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Tag Content
iUUCD ID IUUC-Fal-037336
Ensembl Protein ID ENSFALP00000014424.1
UniProt Accession U3KHC0; U3KHC0_FICAL
Genbank Protein ID ENSFALP00000014424
Protein Name Uncharacterized protein
Genbank Nucleotide ID AGTO01000672
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSFALG00000013824.1 ENSFALT00000014484.1 ENSFALP00000014424.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.10e-128 429.1 391 723
Active Site
Position(s) Description Evidence
692 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 391  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 478
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+nipVt+eNk+eYv+l+v+
   Q: 479  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNIPVTEENKKEYVRLYVN 563
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqFv
   Q: 564  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQFV 651
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 652  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 723
           ***************************99999**************************************76 PP
   
Organism Ficedula albicollis
Protein Sequence
(Fasta)
MVLKFLYLLF CFAVLCAKNL AKKDFFRLPD PFAKIVVDGS GQCHSTDTVK NTLDPKWNQH 60
YDLYVGKTDS ITISVWNHKK IHKKQGAGFL GCVRLLSNAI SRLKDTGYQR LDLCKLNPTD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Fal-037336|E3,HECT|Ficedula albicollis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TACCAGAAAG CTTCTTTTTT ATGGTTTTAA AATTCCTTTA TCTGCTTTTT TGTTTTGCAG 60
TATTATGTGC CAAGAATCTC GCAAAGAAAG ATTTCTTCAG TAAGTATGTC CTAATTGTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Fal-037336|E3,HECT|Ficedula albicollis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 91.24 0.00e+00 1379.00
IUUC-Apl-004155 Anas platyrhynchos 95.66 0.00e+00 1434.00
IUUC-Aca-005238 Anolis carolinensis 96.08 0.00e+00 1421.00
IUUC-Ame-010901 Astyanax mexicanus 90.92 0.00e+00 1352.00
IUUC-Bta-013221 Bos taurus 90.61 0.00e+00 1337.00
IUUC-Cja-018985 Callithrix jacchus 93.00 0.00e+00 1407.00
IUUC-Cfa-020568 Canis familiaris 92.26 0.00e+00 1389.00
IUUC-Cpo-022531 Cavia porcellus 92.46 0.00e+00 1398.00
IUUC-Csa-024145 Chlorocebus sabaeus 96.78 0.00e+00 1425.00
IUUC-Cho-024963 Choloepus hoffmanni 75.12 0.00e+00 882.00
IUUC-Dre-028341 Danio rerio 90.50 0.00e+00 1346.00
IUUC-Dno-029705 Dasypus novemcinctus 92.71 0.00e+00 1375.00
IUUC-Eca-034125 Equus caballus 92.98 0.00e+00 1402.00
IUUC-Fca-035905 Felis catus 94.91 0.00e+00 1401.00
IUUC-Gmo-039486 Gadus morhua 80.30 0.00e+00 860.00
IUUC-Gga-040218 Gallus gallus 96.97 0.00e+00 1441.00
IUUC-Gac-041707 Gasterosteus aculeatus 84.76 0.00e+00 1248.00
IUUC-Ggo-045408 Gorilla gorilla 87.35 0.00e+00 1298.00
IUUC-Hsa-045878 Homo sapiens 93.14 0.00e+00 1407.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 93.24 0.00e+00 1402.00
IUUC-Loc-052628 Lepisosteus oculatus 85.49 0.00e+00 1338.00
IUUC-Laf-053644 Loxodonta africana 91.37 0.00e+00 1359.00
IUUC-Mcc-055479 Macaca mulatta 88.01 0.00e+00 1260.00
IUUC-Mga-059723 Meleagris gallopavo 94.85 0.00e+00 1415.00
IUUC-Mdo-063005 Monodelphis domestica 96.93 0.00e+00 1429.00
IUUC-Mmu-063634 Mus musculus 95.54 0.00e+00 1386.00
IUUC-Mpu-065898 Mustela putorius furo 95.96 0.00e+00 1400.00
IUUC-Mlu-067584 Myotis lucifugus 92.50 0.00e+00 1402.00
IUUC-Nle-069033 Nomascus leucogenys 93.39 0.00e+00 1405.00
IUUC-Ont-072265 Oreochromis niloticus 82.57 0.00e+00 1258.00
IUUC-Oan-073621 Ornithorhynchus anatinus 92.14 0.00e+00 1413.00
IUUC-Ocu-073960 Oryctolagus cuniculus 91.92 0.00e+00 1375.00
IUUC-Oga-088579 Otolemur garnettii 93.14 0.00e+00 1406.00
IUUC-Oar-090396 Ovis aries 90.25 0.00e+00 1329.00
IUUC-Ptr-091624 Pan troglodytes 93.14 0.00e+00 1407.00
IUUC-Pan-092479 Papio anubis 93.14 0.00e+00 1406.00
IUUC-Pfo-097203 Poecilia formosa 85.00 0.00e+00 1271.00
IUUC-Pab-097540 Pongo abelii 92.68 0.00e+00 1336.00
IUUC-Pca-100379 Procavia capensis 71.12 8.00e-175 607.00
IUUC-Rno-105396 Rattus norvegicus 95.54 0.00e+00 1387.00
IUUC-Sha-107216 Sarcophilus harrisii 93.04 0.00e+00 1419.00
IUUC-Ssc-116413 Sus scrofa 94.71 0.00e+00 1368.00
IUUC-Tgu-116723 Taeniopygia guttata 95.68 0.00e+00 1419.00
IUUC-Tru-117843 Takifugu rubripes 82.54 0.00e+00 1251.00
IUUC-Tsy-119455 Tarsius syrichta 92.51 0.00e+00 1309.00
IUUC-Tni-120829 Tetraodon nigroviridis 79.44 0.00e+00 1194.00
IUUC-Tbe-127879 Tupaia belangeri 79.49 0.00e+00 1143.00
IUUC-Ttr-128423 Tursiops truncatus 91.89 0.00e+00 1323.00
IUUC-Xtr-132237 Xenopus tropicalis 87.97 0.00e+00 1336.00
Created Date 25-Jun-2017

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