iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-12	47.3	373	428

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++v ++ydy aq  ++L +++Gd+v+v+   e de Wl+g  +  g+ G+fP+ Fv+ +
   Q: 373  LYQVVAQYDYRAQRPEDLDFRQGDTVDVL--CEVDEAWLEG--HRDGRVGIFPKCFVVPA 428
           6899*************************..9*********..89************875 PP

Organism

Rattus norvegicus

Functional Description
(View)

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3 (By similarity).

Protein Sequence
(Fasta)

MSSLGDQIRD WHRGVLAVAR EDWDSALCFF SDVREPLAKM YFNMGCVHLM AGDPEAALRA 60
FDQAVTKDTC MAVGFLQRGV ANFQLQRLQE AVSDFQLALA QLRGNAAIDY TQLGLDFKLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCTCTC TAGGGGATCA GATACGGGAC TGGCACCGGG GCGTACTGGC CGTAGCACGC 60
GAAGACTGGG ACTCTGCACT GTGCTTCTTT TCAGATGTCC GGGAGCCGCT GGCTAAGATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0802--TPR repeat

Interpro

IPR000270--PB1_dom
IPR001452--SH3_domain
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat

PROSITE

PS51745--PB1
PS50002--SH3
PS50005--TPR
PS50293--TPR_REGION

Pfam

PF00564--PB1
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00666--PB1
SM00326--SH3
SM00028--TPR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043020--C:NADPH oxidase complex
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0010310--P:regulation of hydrogen peroxide metabolic process
GO:0060263--P:regulation of respiratory burst
GO:0006801--P:superoxide metabolic process

KEGG

rno:311793

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001888	Ailuropoda melanoleuca	38.79	1.00e-39	157.00
IUUC-Apl-003838	Anas platyrhynchos	47.54	4.00e-46	179.00
IUUC-Aca-005068	Anolis carolinensis	38.64	4.00e-42	165.00
IUUC-Ame-011744	Astyanax mexicanus	38.33	5.00e-39	155.00
IUUC-Bta-013236	Bos taurus	69.23	3.00e-85	308.00
IUUC-Cja-018958	Callithrix jacchus	37.85	2.00e-38	153.00
IUUC-Cfa-020476	Canis familiaris	40.19	1.00e-41	164.00
IUUC-Cpo-022423	Cavia porcellus	56.96	2.00e-135	476.00
IUUC-Csa-023576	Chlorocebus sabaeus	59.04	5.00e-147	514.00
IUUC-Dre-028554	Danio rerio	41.44	1.00e-43	171.00
IUUC-Dno-029212	Dasypus novemcinctus	40.19	1.00e-37	151.00
IUUC-Dor-030205	Dipodomys ordii	37.78	1.00e-24	107.00
IUUC-Ete-032956	Echinops telfairi	42.27	1.00e-46	180.00
IUUC-Eca-033997	Equus caballus	59.83	3.00e-147	514.00
IUUC-Eeu-035239	Erinaceus europaeus	61.76	4.00e-68	251.00
IUUC-Fca-036178	Felis catus	39.25	4.00e-37	149.00
IUUC-Fal-037602	Ficedula albicollis	46.48	8.00e-54	204.00
IUUC-Gmo-039472	Gadus morhua	39.17	3.00e-41	162.00
IUUC-Gga-041173	Gallus gallus	46.01	2.00e-43	170.00
IUUC-Gac-042198	Gasterosteus aculeatus	42.29	7.00e-48	184.00
IUUC-Ggo-045435	Gorilla gorilla	37.85	2.00e-37	150.00
IUUC-Hsa-046273	Homo sapiens	39.72	2.00e-36	146.00
IUUC-Itr-048999	Ictidomys tridecemlineatus	60.97	6.00e-143	500.00
IUUC-Lch-049624	Latimeria chalumnae	45.83	9.00e-54	204.00
IUUC-Loc-052742	Lepisosteus oculatus	40.83	1.00e-50	194.00
IUUC-Laf-053863	Loxodonta africana	40.65	3.00e-38	153.00
IUUC-Mcc-055758	Macaca mulatta	65.48	9.00e-87	313.00
IUUC-Meu-056768	Macropus eugenii	27.73	9.00e-20	91.70
IUUC-Mga-060085	Meleagris gallopavo	47.42	7.00e-45	175.00
IUUC-Mmr-060852	Microcebus murinus	40.87	3.00e-40	159.00
IUUC-Mdo-062802	Monodelphis domestica	48.12	5.00e-111	394.00
IUUC-Mmu-063940	Mus musculus	86.32	0.00e+00	698.00
IUUC-Mpu-066159	Mustela putorius furo	39.25	1.00e-40	161.00
IUUC-Mlu-067637	Myotis lucifugus	41.36	3.00e-40	159.00
IUUC-Nle-068999	Nomascus leucogenys	40.19	3.00e-37	149.00
IUUC-Opr-070374	Ochotona princeps	48.82	2.00e-31	130.00
IUUC-Ont-071710	Oreochromis niloticus	38.57	3.00e-42	166.00
IUUC-Oan-072977	Ornithorhynchus anatinus	56.86	3.00e-12	66.60
IUUC-Ocu-073762	Oryctolagus cuniculus	42.52	2.00e-38	153.00
IUUC-Ola-086389	Oryzias latipes	39.58	1.00e-44	174.00
IUUC-Oga-088950	Otolemur garnettii	67.29	4.00e-166	577.00
IUUC-Oar-089752	Ovis aries	64.88	1.00e-68	253.00
IUUC-Ptr-091639	Pan troglodytes	39.25	3.00e-35	142.00
IUUC-Pan-092537	Papio anubis	67.93	8.00e-87	314.00
IUUC-Psi-093082	Pelodiscus sinensis	48.37	1.00e-59	223.00
IUUC-Pfo-097064	Poecilia formosa	38.33	3.00e-45	176.00
IUUC-Pab-098199	Pongo abelii	39.25	4.00e-36	145.00
IUUC-Pca-100910	Procavia capensis	34.07	2.00e-32	134.00
IUUC-Pva-103116	Pteropus vampyrus	56.02	1.00e-122	432.00
IUUC-Sha-107541	Sarcophilus harrisii	44.84	3.00e-107	382.00
IUUC-Ssc-115353	Sus scrofa	59.00	1.00e-150	525.00
IUUC-Tgu-116783	Taeniopygia guttata	41.82	4.00e-44	172.00
IUUC-Tru-118473	Takifugu rubripes	40.37	2.00e-47	183.00
IUUC-Tsy-119120	Tarsius syrichta	43.18	3.00e-17	83.20
IUUC-Tni-119900	Tetraodon nigroviridis	39.73	3.00e-44	172.00
IUUC-Tbe-127725	Tupaia belangeri	34.57	2.00e-16	80.10
IUUC-Ttr-128628	Tursiops truncatus	45.20	3.00e-94	338.00
IUUC-Xtr-132656	Xenopus tropicalis	38.87	6.00e-45	175.00
IUUC-Xma-134150	Xiphophorus maculatus	38.75	3.00e-45	176.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence