.1	ENSMUSP00000141689.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.10e-06	29.2	7	50

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC + f   +d +    CgH+fh++Cl +w     ++ ++ +CP Cr
   Q: 7    CTICSDFFdhsRD-VAAIHCGHTFHLQCLIQW----FETAPSRTCPQCR 50
           9***776655344.88999*************....9***********8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity) (PubMed:17544371, PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase. Might also play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity. The function in translesion synthesis is controversial (By similarity).

Protein Sequence
(Fasta)

MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKKTIIN 60
KLFFDLAQEE ENVLDAEFLK NELDSVKAQL SQKDREKRDS QAIIDTLRDT LEERNATVES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAGATTTC ATTCTGTCTT CCCCGGCTGG AGCAGACCTA CTTTATAAAG TTATGTATGC 60
TTCTTCTGAG GGAGTAATAC TGCTAACGAT ACCGTAAAAA TCGCTAAGGA GCCTCGCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005057--F:signal transducer activity, downstream of receptor
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032688--P:negative regulation of interferon-beta production
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0016567--P:protein ubiquitination
GO:0007165--P:signal transduction

KEGG

mmu:22036

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001411	Ailuropoda melanoleuca	74.68	0.00e+00	669.00
IUUC-Atr-002646	Amborella trichopoda	30.58	9.00e-08	52.00
IUUC-Apl-003777	Anas platyrhynchos	56.22	3.00e-109	388.00
IUUC-Aca-004476	Anolis carolinensis	55.20	1.00e-141	496.00
IUUC-Ame-011706	Astyanax mexicanus	42.00	1.00e-07	47.80
IUUC-Bta-013084	Bos taurus	75.64	0.00e+00	696.00
IUUC-Cel-018227	Caenorhabditis elegans	39.06	3.00e-11	63.20
IUUC-Cja-019856	Callithrix jacchus	79.49	0.00e+00	733.00
IUUC-Cfa-020075	Canis familiaris	77.56	0.00e+00	737.00
IUUC-Cpo-022481	Cavia porcellus	76.33	0.00e+00	719.00
IUUC-Csa-023793	Chlorocebus sabaeus	79.27	0.00e+00	757.00
IUUC-Csv-026190	Ciona savignyi	33.87	6.00e-41	160.00
IUUC-Dre-027984	Danio rerio	48.84	4.00e-124	437.00
IUUC-Dno-029478	Dasypus novemcinctus	75.64	0.00e+00	714.00
IUUC-Dor-030526	Dipodomys ordii	58.17	2.00e-149	522.00
IUUC-Dme-032130	Drosophila melanogaster	26.87	7.00e-20	91.70
IUUC-Ete-033012	Echinops telfairi	85.37	2.00e-142	499.00
IUUC-Eca-034084	Equus caballus	78.94	0.00e+00	751.00
IUUC-Eeu-034579	Erinaceus europaeus	71.63	2.00e-167	582.00
IUUC-Fca-035772	Felis catus	79.49	0.00e+00	734.00
IUUC-Fal-037098	Ficedula albicollis	58.30	2.00e-138	485.00
IUUC-Gmo-038704	Gadus morhua	46.78	1.00e-111	396.00
IUUC-Gga-041109	Gallus gallus	53.43	2.00e-137	482.00
IUUC-Gac-042636	Gasterosteus aculeatus	46.32	6.00e-120	424.00
IUUC-Ggo-045184	Gorilla gorilla	79.70	0.00e+00	762.00
IUUC-Hsa-046651	Homo sapiens	79.70	0.00e+00	731.00
IUUC-Itr-048550	Ictidomys tridecemlineatus	79.15	0.00e+00	768.00
IUUC-Lch-049575	Latimeria chalumnae	55.44	5.00e-133	467.00
IUUC-Lpe-051238	Leersia perrieri	34.78	8.00e-06	45.40
IUUC-Loc-051999	Lepisosteus oculatus	50.91	3.00e-124	438.00
IUUC-Lma-053133	Leptosphaeria maculans	42.11	1.00e-07	50.40
IUUC-Laf-053347	Loxodonta africana	77.66	0.00e+00	748.00
IUUC-Mcc-054668	Macaca mulatta	68.88	7.00e-73	266.00
IUUC-Meu-056862	Macropus eugenii	58.76	2.00e-155	541.00
IUUC-Mga-059443	Meleagris gallopavo	54.85	2.00e-114	405.00
IUUC-Mmr-061219	Microcebus murinus	77.61	0.00e+00	725.00
IUUC-Mdo-062103	Monodelphis domestica	66.88	0.00e+00	629.00
IUUC-Mpu-066570	Mustela putorius furo	77.78	0.00e+00	718.00
IUUC-Mlu-067806	Myotis lucifugus	78.30	0.00e+00	727.00
IUUC-Nle-069123	Nomascus leucogenys	80.13	0.00e+00	758.00
IUUC-Opr-071063	Ochotona princeps	77.45	0.00e+00	744.00
IUUC-Ont-071973	Oreochromis niloticus	48.09	9.00e-124	436.00
IUUC-Oan-073278	Ornithorhynchus anatinus	63.54	3.00e-93	334.00
IUUC-Ocu-074582	Oryctolagus cuniculus	72.54	0.00e+00	674.00
IUUC-Ogl-077006	Oryza glaberrima	36.23	3.00e-06	47.00
IUUC-Oin-079866	Oryza indica	25.00	2.00e-07	50.80
IUUC-Olo-081029	Oryza longistaminata	36.23	3.00e-06	47.00
IUUC-Osa-085981	Oryza sativa	25.00	2.00e-07	50.80
IUUC-Ola-086959	Oryzias latipes	47.59	4.00e-114	404.00
IUUC-Oga-088807	Otolemur garnettii	78.09	0.00e+00	706.00
IUUC-Oar-089273	Ovis aries	73.25	0.00e+00	678.00
IUUC-Ptr-090768	Pan troglodytes	79.70	0.00e+00	764.00
IUUC-Pan-091880	Papio anubis	79.27	0.00e+00	754.00
IUUC-Psi-093782	Pelodiscus sinensis	59.11	7.00e-134	470.00
IUUC-Pma-094365	Petromyzon marinus	36.55	4.00e-64	238.00
IUUC-Pfo-096068	Poecilia formosa	49.23	1.00e-115	410.00
IUUC-Pab-098063	Pongo abelii	77.40	0.00e+00	729.00
IUUC-Pca-100327	Procavia capensis	80.69	4.00e-164	570.00
IUUC-Pva-102924	Pteropus vampyrus	77.78	0.00e+00	719.00
IUUC-Pgr-103323	Puccinia graminis	25.10	5.00e-06	45.80
IUUC-Ptt-103972	Puccinia triticina	32.00	6.00e-07	48.90
IUUC-Pte-104366	Pyrenophora teres	30.77	3.00e-08	52.40
IUUC-Rno-105799	Rattus norvegicus	91.49	0.00e+00	878.00
IUUC-Sha-107643	Sarcophilus harrisii	61.84	4.00e-150	524.00
IUUC-Sit-109687	Setaria italica	36.23	8.00e-07	48.90
IUUC-Sar-113187	Sorex araneus	73.13	0.00e+00	633.00
IUUC-Sbi-114760	Sorghum bicolor	36.23	7.00e-07	48.90
IUUC-Ssc-115838	Sus scrofa	89.02	7.00e-138	483.00
IUUC-Tgu-116674	Taeniopygia guttata	56.31	2.00e-126	445.00
IUUC-Tru-117753	Takifugu rubripes	45.01	5.00e-114	404.00
IUUC-Tsy-119416	Tarsius syrichta	62.64	5.00e-55	208.00
IUUC-Tni-120767	Tetraodon nigroviridis	47.57	1.00e-111	397.00
IUUC-Tur-126115	Triticum urartu	23.31	2.00e-06	48.90
IUUC-Tbe-128001	Tupaia belangeri	46.22	1.00e-73	270.00
IUUC-Ttr-128687	Tursiops truncatus	79.15	0.00e+00	745.00
IUUC-Xtr-131905	Xenopus tropicalis	52.35	1.00e-138	486.00
IUUC-Xma-133304	Xiphophorus maculatus	49.47	1.00e-116	413.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence