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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063657
UUCD1 version UUC-MuM-00384
Ensembl Protein ID ENSMUSP00000039206.6
UniProt Accession Q3U0D9; F6VQI5; F7ALT5; Q5DTY7; Q8BXY2; Q8R160; Q8R3G4; HACE1_MOUSE
Genbank Protein ID BAC31390.1; BAE33915.1; AAH25227.1; AAH25474.1; AAI20696.1; AAI20698.1; BAD90440.1
Protein Name E3 ubiquitin-protein ligase HACE1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1
Genbank Nucleotide ID AK042879; AK156958; AC135669; BC025474; BC120695; BC120697; AK220383
Gene Name Hace1; Kiaa1320
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000038822.15 ENSMUST00000037044.12 ENSMUSP00000039206.6
ENSMUSG00000038822.15 ENSMUST00000131568.1 ENSMUSP00000121196.1
ENSMUSG00000038822.15 ENSMUST00000150511.7 ENSMUSP00000117985.1
ENSMUSG00000038822.15 ENSMUST00000131406.1 ENSMUSP00000118554.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDHINT
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.00e-118 396.8 576 905
Active Site
Position(s) Description Evidence
876 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 576  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 661
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 662  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 747
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e++++eer  +LqFvT
   Q: 748  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVT 836
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 837  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 905
           ******************8888888868888********************************986555 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (By similarity). May also act as a transcription regulator via its interaction with RARB.
 E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (By similarity). May also act as a transcription regulator via its interaction with RARB.
Protein Sequence
(Fasta)
MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063657|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCCCAGGA GGGAAGCGGG GCCGCGGCAG GAAAGGCGCG AGCGAGCGGA GGCGGCGGCT 60
GGTGCCCACC CCAGCGCGGT CTGGTTGGCA GCCGTCGGTG CGGCGGACTG ACTCGGCTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063657|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
Pfam

PF12796--Ank_2
PF00632--HECT
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00119--HECTc
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0032580--C:Golgi cisterna membrane
GO:0000139--C:Golgi membrane
GO:0017137--F:Rab GTPase binding
GO:0048365--F:Rac GTPase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007049--P:cell cycle
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:209462
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001490 Ailuropoda melanoleuca 96.38 0.00e+00 1837.00
IUUC-Apl-003400 Anas platyrhynchos 87.40 0.00e+00 1144.00
IUUC-Aca-005375 Anolis carolinensis 90.88 0.00e+00 1730.00
IUUC-Ame-011847 Astyanax mexicanus 84.96 0.00e+00 1644.00
IUUC-Bta-012831 Bos taurus 96.29 0.00e+00 1800.00
IUUC-Cja-019160 Callithrix jacchus 97.14 0.00e+00 1852.00
IUUC-Cfa-020346 Canis familiaris 96.59 0.00e+00 1845.00
IUUC-Cpo-021766 Cavia porcellus 96.26 0.00e+00 1842.00
IUUC-Csa-023768 Chlorocebus sabaeus 97.03 0.00e+00 1851.00
IUUC-Cho-024688 Choloepus hoffmanni 92.03 0.00e+00 1154.00
IUUC-Cin-025417 Ciona intestinalis 43.57 0.00e+00 701.00
IUUC-Csv-025993 Ciona savignyi 43.80 0.00e+00 753.00
IUUC-Dre-027819 Danio rerio 85.31 0.00e+00 1629.00
IUUC-Dno-029027 Dasypus novemcinctus 95.74 0.00e+00 1820.00
IUUC-Dor-030327 Dipodomys ordii 88.90 0.00e+00 1614.00
IUUC-Ete-032966 Echinops telfairi 89.01 0.00e+00 1678.00
IUUC-Eca-034339 Equus caballus 96.81 0.00e+00 1847.00
IUUC-Eeu-034544 Erinaceus europaeus 68.01 0.00e+00 672.00
IUUC-Fca-035617 Felis catus 96.14 0.00e+00 1309.00
IUUC-Fal-036687 Ficedula albicollis 90.02 0.00e+00 1751.00
IUUC-Gmo-039508 Gadus morhua 87.93 0.00e+00 830.00
IUUC-Gga-040845 Gallus gallus 90.55 0.00e+00 1770.00
IUUC-Gac-041894 Gasterosteus aculeatus 84.18 0.00e+00 1578.00
IUUC-Ggo-044465 Gorilla gorilla 93.31 0.00e+00 1772.00
IUUC-Hsa-045731 Homo sapiens 97.14 0.00e+00 1853.00
IUUC-Itr-048716 Ictidomys tridecemlineatus 96.92 0.00e+00 1847.00
IUUC-Lch-050436 Latimeria chalumnae 88.77 0.00e+00 1689.00
IUUC-Loc-052287 Lepisosteus oculatus 85.07 0.00e+00 1669.00
IUUC-Laf-053846 Loxodonta africana 96.81 0.00e+00 1845.00
IUUC-Mcc-055845 Macaca mulatta 97.14 0.00e+00 1853.00
IUUC-Meu-056060 Macropus eugenii 96.54 0.00e+00 700.00
IUUC-Mga-059935 Meleagris gallopavo 92.89 0.00e+00 1746.00
IUUC-Mmr-060960 Microcebus murinus 97.25 0.00e+00 1858.00
IUUC-Mdo-061851 Monodelphis domestica 91.72 0.00e+00 1797.00
IUUC-Mpu-066161 Mustela putorius furo 98.74 0.00e+00 828.00
IUUC-Mlu-067354 Myotis lucifugus 94.60 0.00e+00 1764.00
IUUC-Nle-069112 Nomascus leucogenys 97.25 0.00e+00 1857.00
IUUC-Opr-070686 Ochotona princeps 88.84 0.00e+00 812.00
IUUC-Ont-072398 Oreochromis niloticus 84.31 0.00e+00 1579.00
IUUC-Oan-073194 Ornithorhynchus anatinus 94.52 0.00e+00 1727.00
IUUC-Ocu-074397 Oryctolagus cuniculus 85.56 0.00e+00 1570.00
IUUC-Ola-086777 Oryzias latipes 80.65 0.00e+00 1567.00
IUUC-Oga-088684 Otolemur garnettii 97.25 0.00e+00 1857.00
IUUC-Oar-089428 Ovis aries 95.87 0.00e+00 1801.00
IUUC-Ptr-090529 Pan troglodytes 97.03 0.00e+00 1852.00
IUUC-Pan-091702 Papio anubis 97.03 0.00e+00 1852.00
IUUC-Psi-093969 Pelodiscus sinensis 90.53 0.00e+00 1705.00
IUUC-Pfo-097364 Poecilia formosa 85.42 0.00e+00 1607.00
IUUC-Pab-098574 Pongo abelii 97.14 0.00e+00 1853.00
IUUC-Pca-100525 Procavia capensis 86.03 3.00e-178 618.00
IUUC-Pva-102365 Pteropus vampyrus 85.15 0.00e+00 1575.00
IUUC-Rno-105153 Rattus norvegicus 98.35 0.00e+00 1873.00
IUUC-Sha-107319 Sarcophilus harrisii 91.83 0.00e+00 1795.00
IUUC-Sar-113449 Sorex araneus 79.34 2.00e-173 603.00
IUUC-Ssc-115865 Sus scrofa 96.59 0.00e+00 1847.00
IUUC-Tgu-117225 Taeniopygia guttata 90.13 0.00e+00 1762.00
IUUC-Tru-118026 Takifugu rubripes 82.27 0.00e+00 1566.00
IUUC-Tsy-119407 Tarsius syrichta 84.05 0.00e+00 1554.00
IUUC-Tni-120234 Tetraodon nigroviridis 83.31 0.00e+00 1264.00
IUUC-Tur-126774 Triticum urartu 29.17 6.00e-46 179.00
IUUC-Tbe-127708 Tupaia belangeri 85.77 0.00e+00 858.00
IUUC-Ttr-128667 Tursiops truncatus 96.48 0.00e+00 1846.00
IUUC-Vpa-130200 Vicugna pacos 96.38 0.00e+00 1783.00
IUUC-Xtr-132176 Xenopus tropicalis 87.29 0.00e+00 1700.00
Created Date 25-Jun-2017

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