iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000172175.12	ENST00000348428.7	ENSP00000319279.4
ENSG00000172175.12	ENST00000345724.7	ENSP00000304161.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	18287044

Organism

Homo sapiens

Functional Description
(View)

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Protein Sequence
(Fasta)

MSLLGDPLQA LPPSAAPTGP LLAPPAGATL NRLREPLLRR LSELLDQAPE GRGWRRLAEL 60
AGSRGRLRLS CLDLEQCSLK VLEPEGSPSL CLLKLMGEKG CTVTELSDFL QAMEHTEVLQ 120

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Nucleotide Sequence
(Fasta)

CGAGGCTCCG TGCCCCGCCC CCCGGGTGCC CCGCCCCTTT GCGCGGCTGG CGCGGCCAGC 60
AGGCCAGGCT CCCCTCGGCA AACCTGTCTA ATTGGGGCGG GGAGCGGAGC TTCCTCCTCT 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0393--Immunoglobulin domain
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR029030--Caspase-like_dom
IPR011029--DEATH-like_dom
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003599--Ig_sub
IPR003598--Ig_sub2
IPR033540--MALT1
IPR001309--Pept_C14_p20

PROSITE

PS50208--CASPASE_P20
PS50835--IG_LIKE

Pfam

PF13895--Ig_2

SMART

SM00409--IG
SM00408--IGc2

Gene Ontology

GO:0032449--C:CBM complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0008233--F:peptidase activity
GO:0043621--F:protein self-association
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0001923--P:B-1 B cell differentiation
GO:0006952--P:defense response
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0045087--P:innate immune response
GO:0043066--P:negative regulation of apoptotic process
GO:0051168--P:nuclear export
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032743--P:positive regulation of interleukin-2 production
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0031398--P:positive regulation of protein ubiquitination
GO:0050870--P:positive regulation of T cell activation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0051259--P:protein oligomerization
GO:0006508--P:proteolysis
GO:0042981--P:regulation of apoptotic process
GO:0050856--P:regulation of T cell receptor signaling pathway
GO:0009620--P:response to fungus
GO:0002237--P:response to molecule of bacterial origin
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0042098--P:T cell proliferation
GO:0050852--P:T cell receptor signaling pathway

KEGG

hsa:10892

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003814	Anas platyrhynchos	69.63	0.00e+00	1058.00
IUUC-Aca-005192	Anolis carolinensis	63.89	0.00e+00	746.00
IUUC-Aly-005742	Arabidopsis lyrata	31.58	2.60e-02	33.10
IUUC-Ame-010608	Astyanax mexicanus	55.88	0.00e+00	806.00
IUUC-Bgr-012182	Blumeria graminis	27.64	1.10e-01	31.20
IUUC-Bta-012436	Bos taurus	90.33	0.00e+00	1411.00
IUUC-Cel-018688	Caenorhabditis elegans	26.42	3.00e-42	166.00
IUUC-Cja-018945	Callithrix jacchus	85.48	0.00e+00	1289.00
IUUC-Cfa-020245	Canis familiaris	92.37	0.00e+00	1424.00
IUUC-Cpo-022400	Cavia porcellus	89.11	0.00e+00	1420.00
IUUC-Csa-023556	Chlorocebus sabaeus	99.18	0.00e+00	1442.00
IUUC-Cho-024489	Choloepus hoffmanni	87.43	1.00e-170	593.00
IUUC-Csv-026274	Ciona savignyi	31.29	3.00e-09	55.80
IUUC-Dre-028666	Danio rerio	54.25	0.00e+00	770.00
IUUC-Dno-029397	Dasypus novemcinctus	90.51	0.00e+00	1428.00
IUUC-Dse-031279	Dothistroma septosporum	22.93	1.00e-03	37.70
IUUC-Ete-032600	Echinops telfairi	70.56	2.00e-145	509.00
IUUC-Eca-033475	Equus caballus	92.62	0.00e+00	1422.00
IUUC-Eeu-034788	Erinaceus europaeus	86.33	0.00e+00	1363.00
IUUC-Fca-035687	Felis catus	89.44	0.00e+00	1400.00
IUUC-Fal-037432	Ficedula albicollis	65.95	0.00e+00	992.00
IUUC-Gmo-038533	Gadus morhua	52.88	0.00e+00	690.00
IUUC-Gga-040429	Gallus gallus	70.42	0.00e+00	1097.00
IUUC-Gac-041963	Gasterosteus aculeatus	58.65	0.00e+00	837.00
IUUC-Ggo-045328	Gorilla gorilla	99.15	0.00e+00	1546.00
IUUC-Itr-048424	Ictidomys tridecemlineatus	93.21	0.00e+00	903.00
IUUC-Lch-049486	Latimeria chalumnae	67.26	0.00e+00	1002.00
IUUC-Loc-051782	Lepisosteus oculatus	59.95	0.00e+00	897.00
IUUC-Laf-053612	Loxodonta africana	89.45	0.00e+00	1459.00
IUUC-Mcc-054811	Macaca mulatta	96.48	0.00e+00	1498.00
IUUC-Meu-056602	Macropus eugenii	90.91	5.00e-130	458.00
IUUC-Mtr-058549	Medicago truncatula	23.19	8.00e-03	35.40
IUUC-Mmr-060713	Microcebus murinus	93.15	0.00e+00	1525.00
IUUC-Mdo-062385	Monodelphis domestica	78.99	0.00e+00	1283.00
IUUC-Mpu-065996	Mustela putorius furo	91.89	0.00e+00	1327.00
IUUC-Mlu-067627	Myotis lucifugus	88.65	0.00e+00	1352.00
IUUC-Nle-069583	Nomascus leucogenys	99.15	0.00e+00	1547.00
IUUC-Opr-070641	Ochotona princeps	87.66	0.00e+00	1033.00
IUUC-Ont-071363	Oreochromis niloticus	59.14	0.00e+00	823.00
IUUC-Oan-073407	Ornithorhynchus anatinus	80.66	0.00e+00	743.00
IUUC-Oba-075778	Oryza barthii	29.27	1.40e+00	28.10
IUUC-Ola-086554	Oryzias latipes	58.12	0.00e+00	791.00
IUUC-Oga-088538	Otolemur garnettii	85.60	0.00e+00	1282.00
IUUC-Oar-090012	Ovis aries	89.75	0.00e+00	1341.00
IUUC-Ptr-090677	Pan troglodytes	99.51	0.00e+00	1554.00
IUUC-Pan-092262	Papio anubis	99.03	0.00e+00	1553.00
IUUC-Psi-093186	Pelodiscus sinensis	70.03	0.00e+00	1016.00
IUUC-Pfo-097154	Poecilia formosa	57.83	0.00e+00	796.00
IUUC-Pab-098695	Pongo abelii	93.20	0.00e+00	1423.00
IUUC-Pca-100956	Procavia capensis	94.70	0.00e+00	747.00
IUUC-Pva-102917	Pteropus vampyrus	82.77	0.00e+00	841.00
IUUC-Rno-105680	Rattus norvegicus	88.65	0.00e+00	1302.00
IUUC-Sha-107559	Sarcophilus harrisii	83.00	0.00e+00	1261.00
IUUC-Sar-113054	Sorex araneus	85.99	0.00e+00	787.00
IUUC-Ssc-116110	Sus scrofa	88.81	0.00e+00	1329.00
IUUC-Tgu-116542	Taeniopygia guttata	73.29	0.00e+00	1016.00
IUUC-Tru-118019	Takifugu rubripes	57.37	0.00e+00	783.00
IUUC-Tsy-119591	Tarsius syrichta	81.85	0.00e+00	1166.00
IUUC-Tbe-128075	Tupaia belangeri	64.41	9.00e-120	424.00
IUUC-Ttr-128309	Tursiops truncatus	84.56	0.00e+00	1253.00
IUUC-Vpa-130271	Vicugna pacos	90.12	0.00e+00	931.00
IUUC-Xtr-132554	Xenopus tropicalis	60.50	0.00e+00	902.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence