iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000007313.2	ENSNLET00000009344.1	ENSNLEP00000008923.1
ENSNLEG00000007313.2	ENSNLET00000032119.1	ENSNLEP00000023745.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.40e-59	199.2	162	648

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC++ +v+Q+L+++pe+r+l+l+     +  e+++    ++++  ++++lq lf+ ++ s++k v+p++ l+ lk + ++ 
   Q: 162  VGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSyslpqNVLENCRSH-TEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRS- 248
           6******************************97665555555543.478888*******************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           s+ +qqD++Ef++ lld le++++                     + +++ +k+++++++lF g++ ++ + +        +e+f +++
   Q: 249  SEEQQQDVSEFTHKLLDWLEDAFQL------------------AVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFC--NNETFGQYP 317
           99*********************22..................23467899****************99998665555..5899***** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e  +e    +  +   ++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 318  LQVNGYR-----NLDECLEGAMVEGDVE----LLPSD--HSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMD 395
           *******.....99****7665555555....55554..556778899***************************************** PP
   S: 263  pfcts.................................................................................... 267
           +++ +                                                                                    
   Q: 396  RYMYRskelirnkrecirklkeeikilqqkleryvkygsgparfplpdmlkyviefastkpasescppesdthmtlplssvhcpvsdqt 484
           *9999778888888888888888888777777777777777777777777777777777777777777777777777777777666665 PP
   S: 268  ....peekqke.............................................................................. 274
               +     +                                                                              
   Q: 485  skesT-----Stesssqdvestfsspedslhkskpltssrssmempsqpaprtvtdeeinfvktclqrwrseieqdiqdlknciasttq 568
           55550.....0555556666677777777777777778888888888888888888888888889999999999999999999999999 PP
   S: 275  ............kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                       ++ Y+L+av+vH+G+++ GHY+ay++n+ ++ Wl+++D +Vte+++eev++++       +aY+l+Y 
   Q: 569  tieqmycdpllrQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQsWLKYNDISVTESSWEEVERDSYgglrnVSAYCLMYI 648
           99999******9***************************88888*******************8879************6 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MTAELQQDDA AGAADGHGSS CQMLLNQLRE ITGIQDPSFL HEALKASNGD ITQAVSLLTD 60
ERVKEPSQDT VATEPSEVEG SAANKEVLAK VIDLTHDNKD DLQAAIALSL LESPKIQADG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCGGCTG CGGCGGGAGA CGGGTGACCC GCGGCTGGGC GCCTCGGCCA TGACTGCCGA 60
GCTGCAGCAG GACGACGCGG CCGGCGCGGC AGACGGCCAC GGCTCGGTGG GCTCCGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	94.36	0.00e+00	2021.00
IUUC-Apl-004010	Anas platyrhynchos	70.23	0.00e+00	1476.00
IUUC-Aca-004741	Anolis carolinensis	58.44	0.00e+00	846.00
IUUC-Acl-008164	Aspergillus clavatus	32.71	5.00e-12	67.40
IUUC-Ang-009577	Aspergillus niger	36.36	2.00e-11	65.10
IUUC-Ate-010275	Aspergillus terreus	35.24	4.00e-11	63.90
IUUC-Bta-013377	Bos taurus	92.98	0.00e+00	1959.00
IUUC-Cja-019977	Callithrix jacchus	98.52	0.00e+00	2076.00
IUUC-Cfa-020378	Canis familiaris	93.47	0.00e+00	1389.00
IUUC-Cpo-021817	Cavia porcellus	90.98	0.00e+00	1941.00
IUUC-Csa-023446	Chlorocebus sabaeus	99.09	0.00e+00	1467.00
IUUC-Cho-024717	Choloepus hoffmanni	84.58	0.00e+00	1227.00
IUUC-Csv-025911	Ciona savignyi	35.36	8.00e-142	498.00
IUUC-Cme-027167	Cyanidioschyzon merolae	33.00	9.00e-16	79.30
IUUC-Dre-028105	Danio rerio	56.32	0.00e+00	707.00
IUUC-Dno-029559	Dasypus novemcinctus	91.37	0.00e+00	1513.00
IUUC-Dor-030955	Dipodomys ordii	90.92	0.00e+00	1938.00
IUUC-Ete-032828	Echinops telfairi	81.82	0.00e+00	1172.00
IUUC-Eca-034300	Equus caballus	94.35	0.00e+00	1948.00
IUUC-Eeu-034458	Erinaceus europaeus	89.51	0.00e+00	1725.00
IUUC-Fca-035753	Felis catus	94.07	0.00e+00	2012.00
IUUC-Fal-037062	Ficedula albicollis	64.12	0.00e+00	884.00
IUUC-Gmo-039593	Gadus morhua	52.05	0.00e+00	1031.00
IUUC-Gga-040878	Gallus gallus	64.64	0.00e+00	1321.00
IUUC-Gac-041867	Gasterosteus aculeatus	54.41	0.00e+00	1107.00
IUUC-Ggo-045384	Gorilla gorilla	98.98	0.00e+00	2080.00
IUUC-Hsa-046277	Homo sapiens	99.16	0.00e+00	2086.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	87.88	0.00e+00	1156.00
IUUC-Lch-049692	Latimeria chalumnae	66.32	0.00e+00	1398.00
IUUC-Laf-053808	Loxodonta africana	88.90	0.00e+00	1848.00
IUUC-Mcc-055473	Macaca mulatta	99.09	0.00e+00	1467.00
IUUC-Meu-056416	Macropus eugenii	75.31	0.00e+00	1521.00
IUUC-Mga-060011	Meleagris gallopavo	67.67	0.00e+00	1401.00
IUUC-Mmr-060720	Microcebus murinus	93.28	0.00e+00	1939.00
IUUC-Mdo-061955	Monodelphis domestica	85.44	0.00e+00	1316.00
IUUC-Mmu-063870	Mus musculus	87.72	0.00e+00	1889.00
IUUC-Mpu-066454	Mustela putorius furo	91.73	0.00e+00	1333.00
IUUC-Mlu-067487	Myotis lucifugus	88.82	0.00e+00	1868.00
IUUC-Opr-070888	Ochotona princeps	98.19	4.00e-162	565.00
IUUC-Ocu-074523	Oryctolagus cuniculus	90.96	0.00e+00	1934.00
IUUC-Ola-086393	Oryzias latipes	54.55	0.00e+00	1107.00
IUUC-Oga-088618	Otolemur garnettii	94.90	0.00e+00	1990.00
IUUC-Oar-089848	Ovis aries	84.58	0.00e+00	1830.00
IUUC-Ptr-091630	Pan troglodytes	98.91	0.00e+00	1583.00
IUUC-Psi-093422	Pelodiscus sinensis	65.61	0.00e+00	1400.00
IUUC-Pma-094250	Petromyzon marinus	51.89	1.00e-72	265.00
IUUC-Pfo-096466	Poecilia formosa	55.27	0.00e+00	747.00
IUUC-Pab-098337	Pongo abelii	99.07	0.00e+00	2085.00
IUUC-Pca-100901	Procavia capensis	78.15	0.00e+00	1613.00
IUUC-Pva-102226	Pteropus vampyrus	88.91	0.00e+00	1742.00
IUUC-Rno-105735	Rattus norvegicus	84.60	0.00e+00	1872.00
IUUC-Sha-107489	Sarcophilus harrisii	87.80	0.00e+00	1867.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	34.57	7.00e-09	56.60
IUUC-Tgu-116609	Taeniopygia guttata	69.19	0.00e+00	1420.00
IUUC-Tru-117807	Takifugu rubripes	54.29	0.00e+00	1088.00
IUUC-Tsy-118971	Tarsius syrichta	88.83	0.00e+00	1251.00
IUUC-Tni-119983	Tetraodon nigroviridis	54.48	0.00e+00	1103.00
IUUC-Ttr-128887	Tursiops truncatus	88.72	0.00e+00	1858.00
IUUC-Vpa-130614	Vicugna pacos	92.41	0.00e+00	1504.00
IUUC-Xtr-132436	Xenopus tropicalis	62.62	0.00e+00	1297.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence