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Tag Content
UUCD2 ID IUUC-Cfa-020346
UUCD1 version UUC-CaF-00202
Ensembl Protein ID ENSCAFP00000005356.3
UniProt Accession F6XFQ9; F6XFQ9_CANLF
Genbank Protein ID ENSCAFP00000005356
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAEX03008574
Gene Name HACE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000003592.3 ENSCAFT00000005785.3 ENSCAFP00000005356.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.00e-117 393.6 576 905
Active Site
Position(s) Description Evidence
876 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 576  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 661
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 662  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 747
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ ++t+y++gy++++p+iqwFwev+e+++ eer  +LqFvT
   Q: 748  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIRNTEYTSGYEREDPVIQWFWEVVEGITPEERVLLLQFVT 836
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 837  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 905
           ******************8888888868888********************************986555 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
MERAMEQLNR LTRSLRRART VELPDDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020346|E3,HECT|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGAGAG CGATGGAGCA GCTCAACCGC CTCACGCGCT CGCTGCGCCG CGCGCGCACC 60
GTGGAGCTGC CGGACGGTGA GCGGGGCGGG GGCCGGGCCG GGCCGGGCCG GGGCGGGGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020346|E3,HECT|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
Pfam

PF12796--Ank_2
PF00632--HECT
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00119--HECTc
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001490 Ailuropoda melanoleuca 99.23 0.00e+00 1883.00
IUUC-Apl-003400 Anas platyrhynchos 87.72 0.00e+00 1150.00
IUUC-Aca-005375 Anolis carolinensis 90.99 0.00e+00 1730.00
IUUC-Ame-011847 Astyanax mexicanus 84.66 0.00e+00 1640.00
IUUC-Bta-012831 Bos taurus 99.21 0.00e+00 1840.00
IUUC-Cja-019160 Callithrix jacchus 98.46 0.00e+00 1873.00
IUUC-Cpo-021766 Cavia porcellus 97.03 0.00e+00 1850.00
IUUC-Csa-023768 Chlorocebus sabaeus 98.35 0.00e+00 1873.00
IUUC-Cho-024688 Choloepus hoffmanni 93.85 0.00e+00 1177.00
IUUC-Cin-025417 Ciona intestinalis 50.63 9.00e-139 487.00
IUUC-Csv-025993 Ciona savignyi 44.00 0.00e+00 755.00
IUUC-Dre-027819 Danio rerio 85.53 0.00e+00 1628.00
IUUC-Dno-029027 Dasypus novemcinctus 97.27 0.00e+00 1843.00
IUUC-Dor-030327 Dipodomys ordii 90.15 0.00e+00 1628.00
IUUC-Ete-032966 Echinops telfairi 90.11 0.00e+00 1698.00
IUUC-Eca-034339 Equus caballus 98.90 0.00e+00 1882.00
IUUC-Eeu-034544 Erinaceus europaeus 70.69 0.00e+00 698.00
IUUC-Fca-035617 Felis catus 99.69 0.00e+00 1355.00
IUUC-Fal-036687 Ficedula albicollis 90.98 0.00e+00 1756.00
IUUC-Gmo-039508 Gadus morhua 87.70 0.00e+00 828.00
IUUC-Gga-040845 Gallus gallus 91.30 0.00e+00 1779.00
IUUC-Gac-041894 Gasterosteus aculeatus 85.23 0.00e+00 1586.00
IUUC-Ggo-044465 Gorilla gorilla 94.41 0.00e+00 1790.00
IUUC-Hsa-045731 Homo sapiens 98.35 0.00e+00 1875.00
IUUC-Itr-048716 Ictidomys tridecemlineatus 98.46 0.00e+00 1868.00
IUUC-Lch-050436 Latimeria chalumnae 89.40 0.00e+00 1686.00
IUUC-Loc-052287 Lepisosteus oculatus 84.75 0.00e+00 1657.00
IUUC-Laf-053846 Loxodonta africana 98.35 0.00e+00 1867.00
IUUC-Mcc-055845 Macaca mulatta 98.46 0.00e+00 1875.00
IUUC-Meu-056060 Macropus eugenii 97.69 0.00e+00 703.00
IUUC-Mga-059935 Meleagris gallopavo 93.78 0.00e+00 1758.00
IUUC-Mmr-060960 Microcebus murinus 98.90 0.00e+00 1882.00
IUUC-Mdo-061851 Monodelphis domestica 93.21 0.00e+00 1819.00
IUUC-Mmu-063657 Mus musculus 96.59 0.00e+00 1845.00
IUUC-Mpu-066161 Mustela putorius furo 99.75 0.00e+00 834.00
IUUC-Mlu-067354 Myotis lucifugus 96.69 0.00e+00 1799.00
IUUC-Nle-069112 Nomascus leucogenys 98.24 0.00e+00 1871.00
IUUC-Opr-070686 Ochotona princeps 88.84 0.00e+00 809.00
IUUC-Ont-072398 Oreochromis niloticus 84.75 0.00e+00 1588.00
IUUC-Oan-073194 Ornithorhynchus anatinus 94.86 0.00e+00 1732.00
IUUC-Ocu-074397 Oryctolagus cuniculus 85.89 0.00e+00 1567.00
IUUC-Ola-086777 Oryzias latipes 80.72 0.00e+00 1563.00
IUUC-Oga-088684 Otolemur garnettii 98.68 0.00e+00 1875.00
IUUC-Oar-089428 Ovis aries 98.44 0.00e+00 1845.00
IUUC-Ptr-090529 Pan troglodytes 98.24 0.00e+00 1873.00
IUUC-Pan-091702 Papio anubis 98.35 0.00e+00 1873.00
IUUC-Psi-093969 Pelodiscus sinensis 90.86 0.00e+00 1703.00
IUUC-Pfo-097364 Poecilia formosa 86.07 0.00e+00 1608.00
IUUC-Pab-098574 Pongo abelii 98.35 0.00e+00 1875.00
IUUC-Pca-100525 Procavia capensis 86.31 1.00e-177 617.00
IUUC-Pva-102365 Pteropus vampyrus 87.46 0.00e+00 1613.00
IUUC-Rno-105153 Rattus norvegicus 96.37 0.00e+00 1844.00
IUUC-Sha-107319 Sarcophilus harrisii 93.21 0.00e+00 1813.00
IUUC-Sar-113449 Sorex araneus 82.64 0.00e+00 627.00
IUUC-Ssc-115865 Sus scrofa 98.90 0.00e+00 1883.00
IUUC-Tgu-117225 Taeniopygia guttata 90.98 0.00e+00 1772.00
IUUC-Tru-118026 Takifugu rubripes 82.38 0.00e+00 1566.00
IUUC-Tsy-119407 Tarsius syrichta 85.48 0.00e+00 1575.00
IUUC-Tni-120234 Tetraodon nigroviridis 83.97 0.00e+00 1271.00
IUUC-Tbe-127708 Tupaia belangeri 88.66 0.00e+00 882.00
IUUC-Ttr-128667 Tursiops truncatus 98.68 0.00e+00 1880.00
IUUC-Vpa-130200 Vicugna pacos 98.75 0.00e+00 1821.00
IUUC-Xtr-132176 Xenopus tropicalis 87.18 0.00e+00 1697.00
Created Date 25-Jun-2017

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