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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064074
UUCD1 version UUC-MuM-01158
Ensembl Protein ID ENSMUSP00000057282.7
UniProt Accession Q8R554; OTU7A_MOUSE
Genbank Protein ID CAD23048.1
Protein Name OTU domain-containing protein 7A; Zinc finger protein Cezanne 2
Genbank Nucleotide ID AJ430384
Gene Name Otud7a; Cezanne2; Otud7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000033510.14 ENSMUST00000058476.13 ENSMUSP00000057282.7
ENSMUSG00000033510.14 ENSMUST00000177534.1 ENSMUSP00000135559.1
ENSMUSG00000033510.14 ENSMUST00000177511.1 ENSMUSP00000134821.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/OTU 1.40e-40 140.0 202 377
UBD/ZnF/ZnF_A20 2.50e-15 57.2 885 919
Active Site
Position(s) Description Evidence
209 N/A {ECO:0000250}
212 Nucleophile ECO:0000250}
370 Proton acceptor ECO:0000250}
Domain Profile

   DUB/OTU
   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek....edekefcqklvepe.....ak.g.. 77
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al++++r+ +++++ k+++++++++++k    e+e++++ kl+++e     +k g  
   Q: 202  LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYTMMRTGAEREALKRRWRWQQTQQNKeeewEREWTELLKLASSEprthfSKnGsg 290
           6899********************************************************999999************88777443377 PP
   S: 78   ................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
                           ee+h+f+La+iL+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++aLv++
   Q: 291  tgggvdnsedpvyeslEEFHVFVLAHILRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPPNRcHCSPLVLAYDQAHFSALVSM 377
           889*********************************************************************************986 PP
   

   UBD/ZnF/ZnF_A20
   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrrr 35
           p++++C++ +C+fYG++et+++CS+Cyreelrrrr
   Q: 885  PAQRRCQReNCAFYGRAETEHFCSYCYREELRRRR 919
           99*******************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.
 Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MVSSLLPNPP SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE GKNWDLTAAL 60
SDYEQLRQVH TANLPHVFNE GRCAKQAERE LPQPGHKVER PCLQRQDDIA QAEKRLSRGI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064074|DUB,OTU;UBD,ZnF_A20|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCGGCGCAG CCAGGAAGGC GGGGGAGGAG AGGCCCGGGC GCCGCGCGGC AGCTGGGGAG 60
GGGGCCGCGG CTGGGCGCGA GCGGAACAGC TGATCTGGTT TTCCCGAAGC CAGGGAAGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064074|DUB,OTU;UBD,ZnF_A20|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20
PROSITE

PS50802--OTU
PS51036--ZF_A20
Pfam

PF02338--OTU
PF01754--zf-A20
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
KEGG mmu:170711
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001551 Ailuropoda melanoleuca 95.73 0.00e+00 1007.00
IUUC-Apl-003825 Anas platyrhynchos 71.22 0.00e+00 1146.00
IUUC-Aca-004392 Anolis carolinensis 75.43 0.00e+00 1150.00
IUUC-Ame-011052 Astyanax mexicanus 69.84 0.00e+00 1077.00
IUUC-Bta-013296 Bos taurus 88.94 0.00e+00 1229.00
IUUC-Cja-019141 Callithrix jacchus 92.88 0.00e+00 1049.00
IUUC-Cfa-020447 Canis familiaris 95.17 0.00e+00 1096.00
IUUC-Cpo-022059 Cavia porcellus 93.42 0.00e+00 940.00
IUUC-Csa-023263 Chlorocebus sabaeus 96.04 0.00e+00 1094.00
IUUC-Cho-024611 Choloepus hoffmanni 83.57 3.00e-159 555.00
IUUC-Dre-028617 Danio rerio 68.63 0.00e+00 1081.00
IUUC-Dno-029121 Dasypus novemcinctus 89.23 0.00e+00 1013.00
IUUC-Ete-033068 Echinops telfairi 73.03 0.00e+00 1007.00
IUUC-Eca-034413 Equus caballus 95.18 0.00e+00 1043.00
IUUC-Fca-036487 Felis catus 90.09 0.00e+00 967.00
IUUC-Fal-037145 Ficedula albicollis 77.56 0.00e+00 1177.00
IUUC-Gmo-038786 Gadus morhua 71.98 0.00e+00 855.00
IUUC-Gga-040512 Gallus gallus 76.85 0.00e+00 1185.00
IUUC-Gac-041599 Gasterosteus aculeatus 69.47 0.00e+00 1047.00
IUUC-Ggo-044819 Gorilla gorilla 89.91 0.00e+00 1253.00
IUUC-Hsa-046781 Homo sapiens 90.56 0.00e+00 1367.00
IUUC-Itr-047999 Ictidomys tridecemlineatus 86.74 0.00e+00 751.00
IUUC-Lch-050666 Latimeria chalumnae 72.94 0.00e+00 1115.00
IUUC-Loc-052841 Lepisosteus oculatus 69.97 0.00e+00 1112.00
IUUC-Laf-053437 Loxodonta africana 89.78 0.00e+00 1084.00
IUUC-Mcc-055353 Macaca mulatta 90.46 0.00e+00 1360.00
IUUC-Mga-059741 Meleagris gallopavo 73.09 0.00e+00 1159.00
IUUC-Mmr-061437 Microcebus murinus 97.20 0.00e+00 1163.00
IUUC-Mdo-061907 Monodelphis domestica 77.09 0.00e+00 1214.00
IUUC-Mpu-066004 Mustela putorius furo 93.03 0.00e+00 985.00
IUUC-Nle-069182 Nomascus leucogenys 94.18 0.00e+00 1138.00
IUUC-Opr-070701 Ochotona princeps 86.16 0.00e+00 890.00
IUUC-Ont-072431 Oreochromis niloticus 86.72 0.00e+00 847.00
IUUC-Oan-073235 Ornithorhynchus anatinus 83.33 0.00e+00 924.00
IUUC-Ocu-073935 Oryctolagus cuniculus 94.45 0.00e+00 1031.00
IUUC-Ola-087026 Oryzias latipes 66.95 0.00e+00 1060.00
IUUC-Oga-088249 Otolemur garnettii 93.76 0.00e+00 1102.00
IUUC-Oar-089476 Ovis aries 88.89 0.00e+00 1334.00
IUUC-Ptr-090548 Pan troglodytes 95.62 0.00e+00 1001.00
IUUC-Pan-092616 Papio anubis 88.59 0.00e+00 1278.00
IUUC-Psi-093126 Pelodiscus sinensis 76.61 0.00e+00 1169.00
IUUC-Pfo-096785 Poecilia formosa 66.42 0.00e+00 1040.00
IUUC-Pab-098336 Pongo abelii 90.65 0.00e+00 1199.00
IUUC-Pca-100206 Procavia capensis 80.80 0.00e+00 781.00
IUUC-Rno-105483 Rattus norvegicus 93.15 0.00e+00 1034.00
IUUC-Sha-106617 Sarcophilus harrisii 85.41 0.00e+00 897.00
IUUC-Ssc-115415 Sus scrofa 92.41 0.00e+00 1005.00
IUUC-Tgu-117218 Taeniopygia guttata 85.97 0.00e+00 1035.00
IUUC-Tru-118720 Takifugu rubripes 87.77 0.00e+00 835.00
IUUC-Tni-120795 Tetraodon nigroviridis 78.51 0.00e+00 910.00
IUUC-Xtr-132158 Xenopus tropicalis 69.14 0.00e+00 1157.00
IUUC-Xma-133941 Xiphophorus maculatus 79.82 0.00e+00 919.00
Created Date 25-Jun-2017

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