iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000196151.10	ENST00000359774.8	ENSP00000352820.4
ENSG00000196151.10	ENST00000358147.8	ENSP00000350866.4
ENSG00000196151.10	ENST00000409124.1	ENSP00000386891.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	8.60e-25	88.3	404	475
E3 adaptor/Cullin RING/DCX/DWD	8.80e-40	134.6	11	44
UBD/Beta-Prp	7.50e-53	181.3	7	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceens 73
           +p+ef+CpI+ elM+dPv++++G++y+++++e w++++++t+P+t+  l +  l+Pn tl+  i++w+e+++
   Q: 404  IPDEFICPITRELMKDPVIASDGYSYEKEAMENWISKKKRTSPMTNLVLPSAVLTPNRTLKMAINRWLETHQ 475
           8********************************************************************997 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           H d+v+c+af  s  ll+++s D+ti++++lr+++ 
   Q: 11   HGDDVNCCAFsfS--LLATCSLDKTIRLYSLRDFTE 44
           9*********644..9***************99875 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           tl +h ++v +c +f  + sllat s d+ti+++++++ +    + l+ h+ +v +++fsp+g il+++s+D+t  +w+ ++g+++ ++++ 
   Q: 7    TLADHGDDV-NCCAF--SFSLLATCSLDKTIRLYSLRDFTElpHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQP 95
           566666655.55889..99******************9666667889******************************************976 PP
   S: 94   e.dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
           + + v+ ++fsp++  l+sG +d t+ +w+ ++++ ++ + s++dg+    +++p+g+ +v+Gs  + + +Wd   +++l+  +  h+  ++
   Q: 96   SgSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYR-CGSVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDD-KMRCLHSEKA-HDLGIT 184
           5267*********************************9.*********************************98.5678888877.****** PP
   S: 185  slsfdsng..........kelvsgsldgtvklwdlq 210
           + +f+s+           ++l+s+++d +vk+w ++
   Q: 185  CCDFSSQPvsdgeqglqfFRLASCGQDCQVKIWIVS 220
           ***99988999999*******************665 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MVKLIHTLAD HGDDVNCCAF SFSLLATCSL DKTIRLYSLR DFTELPHSPL KFHTYAVHCC 60
CFSPSGHILA SCSTDGTTVL WNTENGQMLA VMEQPSGSPV RVCQFSPDST CLASGAADGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCCTACT CCCTCCGCTC TGGGTCACAG CGGGCGTTCG GGGGGCGGGG CCTGTTCCCT 60
CCGCTCTGGG TCCCCGCGGG CGTTCGGGGG CGGGGCCTGT TCCCTCTGCT CTGGGTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR001660--SAM
IPR013761--SAM/pointed
IPR003613--Ubox_domain
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50105--SAM_DOMAIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07647--SAM_2
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00454--SAM
SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

hsa:151525

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000612	Aegilops tauschii	53.03	5.00e-17	83.60
IUUC-Aml-001614	Ailuropoda melanoleuca	93.49	0.00e+00	934.00
IUUC-Apl-003529	Anas platyrhynchos	75.84	0.00e+00	761.00
IUUC-Aca-004257	Anolis carolinensis	70.64	0.00e+00	699.00
IUUC-Ame-011357	Astyanax mexicanus	51.57	3.00e-116	412.00
IUUC-Bta-013032	Bos taurus	88.26	0.00e+00	882.00
IUUC-Cja-018743	Callithrix jacchus	95.80	0.00e+00	948.00
IUUC-Cfa-021197	Canis familiaris	92.23	0.00e+00	926.00
IUUC-Cpo-022279	Cavia porcellus	90.76	0.00e+00	906.00
IUUC-Csa-023954	Chlorocebus sabaeus	97.90	0.00e+00	963.00
IUUC-Cho-025083	Choloepus hoffmanni	74.60	2.00e-159	555.00
IUUC-Cin-025786	Ciona intestinalis	34.68	9.00e-79	287.00
IUUC-Dre-028087	Danio rerio	56.38	4.00e-142	498.00
IUUC-Dno-028919	Dasypus novemcinctus	93.28	0.00e+00	929.00
IUUC-Dor-031112	Dipodomys ordii	89.92	0.00e+00	891.00
IUUC-Ete-032405	Echinops telfairi	90.38	0.00e+00	647.00
IUUC-Eca-033254	Equus caballus	90.34	0.00e+00	901.00
IUUC-Eeu-034545	Erinaceus europaeus	86.76	0.00e+00	837.00
IUUC-Fca-035482	Felis catus	93.28	0.00e+00	929.00
IUUC-Fal-036976	Ficedula albicollis	63.15	4.00e-167	581.00
IUUC-Gmo-039213	Gadus morhua	54.83	7.00e-137	480.00
IUUC-Gga-040561	Gallus gallus	74.63	0.00e+00	748.00
IUUC-Gac-041471	Gasterosteus aculeatus	57.77	5.00e-141	494.00
IUUC-Ggo-045503	Gorilla gorilla	99.58	0.00e+00	984.00
IUUC-Itr-048214	Ictidomys tridecemlineatus	91.51	0.00e+00	719.00
IUUC-Loc-052307	Lepisosteus oculatus	59.33	3.00e-166	578.00
IUUC-Laf-053587	Loxodonta africana	92.65	0.00e+00	920.00
IUUC-Mcc-055679	Macaca mulatta	98.32	0.00e+00	972.00
IUUC-Meu-055962	Macropus eugenii	71.64	0.00e+00	658.00
IUUC-Mga-059652	Meleagris gallopavo	74.21	0.00e+00	749.00
IUUC-Mmr-060943	Microcebus murinus	91.42	0.00e+00	905.00
IUUC-Mdo-062592	Monodelphis domestica	83.51	0.00e+00	840.00
IUUC-Mmu-063577	Mus musculus	82.14	0.00e+00	818.00
IUUC-Mpu-066422	Mustela putorius furo	92.02	0.00e+00	919.00
IUUC-Mlu-067250	Myotis lucifugus	91.60	0.00e+00	910.00
IUUC-Nle-069517	Nomascus leucogenys	98.95	0.00e+00	977.00
IUUC-Opr-070776	Ochotona princeps	91.39	0.00e+00	894.00
IUUC-Ont-071821	Oreochromis niloticus	56.90	3.00e-149	521.00
IUUC-Oan-073706	Ornithorhynchus anatinus	83.16	0.00e+00	833.00
IUUC-Ocu-074766	Oryctolagus cuniculus	84.58	0.00e+00	817.00
IUUC-Ola-086531	Oryzias latipes	56.84	3.00e-145	508.00
IUUC-Oga-088388	Otolemur garnettii	90.97	0.00e+00	907.00
IUUC-Oar-089748	Ovis aries	88.89	0.00e+00	882.00
IUUC-Ptr-090616	Pan troglodytes	99.37	0.00e+00	976.00
IUUC-Pan-091769	Papio anubis	97.97	0.00e+00	695.00
IUUC-Psi-093334	Pelodiscus sinensis	78.57	0.00e+00	738.00
IUUC-Pma-094383	Petromyzon marinus	48.25	5.00e-132	464.00
IUUC-Pfo-096801	Poecilia formosa	55.53	2.00e-145	508.00
IUUC-Pab-098139	Pongo abelii	98.46	0.00e+00	793.00
IUUC-Pca-100523	Procavia capensis	77.10	0.00e+00	741.00
IUUC-Pva-102286	Pteropus vampyrus	90.97	0.00e+00	881.00
IUUC-Rno-104831	Rattus norvegicus	83.82	0.00e+00	837.00
IUUC-Sha-107499	Sarcophilus harrisii	84.66	0.00e+00	849.00
IUUC-Sar-113389	Sorex araneus	87.18	0.00e+00	848.00
IUUC-Tgu-116769	Taeniopygia guttata	73.32	0.00e+00	731.00
IUUC-Tru-118774	Takifugu rubripes	53.29	1.00e-139	489.00
IUUC-Tsy-119595	Tarsius syrichta	81.31	0.00e+00	654.00
IUUC-Tni-119850	Tetraodon nigroviridis	56.99	5.00e-147	514.00
IUUC-Tur-126683	Triticum urartu	51.52	6.00e-17	83.20
IUUC-Tbe-127938	Tupaia belangeri	82.95	1.00e-147	515.00
IUUC-Ttr-128193	Tursiops truncatus	91.27	0.00e+00	775.00
IUUC-Vpa-130275	Vicugna pacos	92.23	0.00e+00	915.00
IUUC-Xtr-131982	Xenopus tropicalis	61.47	1.00e-170	592.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence