iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040444

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Genbank Nucleotide ID

AADN04000198

Gene Name

RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000006392.3	ENSGALT00000010322.3	ENSGALP00000010308.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.70e-06	26.9	16	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C iC+e f + p++lpC+H+++ +C+         +++ +  CP Cr
   Q: 16   CQICMEVFVE-PVTLPCNHTICNSCFqLT------VENASLCCPFCR 55
           9*********.9**************444......5**********8 PP

Organism

Gallus gallus

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MSKKSEAPLS LDDCLCQICM EVFVEPVTLP CNHTICNSCF QLTVENASLC CPFCRRRVSS 60
WARYNARRNT LINWELWEKI QKKYPKECER RINGQDLEEE IFVPHPQHQL SKPGELRQEY 120

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Nucleotide Sequence
(Fasta)

AGTAGAAAGC AGGCTGCAAG CCTTGGAGAC GCGGTTCCAA GACCTGGACT CAAGCCTGCA 60
GAAGCTGGAG CAGAAGTTTG AGGTGCAGGC CGAGCTCCTG GAGAAGGAGA GGAGCCAGGA 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0031491--F:nucleosome binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0035518--P:histone H2A monoubiquitination
GO:0036351--P:histone H2A-K13 ubiquitination
GO:0036352--P:histone H2A-K15 ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

gga:770166

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	34.21	2.00e-09	57.00
IUUC-Aml-001573	Ailuropoda melanoleuca	40.29	6.00e-80	291.00
IUUC-Atr-002992	Amborella trichopoda	35.29	2.00e-09	56.20
IUUC-Apl-003963	Anas platyrhynchos	74.60	0.00e+00	661.00
IUUC-Aca-004420	Anolis carolinensis	76.03	3.00e-56	212.00
IUUC-Ath-007019	Arabidopsis thaliana	35.90	2.00e-08	54.70
IUUC-Ame-011521	Astyanax mexicanus	55.25	3.00e-44	172.00
IUUC-Bta-013002	Bos taurus	38.60	1.00e-74	273.00
IUUC-Cja-019945	Callithrix jacchus	39.61	2.00e-75	276.00
IUUC-Cfa-020533	Canis familiaris	38.41	2.00e-76	279.00
IUUC-Cpo-021643	Cavia porcellus	36.16	1.00e-53	204.00
IUUC-Csa-023638	Chlorocebus sabaeus	55.27	2.00e-53	203.00
IUUC-Cho-024319	Choloepus hoffmanni	38.85	3.00e-69	255.00
IUUC-Cin-025679	Ciona intestinalis	32.80	2.00e-23	102.00
IUUC-Csv-026052	Ciona savignyi	34.72	5.00e-24	104.00
IUUC-Dre-028519	Danio rerio	52.78	8.00e-40	157.00
IUUC-Dno-029294	Dasypus novemcinctus	39.24	3.00e-77	282.00
IUUC-Ete-032714	Echinops telfairi	61.54	4.00e-40	159.00
IUUC-Eca-033343	Equus caballus	42.76	1.00e-79	290.00
IUUC-Fca-036251	Felis catus	40.45	2.00e-79	290.00
IUUC-Fal-037048	Ficedula albicollis	64.75	0.00e+00	641.00
IUUC-Gmo-039400	Gadus morhua	49.58	1.00e-35	140.00
IUUC-Gac-041735	Gasterosteus aculeatus	49.47	1.00e-41	162.00
IUUC-Gma-044332	Glycine max	35.00	3.00e-11	62.80
IUUC-Ggo-044940	Gorilla gorilla	32.66	7.00e-28	118.00
IUUC-Hsa-046424	Homo sapiens	40.16	9.00e-75	274.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	41.27	2.00e-65	243.00
IUUC-Lch-050649	Latimeria chalumnae	66.84	8.00e-52	197.00
IUUC-Loc-051847	Lepisosteus oculatus	44.80	1.00e-46	180.00
IUUC-Laf-053938	Loxodonta africana	38.87	4.00e-77	281.00
IUUC-Mcc-055360	Macaca mulatta	39.33	3.00e-70	259.00
IUUC-Meu-056684	Macropus eugenii	40.07	1.00e-70	260.00
IUUC-Mtr-058007	Medicago truncatula	35.53	1.00e-10	60.80
IUUC-Mga-059699	Meleagris gallopavo	88.02	0.00e+00	961.00
IUUC-Mmr-060779	Microcebus murinus	40.10	3.00e-81	295.00
IUUC-Mdo-062225	Monodelphis domestica	42.36	1.00e-79	290.00
IUUC-Mmu-064239	Mus musculus	37.34	2.00e-60	226.00
IUUC-Mpu-066141	Mustela putorius furo	41.19	3.00e-86	312.00
IUUC-Mlu-067945	Myotis lucifugus	41.65	1.00e-73	270.00
IUUC-Nle-069769	Nomascus leucogenys	39.70	1.00e-72	267.00
IUUC-Opr-070905	Ochotona princeps	36.75	2.00e-65	243.00
IUUC-Ont-071477	Oreochromis niloticus	52.05	4.00e-39	155.00
IUUC-Oan-073587	Ornithorhynchus anatinus	68.50	3.00e-51	192.00
IUUC-Ocu-073832	Oryctolagus cuniculus	53.28	8.00e-50	191.00
IUUC-Ogl-077658	Oryza glaberrima	35.53	2.00e-09	56.20
IUUC-Oin-079383	Oryza indica	35.53	2.00e-09	56.60
IUUC-Ome-081482	Oryza meridionalis	35.53	2.00e-09	56.60
IUUC-Oni-083025	Oryza nivara	35.53	2.00e-09	56.60
IUUC-Opu-083547	Oryza punctata	34.72	8.00e-09	54.70
IUUC-Osa-085978	Oryza sativa	35.53	2.00e-09	56.60
IUUC-Ola-086478	Oryzias latipes	52.80	5.00e-38	149.00
IUUC-Oga-088318	Otolemur garnettii	39.44	1.00e-72	267.00
IUUC-Oar-089647	Ovis aries	38.62	1.00e-75	276.00
IUUC-Ptr-090516	Pan troglodytes	40.00	6.00e-76	278.00
IUUC-Pan-092302	Papio anubis	39.34	1.00e-68	253.00
IUUC-Psi-093604	Pelodiscus sinensis	52.98	7.00e-138	483.00
IUUC-Pfo-096441	Poecilia formosa	55.71	3.00e-46	178.00
IUUC-Pab-097729	Pongo abelii	50.88	2.00e-52	200.00
IUUC-Pca-100552	Procavia capensis	67.68	1.00e-39	157.00
IUUC-Ppe-102024	Prunus persica	35.00	2.00e-09	58.20
IUUC-Pva-102780	Pteropus vampyrus	38.45	2.00e-70	259.00
IUUC-Rno-105461	Rattus norvegicus	37.44	4.00e-70	258.00
IUUC-Sha-106809	Sarcophilus harrisii	42.90	5.00e-79	288.00
IUUC-Sly-111317	Solanum lycopersicum	34.00	1.00e-12	67.40
IUUC-Stu-112446	Solanum tuberosum	36.59	4.00e-12	65.50
IUUC-Sar-113579	Sorex araneus	62.84	6.00e-45	174.00
IUUC-Sbi-113834	Sorghum bicolor	36.84	3.00e-10	59.30
IUUC-Tgu-117187	Taeniopygia guttata	83.33	1.00e-86	311.00
IUUC-Tru-118182	Takifugu rubripes	52.45	1.00e-36	147.00
IUUC-Tni-120205	Tetraodon nigroviridis	55.80	1.00e-46	179.00
IUUC-Tca-121416	Theobroma cacao	35.00	7.00e-11	61.20
IUUC-Tvi-122557	Trichoderma virens	30.85	2.00e-05	43.90
IUUC-Tae-123092	Triticum aestivum	34.21	2.00e-09	57.00
IUUC-Tur-126688	Triticum urartu	35.53	7.00e-10	57.80
IUUC-Tbe-127622	Tupaia belangeri	40.36	5.00e-84	305.00
IUUC-Ttr-128988	Tursiops truncatus	39.35	5.00e-74	271.00
IUUC-Vpa-130302	Vicugna pacos	63.49	2.00e-45	177.00
IUUC-Xtr-132196	Xenopus tropicalis	54.24	2.00e-51	196.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence