iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000166359.10	ENST00000592765.5	ENSP00000467383.1
ENSG00000166359.10	ENST00000361680.6	ENSP00000355148.2
ENSG00000166359.10	ENST00000355868.3	ENSP00000348129.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-39	133.6	100	137
UBD/Beta-Prp	1.50e-55	190.1	224	393

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gH+  v+ ++f  +dt l+sGs+D+t+k+WD+ +g ++
   Q: 100  GHEHAVSTCHFcvDDTKLLSGSYDCTVKLWDPVDGSVV 137
           8***********777****************9999876 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl.sgheaevtavkfspdgkilvtgseDrtikvwdls......tgkcvh 88
           ++k+hh+  it+ +f pd++ +a+ s d++ik+wdvt++ +l ++ + h+++++ ++f  +g +l t+s D+++k+w++        g cv 
   Q: 224  VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTItKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHtgefrnCGACVT 315
           799**************************************99999*******************************999777777788*** PP
   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlk 167
            ++ghe sv s++f +++++l+sG+ drt+ +wd+ +g+     l+gh+++v+ v+++ +++ + s+s+Drt+rlW+++
   Q: 316  LMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKL-SLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
           ******************************************.**********************************94 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MASPPRCSPT AHDRECKLPP PSAPASEYCP GKLSWGTMAR ALGRFKLSIP HTHLLATLDP 60
LALDREPPPH LLPEKHQVPE KLIWGDQDPL SKIPFKILSG HEHAVSTCHF CVDDTKLLSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCGGGCGC GGGCGCGGGC GCGCGGCGCC ACCGTTCCCA TCCAGGCTTG TCGGCGGCCA 60
CCGGCGGACC GGGCTTCGAG ATGGCCTCCC CGCCGCGGTG CTCCCCGACA GCCCATGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR018391--PQQ_beta_propeller_repeat
IPR002372--PQQ_repeat
IPR011047--Quinoprotein_ADH-like_supfam
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF01011--PQQ
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00564--PQQ
SM00320--WD40

KEGG

hsa:126248

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001328	Ailuropoda melanoleuca	80.06	1.00e-155	542.00
IUUC-Apl-003571	Anas platyrhynchos	56.23	7.00e-122	430.00
IUUC-Aca-005232	Anolis carolinensis	49.41	9.00e-78	283.00
IUUC-Ame-011833	Astyanax mexicanus	49.48	4.00e-53	200.00
IUUC-Bta-013562	Bos taurus	75.00	9.00e-179	619.00
IUUC-Cja-019202	Callithrix jacchus	89.33	0.00e+00	846.00
IUUC-Cfa-021095	Canis familiaris	69.69	0.00e+00	636.00
IUUC-Cpo-022170	Cavia porcellus	72.75	0.00e+00	655.00
IUUC-Csa-024218	Chlorocebus sabaeus	94.28	0.00e+00	871.00
IUUC-Cho-024561	Choloepus hoffmanni	79.26	2.00e-129	455.00
IUUC-Dno-029722	Dasypus novemcinctus	76.32	2.00e-161	561.00
IUUC-Dor-030464	Dipodomys ordii	71.74	1.00e-139	488.00
IUUC-Ete-032931	Echinops telfairi	65.38	7.00e-118	417.00
IUUC-Eca-034428	Equus caballus	80.62	7.00e-176	609.00
IUUC-Eeu-034568	Erinaceus europaeus	61.13	1.00e-114	406.00
IUUC-Fca-035707	Felis catus	68.40	0.00e+00	635.00
IUUC-Gmo-039646	Gadus morhua	45.34	2.00e-74	272.00
IUUC-Gga-040710	Gallus gallus	55.71	9.00e-114	403.00
IUUC-Ggo-044611	Gorilla gorilla	65.63	2.00e-157	548.00
IUUC-Itr-048283	Ictidomys tridecemlineatus	67.34	6.00e-171	593.00
IUUC-Lch-050329	Latimeria chalumnae	50.43	5.00e-106	377.00
IUUC-Laf-053777	Loxodonta africana	73.73	0.00e+00	669.00
IUUC-Mcc-055771	Macaca mulatta	94.08	0.00e+00	864.00
IUUC-Meu-056584	Macropus eugenii	47.37	1.00e-84	306.00
IUUC-Mga-059818	Meleagris gallopavo	54.66	2.00e-121	428.00
IUUC-Mmr-060639	Microcebus murinus	76.22	8.00e-164	569.00
IUUC-Mdo-062321	Monodelphis domestica	56.74	2.00e-137	482.00
IUUC-Mpu-066849	Mustela putorius furo	74.88	6.00e-179	620.00
IUUC-Mlu-067238	Myotis lucifugus	67.13	4.00e-172	597.00
IUUC-Ont-071230	Oreochromis niloticus	44.32	1.00e-83	303.00
IUUC-Oan-072698	Ornithorhynchus anatinus	59.34	2.00e-141	495.00
IUUC-Ocu-074219	Oryctolagus cuniculus	78.28	2.00e-175	608.00
IUUC-Oga-087913	Otolemur garnettii	71.90	0.00e+00	635.00
IUUC-Oar-089977	Ovis aries	77.60	6.00e-179	620.00
IUUC-Ptr-090876	Pan troglodytes	98.73	0.00e+00	917.00
IUUC-Pan-091936	Papio anubis	94.64	4.00e-140	490.00
IUUC-Psi-093015	Pelodiscus sinensis	53.20	1.00e-76	279.00
IUUC-Pma-094552	Petromyzon marinus	33.33	1.00e-30	125.00
IUUC-Pfo-096240	Poecilia formosa	42.95	7.00e-77	282.00
IUUC-Pab-097983	Pongo abelii	85.81	0.00e+00	775.00
IUUC-Pca-100752	Procavia capensis	60.95	1.00e-144	506.00
IUUC-Pva-102199	Pteropus vampyrus	66.44	6.00e-173	600.00
IUUC-Rno-106062	Rattus norvegicus	69.40	7.00e-173	600.00
IUUC-Sar-113167	Sorex araneus	49.64	1.00e-33	137.00
IUUC-Ssc-116089	Sus scrofa	74.15	2.00e-179	622.00
IUUC-Tbe-127860	Tupaia belangeri	65.34	8.00e-168	583.00
IUUC-Ttr-129152	Tursiops truncatus	74.74	2.00e-172	598.00
IUUC-Vpa-130745	Vicugna pacos	67.18	8.00e-176	610.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence