iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073194

UUCD1 version

UUC-OrA-00150

Ensembl Protein ID

ENSOANP00000016345.2

UniProt Accession

F6TDU1; F6TDU1_ORNAN

Protein Name

Uncharacterized protein

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000010300.2	ENSOANT00000016348.2	ENSOANP00000016345.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-119	398.4	542	871

Active Site

Position(s)	Description	Evidence
842	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 542  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 627
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg ++s++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG++i Vt++Nk eYv+lv+e+
   Q: 628  FTRSFYKHILGIPVSYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQDNKAEYVQLVTEL 713
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G +eidv+d+ k+t+y++gy++++p+iqwFwev+e++++eer  +LqFvT
   Q: 714  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGLPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVT 802
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 803  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 871
           ******************8888888868888********************************986555 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MPMVMADQHR SVSELLSNSK FDVNYAFGRV KRSLLHIAAN CGSVECLVLL LKKGANPNYQ 60
DISGCTPLHL AARNGQKKCM SKLLEYSADV NICNNEGLTA IHWLAVNGRT ELLHDLVQHV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCCAATGTG TCGTATTAAA ATCCTTTTCT AATTTCCTAA ACAGATAACG AAACTGCTGT 60
CTACACACTA ATGCCAATGG TAATGGCGGA TCAGCACAGG TAAGTGCATA GCTCATGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

KEGG

oaa:100074429

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	94.65	0.00e+00	1729.00
IUUC-Apl-003400	Anas platyrhynchos	86.93	0.00e+00	1140.00
IUUC-Aca-005375	Anolis carolinensis	90.88	0.00e+00	1665.00
IUUC-Ame-011847	Astyanax mexicanus	84.77	0.00e+00	1585.00
IUUC-Bta-012831	Bos taurus	94.98	0.00e+00	1734.00
IUUC-Cja-019160	Callithrix jacchus	95.78	0.00e+00	1748.00
IUUC-Cfa-020346	Canis familiaris	94.86	0.00e+00	1732.00
IUUC-Cpo-021766	Cavia porcellus	94.41	0.00e+00	1728.00
IUUC-Csa-023768	Chlorocebus sabaeus	95.55	0.00e+00	1748.00
IUUC-Cho-024688	Choloepus hoffmanni	90.37	0.00e+00	1133.00
IUUC-Cin-025417	Ciona intestinalis	50.64	1.00e-138	486.00
IUUC-Csv-025993	Ciona savignyi	43.69	0.00e+00	728.00
IUUC-Dre-027819	Danio rerio	86.27	0.00e+00	1587.00
IUUC-Dno-029027	Dasypus novemcinctus	94.67	0.00e+00	1737.00
IUUC-Dor-030327	Dipodomys ordii	87.56	0.00e+00	1558.00
IUUC-Ete-032966	Echinops telfairi	87.90	0.00e+00	1597.00
IUUC-Eca-034339	Equus caballus	95.21	0.00e+00	1740.00
IUUC-Eeu-034544	Erinaceus europaeus	64.42	4.00e-167	581.00
IUUC-Fca-035617	Felis catus	93.84	0.00e+00	1270.00
IUUC-Fal-036687	Ficedula albicollis	90.31	0.00e+00	1691.00
IUUC-Gmo-039508	Gadus morhua	88.15	0.00e+00	833.00
IUUC-Gga-040845	Gallus gallus	90.42	0.00e+00	1703.00
IUUC-Gac-041894	Gasterosteus aculeatus	84.94	0.00e+00	1553.00
IUUC-Ggo-044465	Gorilla gorilla	91.81	0.00e+00	1671.00
IUUC-Hsa-045731	Homo sapiens	95.66	0.00e+00	1751.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	95.54	0.00e+00	1747.00
IUUC-Lch-050436	Latimeria chalumnae	89.10	0.00e+00	1628.00
IUUC-Loc-052287	Lepisosteus oculatus	84.99	0.00e+00	1603.00
IUUC-Laf-053846	Loxodonta africana	95.43	0.00e+00	1750.00
IUUC-Mcc-055845	Macaca mulatta	95.66	0.00e+00	1750.00
IUUC-Meu-056060	Macropus eugenii	97.12	0.00e+00	701.00
IUUC-Mga-059935	Meleagris gallopavo	93.49	0.00e+00	1711.00
IUUC-Mmr-060960	Microcebus murinus	95.43	0.00e+00	1745.00
IUUC-Mdo-061851	Monodelphis domestica	91.74	0.00e+00	1729.00
IUUC-Mmu-063657	Mus musculus	94.52	0.00e+00	1727.00
IUUC-Mpu-066161	Mustela putorius furo	97.74	0.00e+00	821.00
IUUC-Mlu-067354	Myotis lucifugus	94.75	0.00e+00	1706.00
IUUC-Nle-069112	Nomascus leucogenys	95.55	0.00e+00	1748.00
IUUC-Opr-070686	Ochotona princeps	87.93	0.00e+00	803.00
IUUC-Ont-072398	Oreochromis niloticus	84.77	0.00e+00	1554.00
IUUC-Ocu-074397	Oryctolagus cuniculus	84.45	0.00e+00	1485.00
IUUC-Ola-086777	Oryzias latipes	80.44	0.00e+00	1511.00
IUUC-Oga-088684	Otolemur garnettii	95.32	0.00e+00	1739.00
IUUC-Oar-089428	Ovis aries	94.21	0.00e+00	1692.00
IUUC-Ptr-090529	Pan troglodytes	95.55	0.00e+00	1749.00
IUUC-Pan-091702	Papio anubis	95.55	0.00e+00	1748.00
IUUC-Psi-093969	Pelodiscus sinensis	90.09	0.00e+00	1693.00
IUUC-Pfo-097364	Poecilia formosa	86.27	0.00e+00	1580.00
IUUC-Pab-098574	Pongo abelii	95.66	0.00e+00	1751.00
IUUC-Pca-100525	Procavia capensis	68.65	1.00e-165	576.00
IUUC-Pva-102365	Pteropus vampyrus	83.22	0.00e+00	1472.00
IUUC-Rno-105153	Rattus norvegicus	94.29	0.00e+00	1728.00
IUUC-Sha-107319	Sarcophilus harrisii	91.96	0.00e+00	1729.00
IUUC-Stu-112894	Solanum tuberosum	35.33	1.00e-54	207.00
IUUC-Sar-113449	Sorex araneus	76.37	1.00e-163	570.00
IUUC-Ssc-115865	Sus scrofa	94.75	0.00e+00	1732.00
IUUC-Tgu-117225	Taeniopygia guttata	90.20	0.00e+00	1703.00
IUUC-Tru-118026	Takifugu rubripes	82.30	0.00e+00	1533.00
IUUC-Tsy-119407	Tarsius syrichta	82.08	0.00e+00	1448.00
IUUC-Tni-120234	Tetraodon nigroviridis	83.57	0.00e+00	1228.00
IUUC-Tur-126774	Triticum urartu	29.17	5.00e-46	178.00
IUUC-Tbe-127708	Tupaia belangeri	83.95	0.00e+00	826.00
IUUC-Ttr-128667	Tursiops truncatus	94.52	0.00e+00	1729.00
IUUC-Vpa-130200	Vicugna pacos	94.75	0.00e+00	1727.00
IUUC-Xtr-132176	Xenopus tropicalis	86.59	0.00e+00	1628.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence